Results 71 to 80 of about 29,542 (277)

Hydroxyurea Treatment for Sickle Cell Disease

The Scientific World Journal, 2002
High fetal hemoglobin (HbF) levels inhibit the polymerization of sickle hemoglobin (HbS) and reduce the complications of sickle cell disease. Pharmacologic agents that can reverse the switch from γ- to β-chain synthesis — γ-globin chains characterize HbF,
Martin H. Steinberg
doaj   +1 more source

Nitrosylation of Sickle Cell Hemoglobin by Hydroxyurea

, 2016
Nitrosylation of Sickle Cell Hemoglobin by ...
Yueping Xu (3045714), Genichiro Yasaki (3045711), Challice L. Bonifant (2535535), Daniel B. Kim-Shapiro (1912027), S. Bruce King (311467), Courtney D. Mull (3045708), Samir K. Ballas (792004), Eric C. Palmer (3045702), Howard Shields (3045705)   +8 more
core   +2 more sources

Thrombocytosis and the generation of platelet‐derived microparticles in the pathophysiology of sickle cell disease

British Journal of Haematology, EarlyView.
Thrombocytosis is associated with an increased production of platelet‐derived microparticles from activated platelets, which contribute to vaso‐occlusion in sickle cell disease by perpetuating the cycle of inflammation, procoagulant state and endothelial dysfunction.
Giao N. Lê, Anna Dillon, Owen P. Smith, Corrina McMahon   +3 more
wiley   +1 more source

Hemoglobinas variantes em doadores de sangue do Centro de Hematologia e Hemoterapia do estado do Piauí (Hemopi): conhecendo o perfil epidemiológico para construir a rede de assistência Hemoglobin S variants in blood donors of the Hematology and Hemotherapy Center of the state of Piauí (Hemopi): understanding the epidemiological profile to create a support network

Revista Brasileira de Hematologia e Hemoterapia, 2009
The most highly prevalent inherited disease in Brazil and in the world, sickle cell anemia, is considered a public health problem. Characterized by homozygosis for the hemoglobin S gene, the individual has a range of signs and symptoms that require ...
Leonardo F. Soares, Evaldo H. Oliveira, Iraildo B. Lima, José M. Silva, Jônathas T. Mota, Claudia R. Bonini-Domingos   +5 more
doaj   +1 more source

Hemoglobin sickle cell disease in Brazil

Haematologica, 2012
We read with great interest the recent paper presented by Lionnet et al .[1][1] and we would like to briefly report our experience with hemoglobin SC (HbSC) disease. Before the institution of neonatal screening in Brazil, HbSC disease was considered a rare manifestation.[2][2] After 2001, however,
Ana Carolina Cabañas-Pedro, Josefina A. P. Braga, Roberta F Camilo-Araújo, Ana I. M. Silva, Perla Vicari, Maria Figueiredo   +5 more
openaire   +3 more sources

Sickle Cell Amenia in association with α-thalassemia-2 : biosynthetic and hematological studies [PDF]

, 1978
Patients with Sickle Cell Anemia (SS) associated with homozygous α-thalassemia-2 (-α/-α; βs/βs) are difficult to detect because the in vitro synthesis of hemoglobin chains may be balanced after prolonged incubation (>120 min).
Huisman, Titus Hendrik Jan, Directors of Sickle Cell Centers Meeting, Felice, Alex   +2 more
core  

Association of haptoglobin levels with age, parasite density, and haptoglobin genotype in a malaria-endemic area of Gabon.

, 2006
Item does not contain fulltextHaptoglobin (Hp) levels were investigated in relation to host genotype in a malaria-endemic area in Gabon. A cross-sectional study of 1-12-year-old children was conducted in the rainy season, a period of high malaria ...
Michon, P., Deloron, P, Justice, A, Luty, A.J.F., Migot Nabias, Florence, Migot-Nabias, F, Imrie, H, Deloron, P., Justice, A., Deloron, Philippe, Fowkes, FJI, Michon, P, Luty, JF, Fowkes, F.J., Day, K.P., Imrie, H., Migot-Nabias, F., Day, KP, Fowkes, F.J.I   +18 more
core   +1 more source

Haplotype analyses of haemoglobin C and haemoglobin S and the dynamics of the evolutionary response to malaria in Kassena-Nankana District of Ghana. [PDF]

, 2012
BACKGROUND: Haemoglobin S (HbS) and C (HbC) are variants of the HBB gene which both protect against malaria. It is not clear, however, how these two alleles have evolved in the West African countries where they co-exist at high frequencies.
Kwadwo A. Koram (172174), Koram Kwadwo A., Oduro, AR, Wilson, Michael D, Ghansah Anita, Rogers William O., Abraham Hodgson, Ghansah, A, Dominic P. Kwiatkowski (106264), Abraham Hodgson (47097), Hodgson, A, Kirk A Rockett, Michael D Wilson, Michael D. Wilson, Kwiatkowski, DP, Kwadwo A. Koram, Oduro Abraham R., Hodgson, Abraham, Kwiatkowski, Dominic, Milligan Paul, Dominic P Kwiatkowski, William O. Rogers, Kwiatkowski Dominic P., Taane G Clark, Kirk A. Rockett, Ghansah, Anita, Taane G. Clark (106263), Rockett, KA, Anita Ghansah, Amenga-Etego Lucas, Koram, KA, Abraham R. Oduro, Dominic P. Kwiatkowski, Wilson Michael D., Rogers, William O, Taane G. Clark, Clark, Taane G, Clark, TG, Kwadwo A Koram, Abraham R. Oduro (172176), Paul Milligan (57142), Lucas Amenga-Etego, Koram, Kwadwo A, Thomas Anyorigiya (78750), Anyorigiya, Thomas, Kirk A. Rockett (138127), Paul Milligan, Rockett, Kirk A, Rogers, WO, Oduro, Abraham R, Wilson, MD, Amenga-Etego, Lucas, Anyorigiya, T, Michael D. Wilson (80451), William O. Rogers (172185), Hodgson Abraham, Milligan, Paul, Lucas Amenga-Etego (172180), Thomas Anyorigiya, Rockett Kirk A., Clark Taane G., Milligan, P, William O Rogers, Anita Ghansah (172168), Anyorigiya Thomas, Kwiatkowski, Dominic P, Amenga-Etego, L, Abraham R Oduro   +67 more
core   +1 more source

Hydroxyurea (hydroxycarbamide) use in adults with haemoglobin SC disease: A real‐world study in Quebec

British Journal of Haematology, EarlyView.
Summary Haemoglobin SC (HbSC) disease is the second most prevalent form of sickle cell disease, but evidence for hydroxyurea (hydroxycarbamide; HU) to prevent pain episodes was limited until the prospective identification of variables as outcomes for treatment (PIVOT) trial.
Alice Girard, Laurianne Charette, Mélissa Haouchine, Laurence Bozec, Mohamed Zakaria Bachir Bouyadjera, Mariane Poitras, Vincent‐Thierry Taillefer, Chloé Trudeau, Yves Pastore, Nathalie Letarte, Stéphanie Forté   +10 more
wiley   +1 more source

Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt

British Journal of Pharmacology, EarlyView.
Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown, Alan Armstrong, David J. Mann   +2 more
wiley   +1 more source