Results 251 to 260 of about 732,010 (281)

Hemoglobin S-G (S-D) syndrome

The American Journal of Medicine, 1974
Abstract Two subjects are described who had positive sickle cell preparations and routine alkaline electrophoretic patterns showing only hemoglobins S, F and A 2 . Although this combination suggests sickle cell anemia, their hemoglobin separated into two major bands on agar gel electrophoresis using a citrate buffer, pH 6.2. The non-S hemoglobins were
P R, McCurdy, P A, Lorkin, R, Casey, H, Lehmann, D E, Uddin, L G, Dickson   +5 more
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Hemoglobin S-D Disease

Annals of Internal Medicine, 1966
Excerpt Itano (1) first described hemoglobin D in 1951 in a Caucasian family who had hemoglobin S interacting with D. Hemoglobin D was the fifth hemoglobin to be described.
M J, Cawein, E J, Lappat, R W, Brangle, C H, Farley   +3 more
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A Novel Sickle Hemoglobin: Hemoglobin S-South End

Journal of Pediatric Hematology/Oncology, 2004
Sickle hemoglobin (Hb S; beta Glu6Val) is due to an AGTG; beta Lys132Asn, AAA>AAC). When present alone, the beta Lys132Asn mutation has low oxygen affinity. Therefore, this mutation may enhance the polymerization of the Hb S variant. Furthermore, the variant hemoglobin mimics Hb A on high-pressure liquid chromatography, and its identity is not easily ...
Hong-Yuan, Luo, Adeboye H, Adewoye, Shawn H, Eung, Timothy P, Skelton, Karen, Quillen, Lillian, McMahon, Martin H, Steinberg, David H K, Chui   +7 more
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Hematuria in Hemoglobin S Disorders

Archives of Internal Medicine, 1980
Medical treatment of patients with hemoglobin S disorders severely tests the skill and judgment of their physicians. Dramatic and potentially serious symptoms and findings are common; the question is whether they are primary manifestations of the hemoglobinopathy (in which case conservative management is indicated) or whether they reflect serious ...
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Kinetics of polymerization of deoxyhemoglobin S and mixtures of hemoglobin A and hemoglobin S at high hemoglobin concentrations

Archives of Biochemistry and Biophysics, 1977
Abstract Transverse water proton relaxation times ( T 2 ) have been measured as a function of time after deoxygenation of solutions containing hemoglobin S. The shortened T 2 values observed upon deoxygenation of hemoglobin S result from an increase in the correlation time ( τ c ) of the water fraction irrotationally bound to deoxyhemoglobin S ...
G L, Cottam, M R, Waterman, B C, Thompson   +2 more
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Surface activity of hemoglobin S and other human hemoglobin variants

Biochimica et Biophysica Acta (BBA) - Protein Structure, 1976
The kinetics of surface pressure change (deltapi vs. t isotherms) were determined for several single point mutations of the human hemoglobin system. It was observed that hemoglobin S and hemoglobin CHarlem (both containing beta6 Glu leads to Val substitutions) have a specific behavior at the water-air interface: their extent of surface pressure change ...
D, Elbaum, J, Harrington, E F, Roth, R L, Nagel   +3 more
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Length distributions of hemoglobin S fibers

Journal of Molecular Biology, 1990
Electron microscopy of sickle cell hemoglobin fibers fixed at different times during gelation shows an exponential distribution of fiber lengths, with many short fibers and few long ones. The distribution does not change significantly with time as polymerization progresses.
R W, Briehl, E S, Mann, R, Josephs
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Oxygen equilibria of hemoglobin A and hemoglobin S valency hybrids

Archives of Biochemistry and Biophysics, 1977
Abstract Oxygen equilibrium determinations with “unsymmetrical” MetHb/Hb hybrids derived from human hemoglobins A and S are reported. All four of the possible hybrids have higher oxygen affinity than the parent hemoglobins. The α 2 Met β 2 S hybrid has a lower oxygen affinity than that of α 2 Met β 2 S .
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Fertility in Hemoglobin S-S and Hemoglobin S-C Disease

Fertility and Sterility, 1970
G D, Dunne, R R, Joseph
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