Results 11 to 20 of about 1,731 (177)

Immunotherapeutic Potential of Mollusk Hemocyanins in Combination with Human Vaccine Adjuvants in Murine Models of Oral Cancer

Journal of Immunology Research, 2019
Mollusk hemocyanins have been used for decades in immunological and clinical applications as natural, nontoxic, nonpathogenic, and nonspecific immunostimulants for the treatment of superficial bladder cancer, as carriers/adjuvants of tumor-associated ...
Juan José Mora Román, Miguel Del Campo, Javiera Villar, Francesca Paolini, Gianfranca Curzio, Aldo Venuti, Lilian Jara, Jorge Ferreira, Paola Murgas, Alvaro Lladser, Augusto Manubens, María Inés Becker   +11 more
doaj   +2 more sources

The diversity and evolution of chelicerate hemocyanins [PDF]

BMC Evolutionary Biology, 2012
Background Oxygen transport in the hemolymph of many arthropod species is facilitated by large copper-proteins referred to as hemocyanins. Arthropod hemocyanins are hexamers or oligomers of hexamers, which are characterized by a high O2 transport ...
Rehm Peter, Pick Christian, Borner Janus, Markl Jürgen, Burmester Thorsten   +4 more
doaj   +2 more sources

The Structure of Arthropod Hemocyanins

Science, 1985
Hemocyanins are large multi-subunit copper proteins that transport oxygen in many arthropods and molluscs. Comparison of the amino acid sequence data for seven different subunits of arthropod hemocyanins from crustaceans and chelicerates shows many highly conserved residues and extensive regions of near identity.
Linzen, B., Soeter, N. M., Riggs, A. F., Schneider, H. J., Schartau, W., Moore, M. D., Yokota, E., Behrens, P. Q., Nakashima, H., Takagi, T., Nemoto, T., Vereijken, J. M., Bak, H. J., Beintema, J. J., Volbeda, A., Gaykema, W. P. J., Hol, W. G. J.   +16 more
openaire   +4 more sources

Antiviral activity of hemocyanins [PDF]

Invertebrate Survival Journal, 2013
Hemocyanins are giant biological macromolecules acting as oxygen-transporting glycoproteins. Most of them are respiratory proteins of arthropods and mollusks, but besides they also exhibit protecting effects against bacterial, fungal and viral invasions.
P Dolashka,, W Voelter
doaj   +3 more sources

Classification of polyphenol oxidases shows ancient gene duplication leading to two distinct enzyme types [PDF]

iScience
Summary: Polyphenol oxidases (PPOs) are coupled binuclear copper proteins that catalyze the oxidation of phenols. New functions of PPOs are continuously being discovered, latest with several fungal o-methoxy phenolases, which are active on lignin-derived
Ida K.S. Meitil, Caio de O.G. Silva, Anders Gorm Pedersen, Jane W. Agger   +3 more
doaj   +2 more sources

The evolution of hemocyanin genes in Tectipleura: a multitude of conserved introns in highly diverse gastropods [PDF]

BMC Ecology and Evolution, 2021
Background Hemocyanin is the oxygen transporter of most molluscs. Since the oxygen affinity of hemocyanin is strongly temperature-dependent, this essential protein needs to be well-adapted to the environment.
Gabriela Giannina Schäfer, Veronika Pedrini-Martha, Daniel John Jackson, Reinhard Dallinger, Bernhard Lieb   +4 more
doaj   +2 more sources

Venomics of Scorpion Ananteris platnicki (Lourenço, 1993), a New World Buthid That Inhabits Costa Rica and Panama [PDF]

Toxins
Ananteris is a scorpion genus that inhabits dry and seasonal areas of South and Central America. It is located in a distinctive morpho-group of Buthids, the ‘Ananteris group’, which also includes species distributed in the Old World.
Cecilia Díaz, Bruno Lomonte, Arturo Chang-Castillo, Fabián Bonilla, Adriana Alfaro-Chinchilla, Felipe Triana, Diego Angulo, Julián Fernández, Mahmood Sasa   +8 more
doaj   +2 more sources

Diverse immune functions of hemocyanins

Developmental & Comparative Immunology, 2014
Substantial evidence gathered recently has revealed the multiple functionalities of hemocyanin. Contrary to previous claims that this ancient protein is involved solely in oxygen transport within the hemolymph of invertebrates, hemocyanin and hemocyanin-derived peptides have been linked to key aspects of innate immunity, in particular, antiviral and ...
Coates, Christopher, Nairn, Jacqueline
openaire   +5 more sources

Preliminary Analysis of Hemocyanins in Hemolymph Plasma of Baikal Endemic Amphipods [PDF]

Journal of Stress Physiology & Biochemistry, 2016
Two-dimensional electrophoresis of plasma hemolymph proteins of several endemic Baikal amphipod species showed that, as expected, hemocyanin is the main major protein in plasma of these species.
D.S. Bedulina, A.N. Gurkov, B.K. Baduev, E.V. Borvinskaya, M.D. Dimova, M.A. Timofeyev   +5 more
doaj   +1 more source

Hemocyanins of Muricidae: New 'Insights' Unravel an Additional Highly Hydrophilic 800 kDa Mass Within the Molecule. [PDF]

J Mol Evol, 2021
Hemocyanins are giant oxygen transport proteins that freely float within the hemolymph of most molluscs. The basic quaternary structure of molluscan hemocyanins is a cylindrical decamer with a diameter of 35 nm which is built of 400 kDa subunits ...
Schäfer GG, Grebe LJ, Depoix F, Lieb B.
europepmc   +2 more sources