Results 171 to 180 of about 29,542 (277)

CRISPR and Fanzor in sickle cell disease: current progress and future prospects. [PDF]

Front Genome Ed
Alhumoudi AY, Alotaibi AG, Alosaimi NF, Alshalani A, Alqahtani SM, Alsaab SM, Almutiri BJ, Albariqi MMH.   +7 more
europepmc   +1 more source

The Patient with Sickle Hemoglobin

The Journal of ExtraCorporeal Technology, 1973
Robert L. Richardson, Emily Taylor
openaire   +1 more source

Red blood cell membrane proteome as a reporter of disease severity, transfusion impact and genetic background in transfusion‐dependent β‐thalassaemia

British Journal of Haematology, Volume 208, Issue 6, Page 1980-1992, June 2026.
Summary Omics technologies have transformed research in haemoglobinopathies, yet the proteome of RBCs remains largely unexplored in transfusion‐dependent thalassaemia (TDT). In this proteomic analysis, Red blood cell (RBC) membranes from 48 adults with TDT were compared with healthy controls.
Konstantina Theocharaki, Sophia Delicou, Aikaterini Ntzoura‐Kani, Nikolaos Simantiris, Marianna Politou, Veroniki Komninaka, Martina Samiotaki, Jerome Zoidakis, Marianna H. Antonelou   +8 more
wiley   +1 more source

Sickle Cell Hepatic Vaso-Occlusive Crisis: A Case Report. [PDF]

Case Rep Hematol
Rambaran B.
europepmc   +1 more source

A genetic risk score based on BCL11A and HBS1L‐MYB variants predicts clinical severity in Brazilian sickle cell anaemia patients

British Journal of Haematology, Volume 208, Issue 6, Page 2203-2211, June 2026.
Summary Individuals with sickle cell anaemia (SCA) exhibit significant clinical heterogeneity influenced by several factors, especially fetal haemoglobin (HbF) levels. Variations in adult HbF levels are partly explained by the co‐inheritance of genetic variants that regulate globin expression.
Gabriela S. Arcanjo, Alexsandro P. Silva, Madi V. Diniz, Igor F. Domingos, Diego A. Pereira‐Martins, Amanda B. Araújo, Talita S. S. França, Ana C. Anjos, Aderson S. Araujo, Edis Belini‐Junior, Sara T. O. Saad, Fernando F. Costa, Antonio R. Lucena‐Araujo, Marcos André C. Bezerra   +13 more
wiley   +1 more source

Simplified Procedure for Isolation and Culture of Neuronal Cells from Brains of Sickle Cell Mice. [PDF]

Cells
Goel Y, Arellano MA, O'Daniel K, Argueta DA, Lomeli R, Lomeli N, Ordaz DA, Bota DA, Kumaresan V, Gupta K.   +9 more
europepmc   +1 more source

A Phase 1 Microtracer Study Evaluating the Mass Balance, Excretion, and Pharmacokinetics of Osivelotor in Healthy Participants

Clinical and Translational Science, Volume 19, Issue 6, June 2026.
ABSTRACT Osivelotor (GBT021601) is an orally bioavailable, small molecule hemoglobin polymerization inhibitor in clinical development for the treatment of sickle cell disease (SCD). In this Phase 1 study, the disposition of osivelotor was assessed using accelerator mass spectrometry (AMS) after a single oral 200‐mg dose containing a microtracer amount ...
Eric I. Zimmerman, Ernesto Callegari, Raman Sharma, Adeyemi Adenola, Jessica Volpe, Karthik Seetharaman, Chenghong Zhang, Kenneth Duchin, Gregory S. Walker   +8 more
wiley   +1 more source

Decoding thalassemia and sickle cell disease: advances in molecular technologies for comprehensive variant detection. [PDF]

Front Genet
Foord E, Sairafi D, Berg M, Westerling S, Adigun T, Uzunel M, Papasavva T, Uhlin M.   +7 more
europepmc   +1 more source

Sickle cell disease and fetal hemoglobin

Saudi Journal of Medicine and Medical Sciences, 2018
openaire   +3 more sources

Sickle cell disease implicated in the development of severe dengue: A pediatric case series. [PDF]

Rev Soc Bras Med Trop
Hernández MR, Suarez AG, Redondo HP, Moneriz C.   +3 more
europepmc   +1 more source