Results 11 to 20 of about 582 (156)

Characteristics and Lethality of a Novel Recombinant  Dermonecrotic Venom Phospholipase D from  Hemiscorpius lepturus [PDF]

Toxins, 2017
Hemoscorpius lepturus is the most medically important scorpion in Iran. The clinical signs of H. lepturus envenomation are remarkably similar to those reported for brown spiders, including dermonecrosis, hematuria, renal failure and even death.
Elham Torabi, Mahdi Behdani, Mohammad Hosseininejad Chafi, Reza Moazzami, Jean‐Marc Sabatier, Vahid Khalaj, Delavar Shahbazzadeh, Kamran Pooshang Bagheri   +7 more
doaj   +7 more sources

Biochemical characterization and activity profiling of recombinant phospholipase A2 from Hemiscorpius lepturus expressed in E. coli with in vivo antibody response [PDF]

Scientific Reports
The structure and function of phospholipase A2 (PLA2) in scorpion venom are relatively unexplored, making further study crucial. This research aims to pave the way for a better understanding of scorpion venom, including the biochemical identification and
Moslem Najafi, Delavar Shahbazzadeh, Parichehreh Yaghmaie, Hasan Mirzahoseini   +3 more
doaj   +3 more sources

Correlation between coenzyme Q10 content and the nutrient sensors in AKI induced by Hemiscorpius lepturus envenomation [PDF]

BioImpacts, 2022
Introduction: Acute kidney injury (AKI) may have a negative effect on mitochondrial hemostasis and bioenergetics as well as coenzyme Q10 (CoQ10) content. PGC-1α, AMPK, sirtuin 1 (Sirt1), and Sirt3, as the key metabolic regulators under nutritional stress,
Rana Dizaji, Ali Sharafi, Jalal Pourahmad, Saba Vatanpour, Hossein Dinmohammadi, Hossein Vatanpour, Mir-Jamal Hosseini   +6 more
doaj   +4 more sources

Hemicalcin, a new toxin from the Iranian scorpion Hemiscorpius lepturus which is active on ryanodine-sensitive Ca2+ channels. [PDF]

Biochem J, 2007
Lien vers texte intégral : http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=17291197International audienceIn the present work, we purified and characterized a novel toxin named hemicalcin from the venom of the Iranian chactoid ...
Shahbazzadeh D, Srairi-Abid N, Feng W, Ram N, Borchani L, Ronjat M, Akbari A, Pessah IN, De Waard M, El Ayeb M.   +9 more
europepmc   +6 more sources

Molecules, Morphometrics and Modeling of the Medically Important Genus Hemiscorpius Peters, 1861 (Scorpiones: Hemiscorpiidae) in Iran Reveal New Species from Kerman [PDF]

Insects
Eight species of the medically important scorpion genus Hemiscorpius Peters, 1861 have been reported in Iran, three of which are responsible for most of the severe clinical cases of envenomation.
Hossein Dehghan, Esmail Amiri Ghanat Saman, Seyed Massoud Madjdzadeh, Masoumeh Amiri, Asma Moeinadini, Lorenzo Prendini, Hossein Barahoei   +6 more
doaj   +2 more sources

Presence probability of Hemiscorpius lepturus Peters, 1861 using maximum entropy approach in the western areas of Zagros Mountains, Iran [PDF]

Veterinary World, 2020
Aim: The purpose of this research was to use environmental variables for predicting the probability of Hemiscorpius lepturus existence in the provinces where situated in the west of the Zagros Mountains.
Ahmad Ali Hanafi-Bojd, Mona Sharififard, Elham Jahanifard, Shahrokh Navidpour, Babak Vazirianzadeh   +4 more
doaj   +2 more sources

Applying Ensemble Ecological Niche Modeling to Identify High Risk Areas for Scorpions' Sting. [PDF]

Ecol Evol
In this study, we used ecological niche models to map the distribution of eight of the most dangerous scorpion species to quantify sting risk across Iran. We identified the areas where people are most vulnerable to scorpion stings based on exposure to scorpions and limited accessibility to healthcare centers.
Kafash A, Bojd AAH, Pintor A, Grünig M, Yousefi M, Hassanpour G.   +5 more
europepmc   +2 more sources

In vivo pharmacological study on the effectiveness of available polyclonal antivenom against Hemiscorpius lepturus venom [PDF]

Journal of Venomous Animals and Toxins including Tropical Diseases, 2011
The available Razi Institute antivenom is still, empirically, used by intramuscular (IM) administration for the treatment of scorpion stings in humans by six medically dangerous species including Hemiscorpius lepturus (H. lepturus). The aim of this study
A Jalali, M H Pipelzadeh, R Seyedian, A H Rahmani, N Omidian   +4 more
doaj   +3 more sources

Discovery of broadly-neutralizing antibodies against brown recluse spider and Gadim scorpion sphingomyelinases using consensus toxins as antigens. [PDF]

Protein Sci
Abstract Broadly‐neutralizing monoclonal antibodies are becoming increasingly important tools for treating infectious diseases and animal envenomings. However, designing and developing broadly‐neutralizing antibodies can be cumbersome using traditional low‐throughput iterative protein engineering methods. Here, we present a new high‐throughput approach
Rivera-de-Torre E, Lampadariou S, Møiniche M, Bohn MF, Kazemi SM, Laustsen AH.   +5 more
europepmc   +2 more sources

ADAMTS-13 deficiency following Hemiscorpius lepturus scorpion sting

Saudi Journal of Kidney Diseases and Transplantation, 2011
Hemiscorpius lepturus is a lethal scorpion with potentially cytotoxic venom. Various degrees of local and systemic toxicity have been observed after its envenomation ranging from local erythema to disseminated intravascular coagulation, renal failure and
Ehsan Valavi, Mohammad Javad Alemzadeh Ansari, Sudabeh Hoseini   +2 more
doaj   +2 more sources