Results 21 to 30 of about 22,483 (254)
Silicone Oil Decreases Biofilm Formation in a Capacitance-Based Automatic Urine Measurement System
Sensors, 2021 Capacitance-based automatic urine measurement is a validated technique already implemented in clinical practice. However, albuminuria and free hemoglobinuria cause progressive biofilm buildup on the capacitance sensors of the urinometers. The aim of this
Martin Slettengren +2 more
doaj +1 more source
eJHaem, 2023 Complement dysregulation underpins the physiopathology of paroxysmal nocturnal hemoglobinuria (PNH). Cemdisiran, an RNA interference investigational treatment, silences complement component 5 (C5) expression in the liver.
A. Gaya +10 more
semanticscholar +1 more source
Clinical and epidemiological features of paroxysmal cold hemoglobinuria: a systematic review
Blood Advances, 2023 Key Points • Among 230 reported cases, contemporary PCH has a median onset age of 5 years with no sex predilection.• PCH is associated with significant variability in DAT results, necessitating high clinical suspicion and DL testing.
J. Jacobs +5 more
semanticscholar +1 more source
European Journal of Haematology, 2022 The complement component 5 (C5) inhibitor ravulizumab demonstrated non‐inferiority to eculizumab following 26 weeks of treatment in complement inhibitor‐naïve and complement inhibitor‐experienced patients with paroxysmal nocturnal hemoglobinuria (PNH ...
A. Kulasekararaj +10 more
semanticscholar +1 more source
Immunological Reviews, 2022 Paroxysmal nocturnal hemoglobinuria (PNH) is a rare clonal, not malignant, hematological disease characterized by intravascular hemolysis, thrombophilia and bone marrow failure.
A. Risitano +3 more
semanticscholar +1 more source
Blood, 1953 Abstract 1. A case of hemoglobinemia and hemoglobinuria with recovery following incomplete drowning is presented. 2. The pathogenesis of the intravascular hemolysis is discussed.
openaire +2 more sources
Annals of Hematology, 2022 Paroxysmal nocturnal hemoglobinuria (PNH) is a rare, acquired hematologic disorder characterized by complement-mediated hemolysis. C5 inhibitors (eculizumab/ravulizumab) control intravascular hemolysis but do not prevent residual extravascular hemolysis.
R. Wong +16 more
semanticscholar +1 more source
Consensus statement for diagnosis and treatment of paroxysmal nocturnal haemoglobinuria
Hematology, Transfusion and Cell Therapy, 2021 Paroxysmal nocturnal hemoglobinuria is a chronic, multi-systemic, progressive and life-threatening disease characterized by intravascular hemolysis, thrombotic events, serious infections and bone marrow failure.
Rodolfo D. Cançado +8 more
doaj +1 more source
Blood, 2021 Some patients with paroxysmal nocturnal hemoglobinuria (PNH) remain persistently anemic despite treatment with eculizumab and may have significant extravascular hemolysis.
Austin Kulesekararaj +8 more
semanticscholar +1 more source
The Tohoku Journal of Experimental Medicine, 1975 A 16 years old boy had a typical exertional hemoglobinuria after walking with his new leather shoes on. The attacks of hemoglobinuria were associated with the appearance of an unstable hemoglobin in red cells. A slightly decreased fragility curve by 24 hr incubated red cells, the increase of autohemolysis and the appearance of heat labile hemoglobin ...
YASUHICO OHNO +6 more
openaire +3 more sources