Results 61 to 70 of about 398,944 (237)

Effect of Red Blood Cell Transfusion on Inflammatory and Angiogenic Pathways in Patients With Sickle Cell Disease

American Journal of Hematology, EarlyView.
ABSTRACT Sickle cell disease (SCD) is a chronic inflammatory state, characterized by increased plasma values of inflammatory and angiogenic proteins. Although red blood cell (RBC) transfusion is known to have immunomodulatory effects in other conditions, its potential effects on the inflammatory state in SCD remain largely unknown.
Lydian A. de Ligt, Sanjay R. Thakoerdin, Maud Zwolsman, Gaby Stegemann, Hanke Matlung, Taco W. Kuijpers, Bart J. Biemond, Karin Fijnvandraat, Robin van Bruggen, Erfan Nur   +9 more
wiley   +1 more source

Clinico-hematological parameters of sickle hemoglobin hemoglobinopathies and its correlation with ethnicity: A study from Northern Districts of West Bengal

Biomedical and Biotechnology Research Journal, 2020
Background: Inherited disorders of blood include thalassemias and hemoglobinopathies which are one of the major public problems in India. In sickle hemoglobin (HbS) hemoglobinopathies, production of abnormal sickle-shaped red cells results in variable ...
Bidyut Krishna Goswami, Rajashri Chakrabarty, Subrata Bhattacharjee, Ankita Dhanuka, Sarama Banerjee Goswami, Sudipta Chakrabarti   +5 more
doaj   +1 more source

Post-Transcriptional Genetic Silencing of BCL11A to Treat Sickle Cell Disease.

New England Journal of Medicine, 2020
BACKGROUND Sickle cell disease is characterized by hemolytic anemia, pain, and progressive organ damage. A high level of erythrocyte fetal hemoglobin (HbF) comprising α- and γ-globins may ameliorate these manifestations by mitigating sickle hemoglobin ...
Erica B Esrick, L. Lehmann, A. Biffi, Maureen Achebe, C. Brendel, M. Ciuculescu, H. Daley, B. Mackinnon, Emily Morris, Amy Federico, D. Abriss, K. Boardman, R. Khelladi, K. Shaw, H. Negre, O. Nègre, S. Nikiforow, J. Ritz, S. Pai, W. London, C. Dansereau, M. Heeney, M. Armant, J. Manis, David A. Williams   +24 more
semanticscholar   +1 more source

Under the Shade of a Coolabah Tree: A Second Cache of Tulas From the Boulia District, Western Queensland

Archaeology in Oceania, EarlyView.
ABSTRACT This paper reports on the excavation of a cache of stone artefacts, buried on the bank of a waterhole or ‘billabong’ in central western Queensland. This is an extremely rare find, and yet it is the second such site to be reported within less than a 10 km radius.
Yinika L. Perston, Lynley A. Wallis, Heather Burke, Lorna Bogdanek, Trevina Rogers, Justine Kemp   +5 more
wiley   +1 more source

Unbinding of alpha chain of hemoglobin in sickle and normal structures

Journal of Physics Communications
Sickle cell disease, a genetic disorder, is caused by a mutation of glutamic acid into valine in β chain of hemoglobin at the sixth residue, resulting in structural change of the entire hemoglobin molecule into a sickle shape.
Jhulan Powrel, Rajendra Prasad Koirala, Narayan Prasad Adhikari   +2 more
doaj   +1 more source

Kinks, rings, and rackets in filamentous structures [PDF]

, 2003
Carbon nanotubes and biological filaments each spontaneously assemble into kinked helices, rings, and "tennis racket" shapes due to competition between elastic and interfacial effects.
A. E. Cohen, Amelinckx, Brazier, DeRosier, DeRosier, Dravid, Elbaum, Frank, Henon, L. Mahadevan, Poe, Sano, Sherman, Sleep, Srolovitz, Tersoff, Tilney, Wang, Winckler, Yakobson   +19 more
core   +2 more sources

Self‐Management Interventions in Young Adults (18–30 Years) With Type 1 Diabetes, Sickle Cell Disease, and Inflammatory Bowel Disease: A Scoping Review

Chronic Diseases and Translational Medicine, EarlyView.
ABSTRACT Fluctuating chronic conditions (FCC) in young adults aged 18–30 years, such as type 1 diabetes (T1D), sickle cell disease (SCD), and inflammatory bowel disease (IBD), present unique self‐management challenges due to unpredictable symptom patterns that disrupt daily life.
Reham Almabadi, Lawrence Doi, Colin Chandler, Huda Alamri   +3 more
wiley   +1 more source

Prevalence of hemolytic anemia and hemoglobinopathies among the pregnant women attending a tertiary hospital in central India

Thalassemia Reports, 2015
Anemia in pregnancy is one of the causes of maternal morbidity and, maternal and fetal mortality in India. Hemoglobin transports oxygen to different parts of the body. Any defect in hemoglobin structure leads to its adverse functions.
Ranbir S. Balgir
doaj   +1 more source

Catalytic Amyloids: Turning Fibrils Into Biocatalysts

Chemistry – A European Journal, EarlyView.
Amyloids, traditionally associated with diseases, have emerged as versatile catalytic scaffolds. From natural amyloid sequences to bioinspired and de novo designs, we highlight strategies to construct catalytic active sites and anchor enzymes onto fibrils, creating versatile nanomaterials with tunable activities. ABSTRACT Amyloids have been regarded as
Alessandra Esposito, Linda Leone, Flavia Nastri, Angela Lombardi   +3 more
wiley   +1 more source

Sickle cell disease status among school adolescents and their tribal community in South Gujarat [PDF]

, 2009
Objectives: to create awareness, to screen samples of school adolescents and then to reach their community through them by doing surveillance for sickle cell disease. Design: Field based cross-sectional study. Settings: St Xavier`s high school and Vanraj
Chudasama, Rajesh K, Godara, Naresh R, Srivastava, Ratan K, Vasava, Bipin   +3 more
core   +1 more source