Results 131 to 140 of about 39,725 (289)

N‐methylation of histidine to tune tautomeric preferences in histidine‐heme coordination and enzyme‐mimetic catalysis

Smart Molecules
Enzymes with active sites involving histidine selectively utilize either the δ‐ or ε‐nitrogen atom (Nδ or Nε) of the histidine imidazole for catalysis.
Ruikai Du, Yunbo Lv, Haifeng Wu, Baoli Zhang, Yuanxi Liu, Shichao Xu, Shan Li, Zhen‐Gang Wang   +7 more
doaj   +1 more source

Engineering a Hybrid Heme Pathway for Hemoprotein‐Based Dye‐Decolorizing Peroxidase in Escherichia coli

Food Bioengineering, Volume 5, Issue 2, Page 209-219, June 2026.
In this study, the heme content and enzymatic activity of the RhDypB mutant strain RhDypB‐R80 were enhanced through optimized heme uptake and pathway integration. This engineered host presents a promising platform for hemoprotein engineering and holds potential for applications in controlling mycotoxin contamination in food products.
Yue Sun, Jin‐Ping Chen, Nan‐Kai Wang, Chang Su, Heng Li, Jin‐Song Gong, Zheng‐Hong Xu, Jin‐Song Shi   +7 more
wiley   +1 more source

DNA-enhanced peroxidase activity of a DNA aptamer-hemin complex

, 1998
Background: In vitro selection (SELEX) previously identified short single-stranded DNAs that specifically bound N-methylmesoporphyrin IX (NMM), a stable transition-state analogue for porphyrin-metallation reactions.
Travascio, Paola, Li, Yingfu, Sen, Dipankar   +2 more
core   +1 more source

Hemin enhances the 5-aminolevulinic acid-photodynamic therapy effect through the changes of cellular iron homeostasis

Photodiagnosis and Photodynamic Therapy
Background: Photodynamic therapy (PDT) has been utilized as a promising alternative cancer treatment due to its minimum invasiveness over the years. Exogenous 5-aminolevulinic acid (ALA) triggers protoporphyrin IX (PpIX) accumulation, which happens in ...
Anantya Pustimbara, Chenhan Li, Shun-ichiro Ogura   +2 more
doaj   +1 more source

Mechanochemical synthesis of hemin±imidazole complexes [PDF]

, 2013
Solid state reactions of hemin and imidazole were performed by milling the crystalline materials in an agate mortar. The process was monitored by i.r., x.r.d. and MoÈ ssbauer spectroscopies.
FERNANDEZ BERTRAN, JOSE, REGUERA, EDILSO, YEE-MADEIRA, HERNANI, PENEQUE, ARMANDO   +3 more
core  

Hemin-induced transient senescence via DNA damage response: a neuroprotective mechanism against ferroptosis in intracerebral hemorrhage

Communications Biology
Intracerebral hemorrhage (ICH) poses acute fatality and long-term neurological risks, in part due to hemin and iron accumulation from hemoglobin breakdown.
Vikas H. Malojirao, Velmarini Vasquez, Manohar Kodavati, Joy Mitra, Vincent Provasek, Anh Tran Tram Voh, Anton V. Liopo, Paul J. Derry, Andrei M. Mikheev, Robert C. Rostomily, Philip J. Horner, James M. Tour, Gavin W. Britz, Thomas A. Kent, Muralidhar L. Hegde   +14 more
doaj   +1 more source

Acetate‐Linked Energy Metabolism as a Determinant of Early Haemophilus influenzae Infection Fitness

MicrobiologyOpen, Volume 15, Issue 3, June 2026.
The Pta–AckA pathway is critical for Haemophilus influenzae energy generation, metabolic homeostasis, stress resistance, and intracellular colonization, highlighting its potential as a target for management of H. influenzae infections.
Marufa Nasreen, Jennifer Hosmer, Saurab Kishore Munshi, Riya Joshi, Ayaho Yamamoto, Horst J. Schirra, Peter Sly, Alastair G. McEwan, Ulrike Kappler   +8 more
wiley   +1 more source

Resolving the effects of albumin glycation using the quartz crystal microbalance

MATEC Web of Conferences, 2013
Both lysine and arginine residues are particularly important at receptor sites for binding anionic ligands. These receptor sites may become compromised via non-enzymatic glycation.
Heller G.T., Zwang T.J., Sazinsky M.H., Johal M.S.   +3 more
doaj   +1 more source

Near Infrared Responsive Injectable Hydrogel with Bioactive Glass and Copper Nanostructures for Photothermal Antibacterial and Periodontitis Treatment

Nano Select, Volume 7, Issue 6, June 2026.
An injectable hydrogel incorporating copper–tannic acid (CuT) and bioactive glass was developed for the treatment of periodontitis. The hydrogel exhibited excellent injectability, biocompatibility, and both inherent and photothermal antibacterial activity.
Satar Yousefiasl, Zahra Ajali, Faezeh Almasi, Laleh Salarilak, Masoumeh Mohamadhoseini, Nushin Khoubi Nobari, Kiana Nazari Nasi, Maryam Pourhajibagher, Mojgan Alaeddini, Farnaz Eslami, Zahra Mohamadnia, Aziz Maleki   +11 more
wiley   +1 more source

Structural Analysis and Inhibitor Modeling of Bacterioferritin From Brucella abortus

Proteins: Structure, Function, and Bioinformatics, Volume 94, Issue 6, Page 1170-1181, June 2026.
ABSTRACT Iron homeostasis in various pathogenic bacteria is regulated by bacterioferritins (Bfr) which function to store Fe3+ and release Fe2+ as needed for metabolic processes. The Bfr structure consists of 18 kDa subunits in which dimer pairs bind a heme molecule and are assembled into a highly symmetrical 24‐meric spherical structure with an ...
Lijun Liu, Elizabeth K. Harmon, Justin K. Craig, Huili Yao, Kevin P. Battaile, David K. Johnson, Sandhya Subramanian, Wesley C. Van Voorhis, Mario Rivera, Scott Lovell   +9 more
wiley   +1 more source