Results 81 to 90 of about 24,019 (190)

Interaction of antimalarial drugs with hemin

Bioscience Reports, 1983
Hemin (ferriprotoporphyrin IX) is shown to form complexes with the chloroquine class of antimalarial drugs. The Soret band of hemin becomes optically active upon the addition of chiral drugs. Results on the hemin-induced quenching of the fluorescence of chloroquine are consistent with the formation of a 2:1 hemin:drug complex with a formation constant ...
B, Panijpan, C, Mohan Rao, D, Balasubramanian   +2 more
openaire   +2 more sources

Ellagic Acid Enhances RSL3‐Induced Ferroptosis by Inhibiting the Nrf2/HO‐1 Signaling Pathway in Pancreatic Ductal Adenocarcinoma

The FASEB Journal, Volume 40, Issue 18, 30 September 2026.
Ellagic acid potentiates RSL3‐induced ferroptosis in PANC‐1 by suppressing the Nrf2/HO‐1 antioxidant defense axis via p38 MAPK activation and Keap1 upregulation. In PDAC cells, constitutive Nrf2/HO‐1 signaling establishes a robust antioxidant shield (GPX4, HO‐1) that limits lipid ROS accumulation and confers ferroptosis resistance.
Jianhua Bai, Yihe Dai, Chern Ein Oon, Pingping Hu, Jia Luo, Jiang Han, Liman Yang, Amirabas Bostani, Zhenhao Fei, Yun Jin   +9 more
wiley   +1 more source

Hemin enhances the 5-aminolevulinic acid-photodynamic therapy effect through the changes of cellular iron homeostasis

Photodiagnosis and Photodynamic Therapy
Background: Photodynamic therapy (PDT) has been utilized as a promising alternative cancer treatment due to its minimum invasiveness over the years. Exogenous 5-aminolevulinic acid (ALA) triggers protoporphyrin IX (PpIX) accumulation, which happens in ...
Anantya Pustimbara, Chenhan Li, Shun-ichiro Ogura   +2 more
doaj   +1 more source

Hemin-induced transient senescence via DNA damage response: a neuroprotective mechanism against ferroptosis in intracerebral hemorrhage

Communications Biology
Intracerebral hemorrhage (ICH) poses acute fatality and long-term neurological risks, in part due to hemin and iron accumulation from hemoglobin breakdown.
Vikas H. Malojirao, Velmarini Vasquez, Manohar Kodavati, Joy Mitra, Vincent Provasek, Anh Tran Tram Voh, Anton V. Liopo, Paul J. Derry, Andrei M. Mikheev, Robert C. Rostomily, Philip J. Horner, James M. Tour, Gavin W. Britz, Thomas A. Kent, Muralidhar L. Hegde   +14 more
doaj   +1 more source

Dual-Function Role of Phenolated Albumin in Hemin-Mediated Hydrogel Formation

Gels
Enzymatically crosslinked hydrogels are important in biomedical applications. However, conventional horseradish peroxidase (HRP)-based systems are expensive, unstable, and potentially immunogenic.
Shinji Sakai, Yuki Kitatani, Maasa Shiba, Thotage Asanka Vishwanath, Kelum Chamara Manoj Lakmal Elvitigala, Wildan Mubarok, Kousuke Moriyama   +6 more
doaj   +1 more source

Resolving the effects of albumin glycation using the quartz crystal microbalance

MATEC Web of Conferences, 2013
Both lysine and arginine residues are particularly important at receptor sites for binding anionic ligands. These receptor sites may become compromised via non-enzymatic glycation.
Heller G.T., Zwang T.J., Sazinsky M.H., Johal M.S.   +3 more
doaj   +1 more source

Exogenous Hemin Increases the Yield, Phenolic Compound Content, and Antioxidant Enzyme Activity of Dragon Fruit during the High-Temperature Period

Agronomy
Dragon fruits have abundant nutritional and antioxidant properties. High temperatures limit the growth and production of dragon fruits. Hemin can effectively alleviate abiotic stress in plants.
Minmin Sun, Aaqil Khan, Jiahui Wang, Linchong Ding, Xiaohui Yang, Jian Xiong, Zhiyuan Sun, Naijie Feng, Dianfeng Zheng   +8 more
doaj   +1 more source

Synthesis of a hemin-containing copolymer as a novel immunostimulator that induces IFN-gamma production

International Journal of Nanomedicine, 2018
Kazuaki Hoshi,1 Tomohiko Yamazaki,2 Chiaki Yoshikawa,3 Wakako Tsugawa,1 Kazunori Ikebukuro,1 Koji Sode1,4 1Department of Biotechnology and Life Science, Graduate School of Engineering, Tokyo University of Agriculture & Technology, Koganei, Tokyo ...
Hoshi K, Yamazaki T, Yoshikawa C, Tsugawa W, Ikebukuro K, Sode K   +5 more
doaj  

Notoginsenoside R1 Attenuates Oxidative Damage After Intracerebral Hemorrhage by Inhibiting LCN2 and Promoting HO-1 in Astrocytes. [PDF]

Brain Sci
Liu Q, Chen X, Wang B, Sun Y, Bian L.
europepmc   +1 more source

Regulatory mechanism of heme-regulated inhibitor through autophosphorylation-driven activation and heme-induced deactivation. [PDF]

J Biochem
Oka T, Yoshida H, Mizutani K, Obayashi E, Park SY, Iwasaki K.   +5 more
europepmc   +1 more source