Results 11 to 20 of about 22,483 (254)
Porcine Babesiosis Caused by Babesia sp. Suis in a Pot-Bellied Pig in South Africa
Frontiers in Veterinary Science, 2021 Babesiosis is a worldwide, tick-borne disease of economic importance in livestock caused by Babesia spp., which are hemoparasitic piroplasms that target the host erythrocytes.
Alida Avenant +4 more
doaj +1 more source
Pegcetacoplan versus Eculizumab in Paroxysmal Nocturnal Hemoglobinuria.
New England Journal of Medicine, 2021 BACKGROUND Paroxysmal nocturnal hemoglobinuria (PNH) is a rare, acquired disease characterized by chronic complement-mediated hemolysis. C5 inhibition controls intravascular hemolysis in untreated PNH but cannot address extravascular hemolysis ...
P. Hillmen +18 more
semanticscholar +1 more source
Renal hemosiderosis in paroxysmal nocturnal hemoglobinuria
Revista de Medicina da UFC, 2022 A previously healthy 38-year-old man presented with history of fever, adynamia and anemia for the last 5 months. Physical examination revealed pallor. Laboratory was marked by a hemoglobin level of 9.2g per deciliter (reference range, 14.0 to 18.0 g per ...
Italo Gustavo Lima Monteiro +2 more
doaj +1 more source
Paroxysmal nocturnal hemoglobinuria: Where are we going
American journal of hematology/oncology, 2023 Paroxysmal nocturnal hemoglobinuria (PNH) is a rare nonmalignant clonal hematological disorder that is characterized by a deficiency of the GPI‐linked complement regulators on the membrane of hematopoietic cells, which renders them susceptible to ...
A. Kulasekararaj, I. Lazana
semanticscholar +1 more source
Oman Medical Journal, 2022 We aimed to estimate the nature and prevalence of paroxysmal nocturnal hemoglobinuria (PNH) among Omani patients. We performed a retrospective review of all patients who were tested for PNH by flow cytometry at the Sultan Qaboos University Hospital ...
Arwa Z. Al-Riyami +7 more
doaj +1 more source
Blood Advances, 2023 Key Points • Complement inhibitor–naive patients with PNH had greater hemoglobin stabilization and LDH reduction with pegcetacoplan vs control.• Pegcetacoplan’s comprehensive control of hemolysis and favorable safety profile in these patients may help ...
R. Wong +14 more
semanticscholar +1 more source
Paroxysmal Nocturnal Hemoglobinuria: Current Management, Unmet Needs, and Recommendations
Journal of Blood Medicine, 2023 Paroxysmal nocturnal hemoglobinuria (PNH) is an ultra-rare, acquired clonal abnormality, which renders hematopoietic cells exquisitely sensitive to complement-mediated destruction.
Monika Oliver, Christopher J. Patriquin
semanticscholar +1 more source
Blood Advances, 2022 Iptacopan (LNP023) is a novel, oral selective inhibitor of complement factor B under clinical development for paroxysmal nocturnal hemoglobinuria (PNH).
J. Jang +9 more
semanticscholar +1 more source
How I Treat Paroxysmal nocturnal hemoglobinuria.
Blood, 2021 Paroxysmal nocturnal hemoglobinuria (PNH) is a rare, clonal, complement-mediated hemolytic anemia with protean manifestations. PNH can present as a hemolytic anemia, a form of bone marrow failure, a thrombophilia, or any combination of the above ...
R. Brodsky
semanticscholar +1 more source
Paroxysmal nocturnal hemoglobinuria: Where we stand
American journal of hematology/oncology, 2023 For the last 20 years, therapy of paroxysmal nocturnal hemoglobinuria (PNH) relied—up until recently—on antibody based terminal complement inhibitionon.
J. Panse
semanticscholar +1 more source