Immunotherapeutic Potential of Mollusk Hemocyanins in Murine Model of Melanoma [PDF]
Marine DrugsThe development of antitumor drugs and therapy requires new approaches and molecules, and products of natural origin provide intriguing alternatives for antitumor research. Gastropodan hemocyanins-multimeric copper-containing glycoproteins have been used
Andrey Tchorbanov +2 more
exaly +5 more sources
De Novo Structural Determination of the Oligosaccharide Structure of Hemocyanins from Molluscs [PDF]
Biomolecules, 2020 A number of studies have shown that glycosylation of proteins plays diverse functions in the lives of organisms, has crucial biological and physiological roles in pathogen–host interactions, and is involved in a large number of biological events in the ...
Pavlina Dolashka +2 more
exaly +5 more sources
Assessment of the In Vitro and In Vivo Antitumor Activity of Hemocyanins from Helix aspersa, Helix lucorum, and Rapana venosa in a Graffi Myeloid Tumor Model [PDF]
Biomedicines, 2023 Hemocyanins are oxygen-transporting glycoproteins in the hemolymph of some invertebrate species that attracted scientific interest as potential anticancer agents.
Ani Georgieva +9 more
doaj +3 more sources
Hemocyanins from Helix and Rapana Snails Exhibit in Vitro Antitumor Effects in Human Colorectal Adenocarcinoma [PDF]
Biomedicines, 2020 Hemocyanins are oxygen-transporting glycoproteins in the hemolymph of arthropods and mollusks that attract scientific interest with their diverse biological activities and potential applications in pharmacy and medicine.
Ani Georgieva +9 more
doaj +3 more sources
Biophysical Characterization of Shrimp Hemocyanins: Stability and Emerging Biotechnological Applications [PDF]
BiomoleculesHemocyanins are oxygen-transporting proteins found in crustaceans and other arthropods, playing key roles in immune defense and metabolic regulation. Due to their stability and bioactive properties, Hcs have gained increasing interest in biotechnological
Lierge Ramos +8 more
doaj +3 more sources
Modified Hemocyanins from Rapana thomasiana and Helix aspersa Exhibit Strong Antitumor Activity in the B16F10 Mouse Melanoma Model [PDF]
Marine DrugsMelanoma is one of the most common tumors worldwide, and new approaches and antitumor drugs for therapy are being investigated. Among the promising biomolecules of natural origin for antitumor research are gastropodan hemocyanins—highly immunogenic ...
Emiliya Stoyanova +7 more
doaj +3 more sources
CryoEM structure and Alphafold molecular modelling of a novel molluscan hemocyanin. [PDF]
PLoS ONE, 2023 Hemocyanins are multimeric oxygen transport proteins present in the blood of arthropods and molluscs, containing up to 8 oxygen-binding functional units per monomer.
Gaia Pasqualetto +13 more
doaj +3 more sources
Conformational stability of hemocyanins regulates their lysosomal and proteasomal degradation, influencing their pro-inflammatory effects on mammalian antigen-presenting cells [PDF]
Frontiers in ImmunologyIntroductionMollusk hemocyanins are known for their immunomodulatory properties in mammals. Their applications include serving as carrier glycoproteins, functioning as protein-based adjuvants, and acting as non-specific immunostimulants in cancer vaccine
Michelle L. Salazar +12 more
doaj +2 more sources
Hemocyanins: Microscopic Giants with Unique Structural Features for Applications in Biomedicine [PDF]
VaccinesVaccine adjuvants play a crucial role in the field of vaccinology, yet they remain one of the least developed and poorly characterized components of modern biomedical research.
Michelle L. Salazar +6 more
doaj +2 more sources
Journal of Immunology Research, 2019 Mollusk hemocyanins have been used for decades in immunological and clinical applications as natural, nontoxic, nonpathogenic, and nonspecific immunostimulants for the treatment of superficial bladder cancer, as carriers/adjuvants of tumor-associated ...
Juan José Mora Román +11 more
doaj +2 more sources