Results 81 to 90 of about 46,727 (267)

Evaluation of Glycated Albumin (GA) and GA/Hba1c Ratio for Diagnosis of Diabetes and Glycemic Control: A Comprehensive Review [PDF]

, 2017
Diabetes Mellitus (DM) is a group of metabolic diseases characterized by chronic high blood glucose concentrations (hyperglycemia). When it is left untreated or improperly managed, it can lead to acute complications including diabetic ketoacidosis and ...
Abdolrahim, Mojgan, Jazayeri, Hossein E., Rabiee, Mohammad, Rajab, Asodollah, Tahriri, Mohammadreza, Tayebi, Lobat, Yazdanpanah, Sara   +6 more
core   +3 more sources

Rapid turnover of T cells in acute infectious mononucleosis.

, 2003
During acute infectious mononucleosis (AIM), large clones of Epstein-Barr virus-specific T lymphocytes are produced. To investigate the dynamics of clonal expansion, we measured cell proliferation during AIM using deuterated glucose to label DNA of ...
Asquith, Becca, Beverley, Peter C, Ghattas, Hala, Griffin, George E, Irvine, Andrew J, Macallan, Derek C, Tough, David F, Wallace, Diana L, Worth, Andrew, Zhang, Yan   +9 more
core   +1 more source

Red blood cell membrane proteome as a reporter of disease severity, transfusion impact and genetic background in transfusion‐dependent β‐thalassaemia

British Journal of Haematology, EarlyView.
Summary Omics technologies have transformed research in haemoglobinopathies, yet the proteome of RBCs remains largely unexplored in transfusion‐dependent thalassaemia (TDT). In this proteomic analysis, Red blood cell (RBC) membranes from 48 adults with TDT were compared with healthy controls.
Konstantina Theocharaki, Sophia Delicou, Aikaterini Ntzoura‐Kani, Nikolaos Simantiris, Marianna Politou, Veroniki Komninaka, Martina Samiotaki, Jerome Zoidakis, Marianna H. Antonelou   +8 more
wiley   +1 more source

Prevalence of Low Bone Mineral Density Increases With Age in Sickle Cell Disease. [PDF]

EJHaem
ABSTRACT Introduction Skeletal complications are common in sickle cell disease (SCD). We previously showed that the prevalence of low areal bone mineral density (aBMD) increased with age in a pediatric SCD cohort, even after adjusting for short stature. Data on age‐related aBMD trends in young adults is lacking.
Gollamudi J, Wu C, Kang G, Lamonica MS, Chen PL, Srinivasan R, El-Bashir K, Hankins J, Rai P, Takemoto C, Hyacinth HI, Allen MR, Zemel BS, Adesina O.   +13 more
europepmc   +2 more sources

Synthesis and Screen of a Proline-Rich Combinatorial Library Towards the Identification of Sickle Cell Hemoglobin Polymerization Inhibitors [PDF]

, 2015
Sickle cell disease is a genetic disorder that affects the hemoglobin within red blood cells. A point mutation in the gene coding for the β-subunit of hemoglobin allows the mutant chain to interact with a hydrophobic pocket of another hemoglobin in a ...
Steenberge, Laura
core   +1 more source

Hemoglobin sickle cell disease in Brazil

Haematologica, 2012
We read with great interest the recent paper presented by Lionnet et al .[1][1] and we would like to briefly report our experience with hemoglobin SC (HbSC) disease. Before the institution of neonatal screening in Brazil, HbSC disease was considered a rare manifestation.[2][2] After 2001, however,
Ana Carolina Cabañas-Pedro, Josefina A. P. Braga, Roberta F Camilo-Araújo, Ana I. M. Silva, Perla Vicari, Maria Figueiredo   +5 more
openaire   +3 more sources

A genetic risk score based on BCL11A and HBS1L‐MYB variants predicts clinical severity in Brazilian sickle cell anaemia patients

British Journal of Haematology, EarlyView.
Summary Individuals with sickle cell anaemia (SCA) exhibit significant clinical heterogeneity influenced by several factors, especially fetal haemoglobin (HbF) levels. Variations in adult HbF levels are partly explained by the co‐inheritance of genetic variants that regulate globin expression.
Gabriela S. Arcanjo, Alexsandro P. Silva, Madi V. Diniz, Igor F. Domingos, Diego A. Pereira‐Martins, Amanda B. Araújo, Talita S. S. França, Ana C. Anjos, Aderson S. Araujo, Edis Belini‐Junior, Sara T. O. Saad, Fernando F. Costa, Antonio R. Lucena‐Araujo, Marcos André C. Bezerra   +13 more
wiley   +1 more source

Genetic variants and cell-free hemoglobin processing in sickle cell nephropathy

Haematologica, 2015
Intravascular hemolysis and hemoglobinuria are associated with sickle cell nephropathy. ApoL1 is involved in cell-free hemoglobin scavenging through association with haptoglobin-related protein.
Santosh L. Saraf, Xu Zhang, Binal Shah, Tamir Kanias, Krishnamurthy P. Gudehithlu, Rick Kittles, Roberto F. Machado, Jose A.L. Arruda, Mark T. Gladwin, Ashok K. Singh, Victor R. Gordeuk   +10 more
doaj   +1 more source

Invasive bacterial infections in Gambians with sickle cell anaemia in an era of widespread Pneumococcal and Haemophilus influenzae type B vaccination [PDF]

, 2016
Background: There is relatively little data on the aetiology of bacterial infections in patients with sickle cell anaemia (SCA) in West Africa, and no data from countries that have implemented conjugate vaccines against both Streptococcus pneumoniae and ...
Anderson, ST, Bah, G, Cunnington, A, Darboe, S, Lawal, B, Soothill, G   +5 more
core   +1 more source

Spot Test for Detection of Sickling Hemoglobin

Clinical Chemistry, 1972
Abstract We designed a simple spot-plate method for detecting sickling hemoglobins and distinguishing hemoglobin SS from AS in samples of dried blood on filter paper. The test depends on the differential solubility of sickling hemoglobins in phosphate solutions with and without 3 molar urea.
S, Kelly, L, Desjardins
openaire   +2 more sources