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Early Pathogenesis in Rabbit Hemorrhagic Disease Virus 2
SSRN Electronic Journal, 2022To detail early tissue distribution and innate immune response to rabbit hemorrhagic disease virus 2 (RHDV2), 13 rabbits were orally (Oryctolagus cuniculus) inoculated with liver homogenate made from a feral rabbit that succumbed to RHDV2 during the 2020 outbreak in Oregon, USA.
Alicia D. O'Toole +3 more
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Structural Basis for Rabbit Hemorrhagic Disease Virus Antibody Specificity
Journal of Virology, 2022Isolated RHDV antibodies have been used for decades to distinguish between antigenic variants, monitor temporal capsid evolution, and examine neutralizing capacities. In this study, we provided the structural basis for an RHDV GI.2 specific diagnostic antibody (2D9) binding and reveal that a small number of amino acid substitutions at the binding site ...
Mila M. Leuthold +6 more
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Down the Rabbit Hole: Domestic Rabbit Owners’ Perceptions of Rabbit Hemorrhagic Disease Virus 2
EcoHealth, 2022Rabbit hemorrhagic disease virus 2 (RHDV2) is a highly contagious pathogen that infects wild and domestic rabbits and hares (lagomorphs). Globally, RHDV2 has resulted in substantial economic losses for commercial rabbit trade and caused wild lagomorph population declines.
Hannah G. Shapiro +2 more
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Characterization of rabbit hemorrhagic disease virus field isolates in Taiwan
Journal of Virological Methods, 1998Liver tissues from animals that were suspected to have died of rabbit hemorrhagic disease (RHD) were used for isolation and characterization of the causative agent. Three strains of RHD virus were isolated as the supernatants of liver homogenates reacted positively by hemagglutination (HA) assays and were infective for rabbits after second passage in ...
Jui Hung Shien +2 more
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Serologic comparison of four isolates of rabbit hemorrhagic disease virus
Veterinary Microbiology, 1995An acute, fatal disease of rabbits, termed Rabbit Hemorrhagic Disease (RHD), has occurred in Asia, Europe, and North America since 1984. The clinical signs, pathologic lesions, and epidemiologic features seen in the various outbreaks were very similar.
Carol House, Mary Lou Berninger
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Assessment of a Novel Vaccine Against Rabbit Hemorrhagic Disease Virus in Young Rabbits
Viral Immunology, 2016Rabbit hemorrhagic disease virus (RHDVb) is the new variant of the classical RHDV, a virulent pathogen responsible for an acute disease in young rabbits. The virus invades internal organs, especially the liver, spleen, kidneys, and gut; prevents coagulation; and causes liver necrosis.
Javier Fuentes Merino +3 more
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Sequence and genomic organization of a rabbit hemorrhagic disease virus isolated from a wild rabbit
Virus Genes, 1995Rabbit hemorrhagic disease virus (RHDV) is a member of the caliciviridae family. The nucleotidic sequence of a full-length cDNA of one RHDV isolate (RHDV-SD) is reported. The genome is 7437 bases long and includes two ORFs, ORF1 (7034 b) and ORF2 (353 b), coding for the polyprotein and the Vp12, respectively.
Rasschaert, Denis +3 more
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Emergence of new virulent rabbit hemorrhagic disease virus strains in Saudi Arabia [PDF]
Tropical Animal Health and Production, 2016 Rabbit hemorrhagic disease is an acute fatal highly contagious viral infectious disease that causes high losses among rabbitries. The disease was first reported in China in 1984 and later on in Saudi Arabia in 1996. The aim of this study was to investigate the emergence and pathogenicity of new rabbit hemorrhagic disease virus (RHDV) strains in Saudi ...
Mohamed Al-Hammadi +3 more
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Vaccine, 1997
An ALVAC (canarypox)-based recombinant virus ALVAC-RHDV (vCP309) expressing a native rabbit hemorrhagic disease virus (RHDV) capsid protein was derived and assessed for its protective efficacy in rabbits. Protection against a lethal RHDV challenge was demonstrated in rabbits inoculated twice with either high (10(7) p.f.u.) or low (10(5) p.f.u.) doses ...
E. Paoletti +3 more
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An ALVAC (canarypox)-based recombinant virus ALVAC-RHDV (vCP309) expressing a native rabbit hemorrhagic disease virus (RHDV) capsid protein was derived and assessed for its protective efficacy in rabbits. Protection against a lethal RHDV challenge was demonstrated in rabbits inoculated twice with either high (10(7) p.f.u.) or low (10(5) p.f.u.) doses ...
E. Paoletti +3 more
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Virus Research, 1995
A panel of anti-rabbit hemorrhagic disease virus (anti-RHDV) monoclonal antibodies was produced and characterized. The ability of the MAbs to recognize epitopes present on RHDV capsids, European brown hare syndrome virus capsids and RHDV subunits was determined.
Giulia Frigoli +5 more
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A panel of anti-rabbit hemorrhagic disease virus (anti-RHDV) monoclonal antibodies was produced and characterized. The ability of the MAbs to recognize epitopes present on RHDV capsids, European brown hare syndrome virus capsids and RHDV subunits was determined.
Giulia Frigoli +5 more
openaire +3 more sources