Results 81 to 90 of about 349,819 (308)

Is diabetes a risk factor for a severe clinical presentation of dengue? Review and meta-analysis [PDF]

, 2015
BACKGROUND: The mean age of acute dengue has undergone a shift towards older ages. This fact points towards the relevance of assessing the influence of age-related comorbidities, such as diabetes, on the clinical presentation of dengue episodes ...
Valérie D'Acremont, Eze, I. C., Probst-Hensch, N., Eze, I.C., Nan Shwe Nwe Htun, Ikenna C. Eze (729620), Odermatt, P., Ikenna C Eze, Htun, N.S., Boillat-Blanco, N., Htun, N. S., Nicole Probst-Hensch (520032), Peter Odermatt, Peter Odermatt (148926), D'Acremont, V., Nicole Probst-Hensch, Noémie Boillat-Blanco (729621), Valérie D’Acremont (729622), Nan Shwe Nwe Htun (729619), Noémie Boillat-Blanco   +19 more
core   +1 more source

The genetic architecture of epilepsy across molecular mechanisms and clinical heterogeneity

Epilepsia Open, EarlyView.
Abstract Epilepsy comprises a highly heterogeneous group of neurological disorders unified by a persistent predisposition to recurrent seizures, yet driven by remarkably diverse genetic, molecular, and network‐level mechanisms. Advances in genomic technologies have revealed that epilepsy arises from a multilayered genetic architecture encompassing rare
Mohammad Reza Seyedtaghia, Jina Babanzadeh, Marcello Scala, Lorenzo Perilli, Pasquale Striano   +4 more
wiley   +1 more source

Astrocyte subtype‐specific alterations in the dentate gyrus of individuals with mesial temporal lobe epilepsy

Epilepsia Open, EarlyView.
Abstract Objective Epilepsy affects approximately 50 million people worldwide and, although primarily attributed to neuronal dysfunction, increasing evidence highlights a critical role of glial cells, particularly astrocytes, in the pathophysiological mechanisms.
Chiara Lötzsch, Jakob Johann Schmidt, Daniel Delev, Roland Coras, Ingmar Blümcke, Ruth Beckervordersandforth   +5 more
wiley   +1 more source

Generation and characterization of a recombinant Rift Valley fever virus expressing a V5 epitope-tagged RNA-dependent RNA polymerase [PDF]

, 2011
The viral RNA-dependent RNA polymerase (RdRp; L protein) of Rift Valley fever virus (RVFV; family Bunyaviridae) is a 238 kDa protein that is crucial for the life cycle of the virus, as it catalyses both transcription of viral mRNAs and replication of the
Brennan, Benjamin, Richard M. Elliott, Li, Ping, Ping Li, Elliott, Richard M., Benjamin Brennan   +5 more
core   +1 more source

Cheek tooth extraction in geriatric versus non‐geriatric horses

Equine Veterinary Journal, EarlyView.
Abstract Background Age‐related dental changes are major contributors to dental disorders in older horses, and cheek tooth extractions are often required to maintain masticatory function and oral comfort. However, limited information is available on clinical and treatment characteristics in this older patient population.
Elias Mair, Omid Nekouei, Patricia Trummer‐Schug, Rhea Haralambus, Nora Mareike Biermann   +4 more
wiley   +1 more source

Recent advances in understanding dengue [version 1; referees: 3 approved]

F1000Research, 2016
Dengue is an emerging threat to billions of people worldwide. In the last 20 years, the incidence has increased four-fold and this trend appears to be continuing.
Sophie Yacoub, Juthathip Mongkolsapaya, Gavin Screaton   +2 more
doaj   +1 more source

Diagnostic Assays for Crimean-Congo hemorrhagic fever [PDF]

, 2012
Crimean-Congo hemorrhagic fever (CCHF) is a highly contagious viral tick-borne disease with case-fatality rates as high as 50%. We describe a collaborative evaluation of the characteristics, performance, and on-site applicability of serologic and ...
Miša Korva, Sidira, P., Maria João Alves, Sharifi-Mood, Batool, Helen Karlberg, Korukluoğlu, Gülay, Chinikar, S., Zupanc, T.A., Mirazimi, A., Jessica Vanhomwegen, Philippe Dubois, Wolfel, R., Wölfel, Roman, Bino, Silvia, Mousavi, Mehrdad, Tatjana Avšič Županc, Katerina Tsergouli, Saksida, A., Gülay Korukluoğlu, Tsergouli, K., Mardani, Masoud, Silvia Bino, Chinikar, Sadegh, Roman Wölfel, Sidira, Persofoni, Vanhomwegen, J., Korukluoglu, G., Alves, M.J., Dubois, Philippe, Zeller, Hervé, Masoud Mardani, Saksida, Ana, Mirazimi, Ali, Hervé Zeller, Karlberg, H., Tsergouli, Katerina, Ali Mirazimi, Ana Saksida, Sharifi-Mood, B., Dubois, P., Anna Papa, Alves, Maria João, Papa, A., Mehrdad Mousavi, Vanhomwegen, Jessica, Persofoni Sidira, Mousavi, M., Papa, Anna, Mardani, M., Sadegh Chinikar, Korva, M., Karlberg, Helen, Bino, S., Batool Sharifi-Mood, Zeller, H., Korva, Miša, Županc, Tatjana Avšič   +56 more
core   +1 more source

Engineering mRNA‐LNP Medicines for the Ageing Brain: Opportunities and Challenges for Neurodegenerative Diseases

Exploration, EarlyView.
This review highlights recent advances in engineering messenger RNA (mRNA)‐lipid nanoparticles (LNPs) to cross the ageing blood–brain barrier and target neurodegenerative diseases. It outlines design principles, delivery routes, and translational challenges, charting a roadmap towards clinical application of mRNA‐LNP therapeutics for neurodegenerative ...
Abdel Ali Belaidi, Denzil L. Furtado, Francesca Alves, Rebecca M. Nisbet, Scott Ayton, Ashley I. Bush   +5 more
wiley   +1 more source

Filovirus Hemorrhagic Fever Outbreak Case Management: A Review of Current and Future Treatment Options [PDF]

, 2011
: Testing an innovative therapy for filovirus hemorrhagic fever (FHF) in an outbreak setting may be years away. Moreover, beyond anecdotal evidence, little is known about best practice for outbreak case management.
Borchert, M., Roddy, Paul, Jeffs, B., Robert Colebunders, Benjamin Jeffs, van Herp, Michel, Van Herp, M., Pedro Pablo Palma, Roddy, P., Jeffs, Benjamin, Colebunders, Robert, Matthias Borchert, Paul Roddy, Palma, P. P., Borchert, Matthias, Colebunders, R., Michel Van Herp, Palma, Pedro Pablo   +17 more
core   +1 more source

Identifying Avoidable Emergency Department Visits and the Potential Role of Community Health Centers in Northern Italy: A Retrospective Observational Study

Health Care Science, EarlyView.
Using data from an Italian emergency department (ED), ED visits preventable through integrated community care models (community health centers) were identified. ED visits were classified based on presenting symptoms, comorbidities, medication use, and age.
Silvia Caristia, Isabella Santomauro, Erika Bassi, Laura Ferraris, Alberto Dal Molin, Fabrizio Faggiano   +5 more
wiley   +1 more source