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Paroxysmal Nocturnal Hemoglobinuria [PDF]
Blood, 2014 AbstractParoxysmal nocturnal hemoglobinuria (PNH) is a rare bone marrow failure disorder that manifests with hemolytic anemia, thrombosis, and peripheral blood cytopenias. The absence of two glycosylphosphatidylinositol (GPI)-anchored proteins, CD55 and CD59, leads to uncontrolled complement activation that accounts for hemolysis and other PNH ...
Mitchell Tublin +5 more
openaire +3 more sources
COVID‐19 infection presenting as paroxysmal nocturnal hemoglobinuria [PDF]
Clinical Case Reports, 2021 A diagnosis of paroxysmal nocturnal hemoglobinuria (PNH) was elicited during acute COVID‐19 infection. COVID‐19 spike proteins trigger the alternative pathway of complement. Acute SARS‐CoV‐2 infection possibly expanded an existing PIG‐A mutation.
Adam Hines +2 more
semanticscholar +4 more sources
Journal of Nepal Medical Association, 2021 Paroxysmal nocturnal hemoglobinuria can rarely present as cerebral ischemia and stroke due to arterial thrombosis. However, it should be considered in a young patient with bone marrow failure features, systemic thromboses, and hemolysis.
Ayushma Acharya +3 more
doaj +2 more sources
Paroxysmal nocturnal hemoglobinuria revealed by atypical thromboses: A case of cerebral, hepatic, and portal vein involvement leading to cirrhosis [PDF]
Radiology Case ReportsParoxysmal nocturnal hemoglobinuria is a rare clonal stem cell disorder characterized by ongoing intravascular hemolysis, frequent bone marrow dysfunction, and a markedly elevated risk of thrombosis.
Majda Malghi, MD +6 more
doaj +2 more sources
Paroxysmal Nocturnal Hemoglobinuria
Journal of Nepal Medical Association, 2005 Paroxysmal nocturnal hemoglobinuria (PNH) is a rare hemolytic disorder of acquired origin and is clinically manifested by chronic hemolysis, thromboses in various sites, and bone marrow failure.
Buddhi P Paudyal +4 more
doaj +6 more sources
Short-term recurrent coronary artery thrombosis with acute myocardial infarction in a patient with aplastic anemia–paroxysmal nocturnal hemoglobinuria syndrome: a case report [PDF]
Frontiers in Cardiovascular MedicineBackgroundAcute myocardial infarction commonly occurs in patients with coronary artery disease, but rarely, it can develop under a hypercoagulable state.
Xue-Guo Fu +3 more
doaj +2 more sources
Meningococcal Sepsis in Patient with Paroxysmal Nocturnal Hemoglobinuria during Pegcetacoplan Therapy [PDF]
Emerging Infectious DiseasesComplement C5 inhibitors bring an increased risk for Neisseria infections. A novel complement C3 inhibitor, pegcetacoplan, was recently approved to treat paroxysmal nocturnal hemoglobinuria, a condition commonly treated with complement C5 inhibitors. We
Leo Starck +8 more
doaj +2 more sources
A rare case of littoral cell angioma with paroxysmal nocturnal hemoglobinuria. [PDF]
Medicine (Baltimore)Li Z, Zhang S, Wu J, Du Z, Niu S.
europepmc +2 more sources
Frontiers in Physiology, 2021 BackgroundThe coronavirus disease-2019 (COVID-19) pandemic impacted healthcare services for kidney disease patients. Lockdown and social distancing were mandated worldwide, resulting in closure of medical services.
Samy Hakroush +3 more
doaj +1 more source
Blackwater Fever Treated with Steroids in Nonimmune Patient, Italy
Emerging Infectious Diseases, 2023 Causes of blackwater fever, a complication of malaria treatment, are not completely clear, and immune mechanisms might be involved. Clinical management is not standardized.
Anna Rita Di Biase +7 more
doaj +1 more source