Results 91 to 100 of about 18,147 (215)

Gene Therapy for Cardiovascular Disease [PDF]

, 2003
The last decade has seen substantial advances in the development of gene therapy strategies and vector technology for the treatment of a diverse number of diseases, with a view to translating the successes observed in animal models into the clinic ...
Baker, Andrew H., Denby, Laura, Dishart, Kate L., Work, Lorraine M.   +3 more
core   +4 more sources

Autologous haematopoietic stem cell transplantation for multiple sclerosis in the UK: A 20‐year retrospective analysis of activity and haematological outcomes from the British Society of Blood and Marrow Transplantation and Cellular Therapy (BSBMTCT)

British Journal of Haematology, EarlyView.
We report the UK experience of autologous haematopoietic stem cell transplantation (AHSCT) for multiple sclerosis (MS) in 364 patients. In our observational study, transplant‐related mortality was 1.4%, Epstein–Barr virus reactivation occurred in 75.9%, while disability progression‐free survival was 83.5% at 2 years post‐AHSCT and 62.4% at 5 years.
Majid Kazmi, Paolo A. Muraro, Varun Mehra, Ian Gabriel, Eleonora De Matteis, Gavin Brittain, Alice Mariottini, Richard Nicholas, Eli Silber, Julia Lee, Rachel Pearce, Ruth Paul, Maria Pia Sormani, Alessio Signori, Victoria Potter, Eduardo Olavarria, Ram Malladi, Basil Sharrack, John A. Snowden   +18 more
wiley   +1 more source

Vaccination against Rabbit Hemorrhagic Disease Virus 2 (RHDV2) Using a Baculovirus Recombinant Vaccine Provides Durable Immunity in Rabbits

Viruses
Rabbit hemorrhagic disease virus 2 (RHDV2) emerged in the United States in 2018 and has spread in both domestic and wild rabbits nationwide. The virus has a high mortality rate and can spread rapidly once introduced in a rabbit population.
Angela M. Bosco-Lauth, Amber Schueler, Edward Midthun, Hailey Tyra, Amanda Held, Claire Hood, Marissa Quilici, Sara Erickson, Sherry Glover, Bradley Gustafson, Gary Anderson   +10 more
doaj   +1 more source

KYNA Ameliorates Hepatic Ischemia–Reperfusion Injury by Activating the Hippo Signalling Pathway via FTO‐Dependent m6A Demethylation of LATS1

Cell Proliferation, EarlyView.
Our study elucidates the cellular and molecular mechanisms underlying KYNA's protective effects against HIRI. It emphasises that KYNA modulates the methylation status of the Hippo signalling pathway through the activation of AHR, thereby mitigating damage by promoting LATS1 degradation and facilitating the nuclear translocation of YAP. ABSTRACT Hepatic
Wenjie Zheng, Xiaowen Wang, Haoqi Chen, Kaiming He, Xijing Yan, Yuan Zhang, Yang Yang, Peng Zhang, Wenfeng Zhu, Shuguang Zhu, Hua Li   +10 more
wiley   +1 more source

Recombinant Lactobacillus casei Expressing Capsid Protein VP60 can Serve as Vaccine Against Rabbit Hemorrhagic Disease Virus in Rabbits

Vaccines, 2019
Rabbit hemorrhagic disease virus (RHDV) is the causative agent of rabbit hemorrhagic disease (RHD). RHD, characterized by hemorrhaging, liver necrosis, and high morbidity and mortality in rabbits and hares, causes severe economic losses in the rabbit ...
Li Wang, Tian Xia, Tiantian Guo, Yi Ru, Yanping Jiang, Wen Cui, Han Zhou, Xinyuan Qiao, Lijie Tang, Yigang Xu, Yijing Li   +10 more
doaj   +1 more source

Rabbit Hemorrhagic Disease Virus in Mexico in 2020-2021: Risk Areas and Climatic Distribution. [PDF]

Viruses
Mexico is home to 14 species of lagomorphs, 6 of which are endemic. Studies on diseases affecting native lagomorphs are scarce, and in most cases, the impact on their populations remains largely unknown. Rabbit hemorrhagic disease virus (RHDV), especially the RHDV2 variant, causes a serious and extremely contagious disease, resulting in high mortality ...
Lorenzo C, Fernández JA, Hernández-Quiroz NS, Lafón Terrazas A, Tapia-Ramírez G.   +4 more
europepmc   +4 more sources

Fatal Elephant Endotheliotropic Herpesvirus Infection of Two Young Asian Elephants [PDF]

, 2019
Elephant endotheliotropic herpesvirus (EEHV) can cause a devastating haemorrhagic disease in young Asian elephants worldwide. Here, we report the death of two young Asian elephants after suffering from acute haemorrhagic disease due to EEHV-1A infection.
Andreotti, Sandro, Azab, Walid, Eschke, Kathrin, Flügger, Michael, Kaessmeyer, Sabine, Osterrieder, Nikolaus, Pavulraj, Selvaraj, Prahl, Adriane, Trimpert, Jakob, van den Doel, Petra B.   +9 more
core   +3 more sources

Managing Haemophilic Arthropathy in People With Haemophilia in Japan: An Informal Consensus

Haemophilia, EarlyView.
ABSTRACT Introduction People with haemophilia who develop haemophilic arthropathy experience disabling physical effects, limiting functionality and quality of life (QOL). Although Clinical Practice Guidelines are available for haemophilia management, consensus on haemophilic arthropathy management is needed.
Kumiko Ono, Azusa Nagao, Yusuke Inagaki, Kagehiro Amano, Miwa Goto, Makoto Kaneda, Kenichiro Makino, Chiai Nagae, Akihiro Sawada, Rie Shirayama, Nobuaki Suzuki, Masahiro Takeyama, Naoya Yamasaki, Hideyuki Takedani   +13 more
wiley   +1 more source

Genetic characterization of interleukins (IL-1α, IL-1β, IL-2, IL-4, IL-8, IL-10, IL-12A, IL-12B, IL-15 and IL-18) with relevant biological roles in lagomorphs [PDF]

, 2015
Disponível em: www.ncbi.nlm.nih.gov/pmc/articles/pmid/26395994/ILs, as essential innate immune modulators, are involved in an array of biological processes.
Abrantes, J., Almeida, T., Costa, Paulo, de Matos, A.L., Esteves, P.J., Neves, F.   +5 more
core   +1 more source

Overcoming species barriers: an outbreak of Lagovirus europaeus GI.2/RHDV2 in an isolated population of mountain hares (Lepus timidus)

BMC Veterinary Research, 2018
Background Prior to 2010, the lagoviruses that cause rabbit hemorrhagic disease (RHD) in European rabbits (Oryctolagus cuniculus) and European brown hare syndrome (EBHS) in hares (Lepus spp.) were generally genus-specific.
Aleksija S. Neimanis, Harri Ahola, Ulrika Larsson Pettersson, Ana M. Lopes, Joana Abrantes, Siamak Zohari, Pedro J. Esteves, Dolores Gavier-Widén   +7 more
doaj   +1 more source