Results 81 to 90 of about 49,325 (314)
Genetics, Genetic Testing, and Management of Hemochromatosis: 15 Years Since Hepcidin.
Gastroenterology, 2015 The discovery of hepcidin in 2000 and the subsequent unprecedented explosion of research and discoveries in the iron field have dramatically changed our understanding of human disorders of iron metabolism.
A. Pietrangelo
semanticscholar +1 more source
Polysulfides From Inverse Vulcanization Used in Electronic Tongues for Heavy Metal Sensing
Journal of Applied Polymer Science, EarlyView.Schematic illustration of the polysulfide‐based e‐tongue system. ABSTRACT Polysulfides (PS) are versatile sulfur‐rich polymers synthesized via the inverse vulcanization of elemental sulfur, a simple one‐pot method that transforms an abundant, low‐cost residue into a functional material. In this work, we employed different PS structures as sensing units
Stella F. Valle +5 more
wiley +1 more source
The Myths and Realities of Hemochromatosis
Canadian Journal of Gastroenterology, 2007 Hemochromatosis is a common genetic condition and yet there are still a number of misperceptions surrounding the diagnosis and management of this condition. Hemochromatosis affects both men and women.
Melanie D Beaton, Paul C Adams
doaj +1 more source
Severe osteoporosis as atypical presentation of hereditary hemochromatosis
Clinical Case Reports, 2022 Besides important metabolic repercussions, iron overload is reported to be associated with deleterious effects on articulations and bones. We present the case of a male patient diagnosed with severe osteoporosis and vertebral fracture, in whom the ...
Georgiana Cristina Taujan +5 more
doaj +1 more source
Manganese Neurotoxicity and Familial Disorders of Manganese Transport
Annals of the Child Neurology Society, EarlyView.ABSTRACT Manganese is the 12th most common element in the Earth's crust and is an essential industrial component. Biologically, this metal plays an important role as a constituent of numerous enzymes. While manganese is required for normal biochemical and physiological processes, manganese excess can lead to significant toxicity, particularly to the ...
Sidney M. Gospe Jr.
wiley +1 more source
HFE-Related Hemochromatosis in a Chinese Patient: The First Reported Case
Frontiers in Genetics, 2020 HFE-related Hemochromatosis is the most common genetic iron overload disease in European populations, particularly of Nordic or Celtic ancestry.
Wei Zhang +28 more
doaj +1 more source
Inflammation can increase hepcidin in HFE‐hereditary hemochromatosis
Clinical Case Reports, 2021 We present a p.C282Y homozygous patient with high hepcidin levels and normal iron parameters during systemic inflammation. This suggests that in the absence of a proper functioning HFE, resulting in blockage of the BMP/SMAD pathway, the innate low ...
Wenke Moris +6 more
doaj +1 more source
Dietary Iron Overload and Hfe−/− Related Hemochromatosis Alter Hepatic Mitochondrial Function
Antioxidants, 2021 Iron is an essential co-factor for many cellular metabolic processes, and mitochondria are main sites of utilization. Iron accumulation promotes production of reactive oxygen species (ROS) via the catalytic activity of iron species.
Christine Fischer +11 more
doaj +1 more source
Rare autosomal dominant hereditary hemochromatosis associated with SLC40A1 gene: ferroportin disease or type 4 hereditary hemochromatosis? [PDF]
, 2019 Ferroportin (FPN1), encoded by the SLC40A1 gene, is the unique cellular iron exporter identified in mammals. FPN1 transfers iron from the intestine and macrophages into the bloodstream. This function is negatively regulated by hepcidin.
Faustino, Paula +7 more
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