Results 91 to 100 of about 70,208 (264)

Does electrocardiography at admission predict outcome in Crimean-Congo hemorrhagic fever [PDF]

Journal of Vector Borne Diseases, 2011
Background & objectives: Crimean-Congo hemorrhagic fever is an acute viral hemorrhagic fever withconsiderable mortality. Despite increasing knowledge about hemorrhagic fever viruses, the pathogenesis ofCrimean-Congo hemorrhagic fever and causes of death ...
Mehmet Birhan Yilmaz , Aynur Engin , Gokhan Bektasoglu , Ali Zorlu , Meltem Refiker EGE , Mehmet Bakir & Ilyas Dokmetas
doaj  

A multiplex interactome of Ebola virus proteins reveals TM9SF2 as a cell‐surface attachment factor that promotes viral entry

iMetaOmics, EarlyView.
This study generates a comprehensive Ebola virus (EBOV)‐human protein–protein interactome, comprising 1728 core high‐confidence interactions. Further interactome analysis revealed the potential association of EBOV glycoprotein (GP) with the host factor TM9SF2. Subsequent mechanistic investigations confirmed that TM9SF2 functions as an attachment factor
Limin Shang, Shouwen Du, Yuchen Liu, Letian Li, Xi Wu, Yanzhi Yuan, Chaozhi Jin, Qingkun Mi, Yuhang Wang, Xiaoshuang Shi, Jiamin Wang, Guoqing Zhang, Yidan Ma, Weijin Huang, Jigang Wang, Jian Wang, Chang Li   +16 more
wiley   +1 more source

Spatio-temporal spread of Lassa virus and a new rodent host in the Mano River Union area, West Africa

Emerging Microbes and Infections
The spread of Lassa virus (LASV) in Guinea, Liberia and Sierra Leone, which together are named the Mano River Union (MRU) area, was examined phylogeographically.
Umaru Bangura, Christopher Davis, Joyce Lamin, James Bangura, Barré Soropogui, Andrew J. Davison, Jenna Nichols, Matej Vucak, Mickael Dawson, Rashid Ansumana, Dianah Sondufu, Dániel Cadar, Toni Rieger, Emma Thomson, Foday Sahr, N’Faly Magassouba, Bruno Ghersi, Brian H. Bird, Elisabeth Fichet-Calvet   +18 more
doaj   +1 more source

Single‐Cell Profiling Identifies CLEC5A+ Macrophages as Key Drivers of Thoracic Aortic Aneurysm Via CCL5‐Mediated M1 Polarization

Journal of Clinical Laboratory Analysis, EarlyView.
Thoracic aortic aneurysm (TAA) is a life‐threatening cardiovascular disease with limited therapeutic options. Through single‐cell RNA sequencing of aortic tissues from healthy individuals and TAA patients (105,541 cells), we identified CLEC5A+macrophages as the predominant pathogenic cell population exhibiting the highest M1 polarization score. Machine
Xiangyu Li, Chunguang Guo, Mingyao Luo, Chang Shu   +3 more
wiley   +1 more source

A Comprehensive Study of Bidirectional Interactions Between the Human Microbiome and Blood Malignancies and Hematologic Conditions: Focus on Novel Therapeutic Strategies

Journal of Clinical Laboratory Analysis, EarlyView.
Microbiota‐targeted therapeutic strategies in hematological disorders. aHSCT: Transplanted immune cells from the donor may attack the recipient's tissues, especially when damage to the intestinal epithelium disrupts the gut microbiota, contributing to GVHD. Maintaining a balanced gut microbiota that supports immune regulation helps reduce GVHD risk and
Alireza Molajafari, Hadi Sedigh Ebrahim‐Saraie, Majid Taati Moghadam, Meysam Hasannejad‐Bibalan   +3 more
wiley   +1 more source

A Practical and Efficient Multiplex qPCR Assay for Simultaneous Detection of HLA Cross‐Reactive Groups and Human Platelet Antigens

Journal of Clinical Laboratory Analysis, EarlyView.
This assay enables multiplex genotyping of HLA‐CREGs and HPA alleles from whole blood using qPCR with an integrated parallel negative control. Results are interpreted based on amplification curves and Ct values, with validity dependent on strict quality control criteria for both the target reactions and the negative control.
Huimin Ji, Kaihao Feng, Yunping Xu, Le Chang, Ying Yan, Jie Ma, Yi Liu, Jinfeng Zeng, Huizhen Sun, Lunan Wang   +9 more
wiley   +1 more source

Domperidone inhibits dengue virus infection by targeting the viral envelope protein and nonstructural protein 1

Scientific Reports
Dengue is a mosquito-borne disease caused by dengue virus (DENV) infection, which remains a major public health concern worldwide owing to the lack of specific treatments or antiviral drugs available.
Nuttapong Kaewjiw, Thanawat Thaingtamtanha, Damini Mehra, Wanida Chawnawa, Tanapan Prommool, Chunya Puttikhunt, Adisak Songjaeng, Kessiri Kongmanas, Panisadee Avirutnan, Prasit Luangaram, Chatchawan Srisawat, Sittiruk Roytrakul, Stephan A. Bäurle, Sansanee Noisakran   +13 more
doaj   +1 more source

Development and External Validation of Logistic Regression Models Integrating Conventional Complete Blood Count and Cell Population Data for Predicting RT‐PCR–Confirmed Dengue

Journal of Clinical Laboratory Analysis, EarlyView.
We developed logistic regression models integrating routine complete blood count (CBC) parameters and analyzer‐derived cell population data (CPD) to predict RT‐PCR–confirmed dengue infection and evaluated their performance across internal and external settings.
Lin‐Chen Hsu, Yu‐Ching Weng, Wen‐Chun Liu   +2 more
wiley   +1 more source

Diagnostic Performance of Ultrasound in Adult Appendicitis. A Retrospective Review of 331 Cases

Journal of Medical Radiation Sciences, EarlyView.
The sensitivity of ultrasound in the detection of appendicitis had a prevalence of 16% in our predominantly young female cohort, with alternative gynaecological and abdominal diagnoses identified approximately 2:1. The sensitivity for ultrasound to detect appendicitis was 60%, with specificity of 98% and negative predictive value (NPV) of 93%.
Alistair Lock, Martin Necas
wiley   +1 more source

Myeloid sarcoma presenting as an isolated pancreatic mass in a 3‐year‐old child

JPGN Reports, EarlyView.
Abstract Myeloid sarcoma (MS) is an extramedullary tumor of myeloid precursor cells, frequently associated with acute myeloid leukemia (AML), and rarely occurring in isolation. We present a child with obstructive jaundice secondary to a pancreatic head mass.
Jappmann Kaur Monga, Cara L. Mack, Michelle Saad, Dylan Applin, Maisam Abu‐El‐Haija, David Vitale, Zachary Graff, Gila Ginzburg   +7 more
wiley   +1 more source