Results 251 to 260 of about 732,100 (298)

A Novel Sickle Hemoglobin: Hemoglobin S-South End

Journal of Pediatric Hematology/Oncology, 2004
Sickle hemoglobin (Hb S; beta Glu6Val) is due to an AGTG; beta Lys132Asn, AAA>AAC). When present alone, the beta Lys132Asn mutation has low oxygen affinity. Therefore, this mutation may enhance the polymerization of the Hb S variant. Furthermore, the variant hemoglobin mimics Hb A on high-pressure liquid chromatography, and its identity is not easily ...
Hong-Yuan, Luo, Adeboye H, Adewoye, Shawn H, Eung, Timothy P, Skelton, Karen, Quillen, Lillian, McMahon, Martin H, Steinberg, David H K, Chui   +7 more
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Hematuria in Hemoglobin S Disorders

Archives of Internal Medicine, 1980
Medical treatment of patients with hemoglobin S disorders severely tests the skill and judgment of their physicians. Dramatic and potentially serious symptoms and findings are common; the question is whether they are primary manifestations of the hemoglobinopathy (in which case conservative management is indicated) or whether they reflect serious ...
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Kinetics of polymerization of deoxyhemoglobin S and mixtures of hemoglobin A and hemoglobin S at high hemoglobin concentrations

Archives of Biochemistry and Biophysics, 1977
Abstract Transverse water proton relaxation times ( T 2 ) have been measured as a function of time after deoxygenation of solutions containing hemoglobin S. The shortened T 2 values observed upon deoxygenation of hemoglobin S result from an increase in the correlation time ( τ c ) of the water fraction irrotationally bound to deoxyhemoglobin S ...
G L, Cottam, M R, Waterman, B C, Thompson   +2 more
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Surface activity of hemoglobin S and other human hemoglobin variants

Biochimica et Biophysica Acta (BBA) - Protein Structure, 1976
The kinetics of surface pressure change (deltapi vs. t isotherms) were determined for several single point mutations of the human hemoglobin system. It was observed that hemoglobin S and hemoglobin CHarlem (both containing beta6 Glu leads to Val substitutions) have a specific behavior at the water-air interface: their extent of surface pressure change ...
D, Elbaum, J, Harrington, E F, Roth, R L, Nagel   +3 more
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Length distributions of hemoglobin S fibers

Journal of Molecular Biology, 1990
Electron microscopy of sickle cell hemoglobin fibers fixed at different times during gelation shows an exponential distribution of fiber lengths, with many short fibers and few long ones. The distribution does not change significantly with time as polymerization progresses.
R W, Briehl, E S, Mann, R, Josephs
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Oxygen equilibria of hemoglobin A and hemoglobin S valency hybrids

Archives of Biochemistry and Biophysics, 1977
Abstract Oxygen equilibrium determinations with “unsymmetrical” MetHb/Hb hybrids derived from human hemoglobins A and S are reported. All four of the possible hybrids have higher oxygen affinity than the parent hemoglobins. The α 2 Met β 2 S hybrid has a lower oxygen affinity than that of α 2 Met β 2 S .
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Fertility in Hemoglobin S-S and Hemoglobin S-C Disease

Fertility and Sterility, 1970
G D, Dunne, R R, Joseph
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Screening Reagent for Hemoglobin S (Hb S)

JAMA: The Journal of the American Medical Association, 1974
To the Editor.— Numerous screening modifications of the phosphate solubility test for hemoglobin S (Hb S) have been described (US Patent No. 3,492,095, 1970; J Clin Pathol 23:781, 1970 and 24:91, 1971; Am J Clin Pathol 58:11, 1971 and 59:300, 1973; Clin Chem 17:1028 and 1087, 1971; Summary Reports, ASCP , vol 8, August 1971; N Engl J Med 286:1143 ...
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Integrative oncology: Addressing the global challenges of cancer prevention and treatment

Ca-A Cancer Journal for Clinicians, 2022
Jun J Mao,, Msce, Lorenzo Cohen, Karen M Mustian   +2 more
exaly  

Rheological evaluation of hemoglobin S and hemoglobin C hemoglobinopathies.

The Journal of laboratory and clinical medicine, 1977
The concept of optimum hematocrit was used to compare the rheology of bloods from patients with various hemoglobin S and hemoglobin C hemoglobinopathies. The technique involved the utilization of cone and plate viscometric data to predict average flow rates under representative physiological-fluid mechanical conditions.
F, Self, L V, McIntire, B, Zanger
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