Results 31 to 40 of about 22,100 (162)

Hemin and iron increase synthesis and trigger export of xanthine oxidoreductase from hepatocytes to the circulation

Redox Biology, 2023
We recently reported a previously unknown salutary role for xanthine oxidoreductase (XOR) in intravascular heme overload whereby hepatocellular export of XOR to the circulation was identified as a seminal step in affording protection.
Evan R. DeVallance, Heidi M. Schmidt, Madison Seman, Sara E. Lewis, Katherine C. Wood, Schuyler D. Vickers, Scott A. Hahn, Murugesan Velayutham, Emily A. Hileman, Dario A. Vitturi, Roberta Leonardi, Adam C. Straub, Eric E. Kelley   +12 more
doaj   +1 more source

Inhibitory Effect of Hemin-Polymer System Against Escherichia coli and Staphylococcus aureus

Антибиотики и Химиотерапия
Background. Wound infections of bacterial etiology are a socially significant problem. The lack of rational antibiotic therapy can lead to an increase in the emergence of resistant strains of microorganisms.
O. A. Gruznova, D. V. Gruznov, N. I. Popov, G. Sh. Shcherbakova, E. N. Shuteeva, A. V. Lobanov, P. M. Tyubaeva, I. A. Varyan, A. A. Olkhov   +8 more
doaj   +1 more source

Proteomic analysis of the effect of hemin in breast cancer

Scientific Reports, 2023
Heme, an iron-containing prosthetic group found in many proteins, carries out diverse biological functions such as electron transfer, oxygen storage and enzymatic reactions.
G. P. Coló, K. Schweitzer, G. M. Oresti, E. G. Alonso, L. Fernández Chávez, M. Mascaró, G. Giorgi, A. C. Curino, M. M. Facchinetti   +8 more
doaj   +1 more source

Binding and accumulation of hemin in Porphyromonas gingivalis are induced by hemin [PDF]

Infection and Immunity, 1994
Although hemin is an essential nutrient for the black-pigmented oral bacterium Porphyromonas gingivalis, the mechanisms involved in hemin binding and uptake are poorly defined. In this study, we have examined the binding of hemin and Congo red (CR) to P. gingivalis whole cells and have defined the conditions for maximal binding.
C A, Genco, B M, Odusanya, G, Brown
openaire   +2 more sources

Contribution of PGE2 EP1 receptor in hemin-induced neurotoxicity

Frontiers in Molecular Neuroscience, 2013
Although hemin-mediated neurotoxicity has been linked to the production of free radicals and glutamate excitotoxicity, the role of the prostaglandin E2 (PGE2)-EP1 receptor remains unclear.
Shekher eMohan, Alexander V. Glushakov, Alexander edeCurnou, Shuh eNarumiya, Sylvain eDoré   +4 more
doaj   +1 more source

Interactions of hemin, antimalarial drugs and hemin-antimalarial complexes with phospholipid monolayers [PDF]

Chemistry and Physics of Lipids, 1984
Hemin, antimalarial drugs and complexes formed between them, have demonstrable effects on biological membranes. Using the phospholipid monolayer model, we show that hemin intercalates into the membrane and increases its surface pressure, depending on the lipid composition and the initial surface pressure: negative surface charges and particularly ...
Ginsburg, H., Demel, R.A.
openaire   +3 more sources

Induction of Heme Oxygenase-1 Modifies the Systemic Immunity and Reduces Atherosclerotic Lesion Development in ApoE Deficient Mice

Frontiers in Pharmacology, 2022
Heme oxygenase-1 (HO-1) has been reported to protect against oxidation and inflammation in atherosclerosis. It remains unclear how the immune system participates in the cytoprotective function of HO-1 in the context of atherosclerosis.
Leyi Yao, Leyi Yao, Yali Hao, Guanmei Wen, Guanmei Wen, Qingzhong Xiao, Penglong Wu, Jinheng Wang, Jinbao Liu   +8 more
doaj   +1 more source

The Porphyromonas gingivalis ferric uptake regulator orthologue binds hemin and regulates hemin-responsive biofilm development.

PLoS ONE, 2014
Porphyromonas gingivalis is a Gram-negative pathogen associated with the biofilm-mediated disease chronic periodontitis. P. gingivalis biofilm formation is dependent on environmental heme for which P.
Catherine A Butler, Stuart G Dashper, Lianyi Zhang, Christine A Seers, Helen L Mitchell, Deanne V Catmull, Michelle D Glew, Jacqueline E Heath, Yan Tan, Hasnah S G Khan, Eric C Reynolds   +10 more
doaj   +1 more source

Improving the anthocyanin accumulation of hypocotyls in radish sprouts by hemin-induced NO

BMC Plant Biology, 2022
Background The health benefits of anthocyanins impel researchers and food producers to explorer new methods to increase anthocyanin contents in plant foods. Our previous studies revealed a positive role of nitric oxide (NO) in anthocyanin accumulation in
Nana Su, Ze Liu, Lu Wang, Yuanyuan Liu, Mengyang Niu, Xin Chen, Jin Cui   +6 more
doaj   +1 more source

Hemin regulates platelet clearance in hemolytic disease by binding to GPIbα

Platelets
Hemolysis is associated with thrombosis and vascular dysfunction, which are the pathological components of many diseases. Hemolytic products, including hemoglobin and hemin, activate platelets (PLT).
Man Zhao, Dongxin Peng, Yuxuan Li, Minwei He, Yulong Zhang, Qianqian Zhou, Sujing Sun, Ping Ma, Liping Lv, Xiaohui Wang, Linsheng Zhan   +10 more
doaj   +1 more source