Results 71 to 80 of about 22,483 (254)

Hemoglobinuria paroxística

Acta Médica Peruana
Se han estudiado cinco casos de hemoglobinuria paroxística nocturna. En cuatro de ellos la enfermedad se manifiesta en su forma clásica y en uno se muestra más como "defecto" que como enfermedad.
Jorge F. Castillo A. , Augusta M. Rojas, Alipio Jeri, Edda H. de Aguayo   +3 more
doaj   +1 more source

Upregulation of Checkpoint Ligand Programmed Death-Ligand 1 in Patients with Paroxysmal Nocturnal Hemoglobinuria Explained by Proximal Complement Activation [PDF]

, 2022
Markus Anliker, Daniela Drees, Lorin Loacker, Susanne Häfner, Andrea Griesmacher, Gregor Hoermann, Vilmos Fux, Harald Schennach, Paul Hörtnagl, Arthur Dopler, Stefan Schmidt, Rosa Bellmann‐Weiler, Günter Weiß, Astrid Marx‐Hofmann, Sixten Körper, Britta Höchsmann, Hubert Schrezenmeier, Christoph Q. Schmidt   +17 more
openalex   +1 more source

Paroxysmal nocturnal hemoglobinuria: current treatments and unmet needs

Journal of Managed Care & Specialty Pharmacy, 2020
The current standard of care for paroxysmal nocturnal hemoglobinuria (PNH) are the C5 inhibitors eculizumab and ravulizumab, both monoclonal antibodies designed to target the complement protein C5, thereby preventing its cleavage and the formation of the
M. Bektas, C. Copley-Merriman, Shahnaz Khan, S. Sarda, J. Shammo   +4 more
semanticscholar   +1 more source

Sutimlimab in Patients With Cold Agglutinin Disease (CAD): Results From a Managed Access Program

European Journal of Haematology, EarlyView.
ABSTRACT Cold agglutinin disease (CAD) is a low‐grade lymphoproliferative disorder accounting for 15%–30% of patients suffering from autoimmune hemolytic anemias. The clonal B cells produce autoantibodies primarily of the IgM‐κ class that cause agglutination of red blood cells (RBCs) at temperatures ≤ 37°C and activate the classical complement pathway ...
Sandra Maria Frey, Pauline Halberstadt, Ferras Alashkar, Veronika Lenz, H. Christian Reinhardt, Alexander Röth   +5 more
wiley   +1 more source

The PNH French Working Group Experience: Building a Strong Network of Cytometrists

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Introduction The PNH working group was created in 2010 to initiate a workshop on testing white blood cells to share international recommendations. Methods Thirty‐five French and Belgian laboratories equipped with 2‐ or 3‐laser cytometers applied three different panels with or without FLAER reagent in 305 samples.
Orianne Wagner‐Ballon, Magali Le Garff‐Tavernier, Rémi Lestestu, Bernard Drenou, Agathe Debliquis, the PNH French Working Group «CytHem‐HPN», Chantal Fossat, Claire Loosen, Bernard Chatelain, Marie Loosveld   +9 more
wiley   +1 more source

Small-molecule factor D inhibitors selectively block the alternative pathway of complement in paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome

Haematologica, 2017
Paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome are diseases of excess activation of the alternative pathway of complement that are treated with eculizumab, a humanized monoclonal antibody against the terminal complement ...
Xuan Yuan, Eleni Gavriilaki, Jane A. Thanassi, Guangwei Yang, Andrea C. Baines, Steven D. Podos, Yongqing Huang, Mingjun Huang, Robert A. Brodsky   +8 more
doaj   +1 more source

Classification of Platelet‐Activating Anti‐Platelet Factor 4 Disorders

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Introduction The prototypic anti‐platelet factor 4 (PF4) disorder—heparin‐induced thrombocytopenia and thrombosis (HITT)—features immunoglobulin G (IgG) class antibodies that activate platelets, monocytes, and neutrophils in a mainly heparin‐dependent fashion via Fcγ receptor‐dependent cellular activation.
Theodore E. Warkentin
wiley   +1 more source

Outbreak of simultaneous poisoning by Froelichia humboldtiana (Roem. & Schult.) Seub and Indigofera suffruticosa in ruminants in the Sertão of Pernambuco, Brazil

Arquivo Brasileiro de Medicina Veterinária e Zootecnia
The occurrence of outbreak of poisoning due to a combination of plants is uncommon worldwide, and there are no records of similar cases in Brazil. An outbreak of poisoning by Froelichia humboldtiana and Indigofera suffruticosa in ruminants in the Sertão ...
C.A.O. Oliveira, J.K.A. Melo, D.C. Silva, K.C. Rocha, S.F. Lira, W.F. Souza, L.C.F. Baptista-Filho, T.R.R. Ramos   +7 more
doaj   +1 more source

Paroxysmal nocturnal hemoglobinuria in systemic lupus erythematosus: a case report

Journal of Medical Case Reports, 2011
Introduction Paroxysmal nocturnal hemoglobinuria is an acquired disorder of hemopoiesis and is characterized by recurrent episodes of intravascular hemolysis due to an increased sensitivity to complement-mediated hemolysis.
Nakamura Norio, Sugawara Toshiyuki, Shirato Ken-ichi, Kumasaka Ryuichiro, Nakamura Masayuki, Shimada Michiko, Fujita Takeshi, Murakami Reiichi, Shimaya Yuko, Osawa Hiroshi, Yamabe Hideaki, Okumura Ken   +11 more
doaj   +1 more source

Paroxysmal Nocturnal Hemoglobinuria [PDF]

Blood, 1950
Abstract 1. Paroxysmal noctural hemoglobinuria is believed to be an acquired disease of the hematopoietic system in which abnormal red cells, white cells, and platelets are produced. The lesion of the cells probably involves the stromal proteins in such a fashion that they are susceptible to the proteolytic effect of a sytem of normal ...
openaire   +2 more sources