Results 71 to 80 of about 13,066 (196)

Immune‐Mediated Thrombocytopenia in an Ulcerative Colitis Patient After Initiating Filgotinib Treatment: A Case Report

Clinical Case Reports, Volume 14, Issue 1, January 2026.
Timeline of events ABSTRACT Moderate‐to‐severe ulcerative colitis can be effectively treated with JAK‐1 inhibition, but platelet counts should be closely monitored, especially in active disease. We confirmed immune‐mediated thrombocytopenia (ITP) in one of our patients after the initiation of filgotinib. Whether this was drug‐induced is uncertain.
M. J. van der Hoff, F. El‐Morabit, M. Löwenberg   +2 more
wiley   +1 more source

Increased Circulating Soluble Cd14 Is Associated With High Mortality In Gram-Negative Septic Shock [PDF]

, 2017
The soluble glycoprotein sCD14 binds lipopolysaccharide, a complex that activates endothelial cells and that may be crucial in gram-negative sepsis, Therefore, serum sCD14 was analyzed in 54 patients with gram-negative septic shock and in 26 healthy ...
Calandra, Thierry, Glauser, Michel Pierre, Hahn, Alfred, Landmann, Regine, Link, Susanne, Sansano, Sebastiano, Zimmerli, Werner   +6 more
core  

Aki associated with macroscopic glomerular hematuria: Clinical and pathophysiologic consequences [PDF]

, 2012
Hematuria is a common finding in various glomerular diseases. This article reviews the clinical data on glomerular hematuria and kidney injury, as well as the pathophysiology of hematuria-associated renal damage.
Alberto Ortiz, August, Catalina Martín-Cleary, Clark, Clarkson, Cleary, Delclaux, Eduardo Gutiérrez, Feith, Fogazzi, Hebbel, Heyman, Hill, Hirsch, Honda, Jesús Egido, Juan Antonio Moreno, Kincaid-Smith, Kincaid-Smith, Luis Miguel Blanco-Colio, Manuel Praga, Nath, Nath, Ortiz de Montellano, Oscar Toldos, Pace-Asciak, Praga, Reeder, Shah, Vaziri   +29 more
core   +2 more sources

MUC4 mutations promote a thrombotic phenotype in patients with paroxysmal nocturnal haemoglobinuria by increasing the deposition of terminal complement

Clinical and Translational Medicine, Volume 16, Issue 1, January 2026.
1. PNH patients lack the complement regulatory proteins CD55 and CD59, triggering excessive activation of the terminal complement pathway and a prothrombotic state. 2. MUC4 mutation is an independent thrombotic risk factor in PNH. 3. Mutation/down‐regulation of MUC4 promotes the abnormal deposition of excessively activated terminal complement ...
Yingying Chen, Mengting Che, Chaomeng Wang, Qiaoyi Bronte Zhang, Weixin Chen, Hui Liu, Chunyan Liu, Guang Sheng Ling, Rong Fu   +8 more
wiley   +1 more source

Pregnancy in Classical Paroxysmal Nocturnal Hemoglobinuria and Aplastic Anemia–Paroxysmal Nocturnal Hemoglobinuria: A High-Risk Constellation

Frontiers in Medicine, 2020
Pregnancies in paroxysmal nocturnal hemoglobinuria (PNH) are associated with increased morbidity and mortality. Retrospective studies suggest that outcome has improved with the advent of the complement inhibitor eculizumab.
Ferras Alashkar, Fuat H. Saner, Colin Vance, Ute Schmücker, Dörte Herich-Terhürne, Ulrich Dührsen, Angela Köninger, Alexander Röth   +7 more
doaj   +1 more source

Paroxysmal nocturnal hemoglobinuria: A rare case of recurrent episodes of icterus

Acta Medica Martiniana, 2022
In this work we describe a rare case of a patient with paroxysmal nocturnal hemoglobinuria (PNH) developed on the background of specific medical history of morbus Gilbert with chronically elevated bilirubin and recurrent attacks of macroscopic haematuria.
Jakub Hoferica, Lenka Nosakova, Peter Uhrik, Diana Vazanova, Matus Scur, Juraj Chudej, Peter Banovcin   +6 more
doaj   +1 more source

Paroxysmal Nocturnal Hemoglobinuria [PDF]

Blood, 1956
Abstract 1. A fatal case of P.N.H. in a woman of 65 is presented. 2. The subject of P.N.H. is briefly discussed, and 3. The involvement of the bone marrow in the disease process is stressed.
A. M. NUSSEY, D. W. DAWSON
openaire   +1 more source

Improvement in survival of patients with higher risk but not lower risk myelodysplastic syndromes over 20 years: A retrospective study from Nagasaki, Japan

British Journal of Haematology, EarlyView.
Takafumi Furumoto, Koji Ando, Eo Toriyama, Tomoko Hata, Hikaru Sakamoto, Masahiko Chiwata, Hideaki Kitanosono, Jun Nakashima, Takeharu Kato, Masataka Taguchi, Makiko Horai, Hidehiro Itonaga, Shinya Sato, Yasushi Sawayama, Daisuke Imanishi, Yoshitaka Imaizumi, Tatsuro Jo, Shinichiro Yoshida, Yukiyoshi Moriuchi, Yasushi Miyazaki   +19 more
wiley   +1 more source

Validation of a candidate international harmonisation protocol‐compliant measurement procedure for reticulocyte counting using an erythrocyte gating strategy excluding the platelet component

Cytometry Part B: Clinical Cytometry, Volume 110, Issue 1, Page 47-56, January 2026.
Abstract The International Harmonisation Protocol (IHP) for Reticulocyte Percentage (%Retic) in CLSI‐H44‐A2 is a microscopic procedure performed on a new‐methylene‐blue‐stained blood film (NMB‐IHP). However, IHP‐compliant Measurement Procedures (MPs) based on flow cytometry (FCM) are recommended for practical and accurately assigned reference values ...
Yutaka Nagai, Tomohiro Takeda, Hiromichi Matsushita, Tomoko Arai, Yoko Yatabe, Hiromitsu Yokota, Takayuki Mitsuhashi, Masatoshi Wakui, Yohko Kawai, Hiroshi Kondo   +9 more
wiley   +1 more source

Clinical studies on iron metabolism of erythroblasts in preleukemic stage [PDF]

, 1974
The appearance of sideroblasts in hypoplastic anemia (HAl and acute myelocytic leukemia (AML), together with their sideroblastograms, was studied. Hematological studies on cases with type III sideroblast dominance by sideroblastograms produced the ...
Kimura, Ikuro, Sugiyama, Motoharu, Takahashi, lsao   +2 more
core   +1 more source