Results 51 to 60 of about 39,725 (289)

Biological Oxidations and Nitrations Promoted by the Hemin–Aβ₁₆ Complex

Antioxidants, 2023
Both β-amyloid (Aβ) peptides and oxidative stress conditions play key roles in Alzheimer’s disease. Hemin contributes to the development of the disease as it possesses redox properties and its level increases in pathological conditions or traumatic brain
Silvia De Caro, Giulia De Soricellis, Simone Dell’Acqua, Enrico Monzani, Stefania Nicolis   +4 more
doaj   +1 more source

Release of hepatic xanthine oxidase (XO) to the circulation is protective in intravascular hemolytic crisis

Redox Biology, 2023
Xanthine oxidase (XO) catalyzes the catabolism of hypoxanthine to xanthine and xanthine to uric acid, generating oxidants as a byproduct. Importantly, XO activity is elevated in numerous hemolytic conditions including sickle cell disease (SCD); however ...
Heidi M. Schmidt, Evan R. DeVallance, Sara E. Lewis, Katherine C. Wood, Gowtham K. Annarapu, Mara Carreño, Scott A. Hahn, Madison Seman, Brooke A. Maxwell, Emily A. Hileman, Julia Z. Xu, Murugesan Velayutham, Werner J. Geldenhuys, Dario A. Vitturi, Sruti Shiva, Eric E. Kelley, Adam C. Straub   +16 more
doaj   +1 more source

Once-monthly hemin suppresses inflammatory and autoreactive CD4+ T cell responses to robustly ameliorate experimental rheumatoid arthritis

iScience, 2021
Summary: Rheumatoid arthritis (RA) is an inflammatory autoimmune disease that would permanently damage the affected joints. Unfortunately, a large proportion of RA patients fail to respond adequately to current treatments. Here, repurposing hemin and its
Bingzhi Sun, Gaojie Li, Ling Guo, Na Yin, Huan Huang, Xiaodong Wu, Runyue Huang, Min Feng   +7 more
doaj   +1 more source

Hemin-Bridged MOF Interface with Double Amplification of G‑Quadruplex Payload and DNAzyme Catalysis: Ultrasensitive Lasting Chemiluminescence MicroRNA Imaging

, 2020
Here, we report a double-amplified sensing platform for ultrasensitive chemiluminescence (CL) miRNA detection in real patients’ blood in which a hemin-bridged metal–organic framework (MOF) is employed as a functional interface to boost the payload and ...
Lin Shi, Lan Mi (813938), Tao Li (86810), Lan Mi, Tao Li, Yudie Sun (1823617), Lin Shi (65217), Yudie Sun   +7 more
core   +1 more source

Hemin uptake in Porphyromonas gingivalis: Omp26 is a hemin-binding surface protein [PDF]

Journal of Bacteriology, 1993
A 26-kDa outer membrane protein (Omp26) has been proposed to play a role in hemin acquisition by Porphyromonas gingivalis (T. E. Bramanti and S. C. Holt, J. Bacteriol. 174:5827-5839, 1992). We studied [55Fe]hemin uptake in P. gingivalis grown under conditions of hemin starvation (Omp26 expressed on the outer membrane surface) and hemin excess (Omp26 ...
T E, Bramanti, S C, Holt
openaire   +2 more sources

Hemin induces autophagy in a leukemic erythroblast cell line through the LRP1 receptor [PDF]

, 2019
Hemin is an erythropoietic inductor capable of inducing autophagy in erythroid-like cell lines. Low-density lipoprotein receptor-related protein 1 (LRP1) is a transmembrane receptor involved in a wide range of cellular processes, such as proliferation ...
Subirada Caldarone, Paula Virginia, Colombo, Maria Isabel, Chiabrando, Gustavo Alberto, Grosso, Rubén Adrián, Fader Kaiser, Claudio Marcelo, Sánchez Idiart, María Cecilia   +5 more
core   +1 more source

Hemin-graphene oxide-gold nanoflower-assisted enhanced electrochemiluminescence immunosensor for determination of prostate-specific antigen

, 2022
Hemin-graphene oxide-gold nanoflower-assisted enhanced electrochemiluminescence immunosensor for determination of prostate-specific ...
Hong Zhou (29614), Gengjun Liu (17257970), Xiaohan Guan (15998363), Binxiao Li (9022175), Na Kong (14681869), Haiyan Wang (25821)   +5 more
core  

Esterification of hemins with trimethyloxonium tetrafluoroborate [PDF]

Analytical Biochemistry, 1976
A procedure has been developed for the methylation of hemins using trimethyloxonium tetrafluoroborate. The method is rapid and selective for carboxyl groups, and it can be used to methylate polar and nonpolar hemins under neutral and basic conditions. Esterifications of protohemin IX, hematohemin.
Dean, Richard T., DeFilippi, Louis J., Hultquist, Donald E.   +2 more
openaire   +3 more sources

Hemin Prevents Increased Glycolysis in Macrophages upon Activation: Protection by Microbiota-Derived Metabolites of Polyphenols

, 2020
Meat consumption plays a critical role in the development of several types of cancer. Hemin, a metabolite of myoglobin produced after meat intake, has been demonstrated to be involved in the cancer initiation phase.
Avery, VM, Vicky M. Avery, Catalina Carrasco-Pozo, Tan, KN, Carrasco-Pozo, C, Kah Ni Tan   +5 more
core   +1 more source

Hemin availability induces coordinated DNA methylation and gene expression changes in Porphyromonas gingivalis

mSystems, 2023
Periodontal disease is a chronic inflammatory disease in which the oral pathogen Porphyromonas gingivalis plays an important role. Porphyromonas gingivalis expresses virulence determinants in response to higher hemin concentrations, but the underlying ...
Ricardo Costeira, Joseph Aduse-Opoku, Jon J. Vernon, Francisco Rodriguez-Algarra, Susan Joseph, Deirdre A. Devine, Philip D. Marsh, Vardhman Rakyan, Michael A. Curtis, Jordana T. Bell   +9 more
doaj   +1 more source