The diversity and evolution of chelicerate hemocyanins
BMC Evolutionary Biology, 2012 Background Oxygen transport in the hemolymph of many arthropod species is facilitated by large copper-proteins referred to as hemocyanins. Arthropod hemocyanins are hexamers or oligomers of hexamers, which are characterized by a high O2 transport ...
Rehm Peter +4 more
doaj +2 more sources
The structure of arthropod hemocyanins
Science, 1985 Hemocyanins are large multi-subunit copper proteins that transport oxygen in many arthropods and molluscs. Comparison of the amino acid sequence data for seven different subunits of arthropod hemocyanins from crustaceans and chelicerates shows many ...
Nakashima, H. +16 more
core +4 more sources
Antitumor Properties of Epitope-Specific Engineered Vaccine in Murine Model of Melanoma [PDF]
Marine Drugs, 2022 Finding new effective compounds of natural origin for composing anti-tumor vaccines is one of the main goals of antitumor research. Promising anti-cancer agents are the gastropodan hemocyanins–multimeric copper-containing glycoproteins used so far for ...
Emiliya Stoyanova +8 more
doaj +2 more sources
Antiviral activity of hemocyanins [PDF]
Invertebrate Survival Journal, 2013 Hemocyanins are giant biological macromolecules acting as oxygen-transporting glycoproteins. Most of them are respiratory proteins of arthropods and mollusks, but besides they also exhibit protecting effects against bacterial, fungal and viral invasions.
P Dolashka,, W Voelter
doaj +3 more sources
Pomacea canaliculata hemocyanin as a novel natural immunostimulant in mammals [PDF]
Frontiers in ImmunologyIntroductionGastropod hemocyanins are potent immunostimulants in mammals, a trait associated with their large molecular size and unusual glycosylation patterns.
Ignacio Rafael Chiumiento +13 more
doaj +2 more sources
Hemocyanins of Muricidae: New 'Insights' Unravel an Additional Highly Hydrophilic 800 kDa Mass Within the Molecule. [PDF]
J Mol Evol, 2021 Hemocyanins are giant oxygen transport proteins that freely float within the hemolymph of most molluscs. The basic quaternary structure of molluscan hemocyanins is a cylindrical decamer with a diameter of 35 nm which is built of 400 kDa subunits ...
Schäfer GG, Grebe LJ, Depoix F, Lieb B.
europepmc +2 more sources
European Journal of Immunology, 2021 Hemocyanins are used as immunomodulators in clinical applications because they induce a strong Th1-biased cell-mediated immunity, which has beneficial effects. They are multiligand glycosylated molecules with abundant and complex mannose-rich structures.
Javiera Villar +2 more
exaly +2 more sources
TLR4, but Neither Dectin-1 nor Dectin-2, Participates in the Mollusk Hemocyanin-Induced Proinflammatory Effects in Antigen-Presenting Cells From Mammals [PDF]
Frontiers in Immunology, 2019 Mollusk hemocyanins have biomedical uses as carriers/adjuvants and nonspecific immunostimulants with beneficial clinical outcomes by triggering the production of proinflammatory cytokines in antigen-presenting cells (APCs) and driving immune responses ...
José M. Jiménez +13 more
doaj +2 more sources
Classification of polyphenol oxidases shows ancient gene duplication leading to two distinct enzyme types [PDF]
iScienceSummary: Polyphenol oxidases (PPOs) are coupled binuclear copper proteins that catalyze the oxidation of phenols. New functions of PPOs are continuously being discovered, latest with several fungal o-methoxy phenolases, which are active on lignin-derived
Ida K.S. Meitil +3 more
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The evolution of hemocyanin genes in Tectipleura: a multitude of conserved introns in highly diverse gastropods [PDF]
BMC Ecology and Evolution, 2021 Background Hemocyanin is the oxygen transporter of most molluscs. Since the oxygen affinity of hemocyanin is strongly temperature-dependent, this essential protein needs to be well-adapted to the environment.
Gabriela Giannina Schäfer +4 more
doaj +2 more sources