Marstacimab for the Treatment of Hemophilia A or B
Biologics: Targets and TherapyHemophilia A and B, caused by deficiencies of coagulation factors VIII or IX, result in impaired thrombin generation with consequent spontaneous or trauma-related bleeding, particularly hemarthroses. Although prophylactic factor replacement therapy remains the global standard of care for hemophilia, it has significant limitations, including intravenous
openaire +2 more sources
Management of pregnancy and childbirth in Glanzmann thrombasthenia: A case series and review
British Journal of Haematology, Volume 207, Issue 4, Page 1702-1708, October 2025.To illustrate the challenges in the management of women with Glanzmann thrombasthenia (GT) planning a pregnancy, we conducted a literature review and present a case series of eight women giving detailed descriptions of reproductive health problems, platelet alloimmunisation, treatment to prevent post‐partum haemorrhage and neonatal outcomes.
Karlijn H. G. Rutten +9 more
wiley +1 more source
Evaluating the Safety and Efficacy of Concizumab in Hemophilia A/B Patients: A Systematic Review
Clinical and Applied Thrombosis/HemostasisBackground Hemophilia A and B are X-linked recessive bleeding disorders caused by deficiencies of coagulation factors VIII and IX, respectively. These conditions lead to spontaneous bleeding, joint damage, inhibitor development, and the burden of ...
Erum Siddiqui MBBS +5 more
doaj +1 more source
Nine independentF9 mutations in the Mexican hemophilia B population: Nonrandom recurrences of point mutation events in the human germline [PDF]
, 2000 Ana Rebeca Jaloma‐Cruz +9 more
openalex +1 more source
The Roles and Clinical Significance of Major Hepatic‐Derived Metabolites in Hepatocellular Carcinoma
Journal of Gastroenterology and Hepatology, Volume 40, Issue 10, Page 2435-2448, October 2025.ABSTRACT Hepatocellular carcinoma (HCC) is increasingly recognized as a metabolically orchestrated malignancy, in which hepatic‐derived metabolites function not only as byproducts of liver physiology but also as active modulators of tumor biology.
Rui Sun +5 more
wiley +1 more source
Liver International, Volume 45, Issue 10, October 2025.ABSTRACT Introduction Spontaneous rupture of hepatocellular carcinoma (SRHCC) presents a critical clinical challenge, with early haemostasis often difficult to achieve and limited data available on subsequent treatment strategies. This study aims to evaluate whether the initial hemostatic approach influences early prognosis and facilitates further ...
Apolline Commin +22 more
wiley +1 more source
Sustained and Complete Phenotype Correction of Hemophilia B Mice Following Intramuscular Injection of AAV1 Serotype Vectors [PDF]
, 2001 Hengjun Chao +4 more
openalex +1 more source
Muscle-Directed Gene Transfer and Transient Immune Suppression Result in Sustained Partial Correction of Canine Hemophilia B Caused by a Null Mutation [PDF]
, 2001 Roland W. Herzog +4 more
openalex +1 more source
Gene therapy with adeno-associated virus vector 5-human factor IX in adults with hemophilia B.
Blood, 2018 Wolfgang A. Miesbach +13 more
semanticscholar +1 more source