Results 81 to 90 of about 2,606 (185)

Dissecting Henipavirus W proteins conformational and fibrillation properties: contribution of their N‐ and C‐terminal constituent domains

The FEBS Journal, Volume 292, Issue 3, Page 556-581, February 2025.
The W proteins of Nipah and Hendra viruses exhibit fibrillation abilities in vitro, which have been attributed to the intrinsically disordered N‐terminal domain (NTD). Our research shows that the C‐terminal domain (CTD) of both viruses is intrinsically disordered and non‐fibrillogenic.
Giulia Pesce, Frank Gondelaud, Denis Ptchelkine, Christophe Bignon, Patrick Fourquet, Sonia Longhi   +5 more
wiley   +1 more source

The Current Pathogenicity and Potential Risk Assessment of Nipah Virus as Potential Cause of “Disease X”: A Narrative Review

Health Science Reports, Volume 7, Issue 12, December 2024.
ABSTRACT Background and Aims The World Health Organization (WHO) recognized the potential for a severe international epidemic and introduced the term “Disease X” to classify pathogens that not yet identified. The Nipah virus (NiV) is highly dangerous due to its zoonotic nature, high mortality rate, and ability to cause severe clinical symptoms in ...
Samiha Mehnaz, Ramisa Anjum, Fatema Rahman Mithila, Syed Masudur Rahman Dewan, Md. Rabiul Islam   +4 more
wiley   +1 more source

The YPLGVG sequence of the Nipah virus matrix protein is required for budding [PDF]

, 2008
Background Nipah virus (NiV) is a recently emerged paramyxovirus capable of causing fatal disease in a broad range of mammalian hosts, including humans.
Yan Lianying, McCarthy Sarah E, Han Ziying, Patch Jared R, Wang Lin-Fa, Harty Ronald N, Broder Christopher C   +6 more
core   +2 more sources

Each flying fox on its own branch:a phylogenetic tree for Pteropus and related genera (Chiroptera: Pteropodidae) [PDF]

, 2014
Pteropodidae is a diverse Old World family of non-echolocating, frugivorous and nectarivorous bats that includes the flying foxes (genus Pteropus) and allied genera. The subfamily Pteropodinae includes the largest living bats and is distributed across an
Cunha Almeida, Francisca, Giannini, Norberto Pedro, Helgen, Kristofer M., Simmons, Nancy B.   +3 more
core   +2 more sources

Serological Evidence for Henipa-like and Filo-like Viruses in Trinidad Bats. [PDF]

, 2020
Bat-borne zoonotic pathogens belonging to the family Paramxyoviridae, including Nipah and Hendra viruses, and the family Filoviridae, including Ebola and Marburg viruses, can cause severe disease and high mortality rates on spillover into human ...
Anthony, Simon, Avanzato, Victoria, Broder, Christopher, Carrington, Christine, Epstein, Jonathan, Fischer, Robert, Foster, Jerome, Goldstein, Tracey, Laing, Eric, Letko, Michael, Matson, M, Munster, Vincent, Ramkissoon, Vernie, Schountz, Tony, Schulz, Jonathan, Seetahal, Janine, Seifert, Stephanie, Sterling, Spencer, Thompson, John, Tremeau-Bravard, Alexandre, Yan, Lianying   +20 more
core   +1 more source

The Unique Immune System of Bats: An Evolutionary Analysis and Bibliometric Study

Ecology and Evolution, Volume 14, Issue 11, November 2024.
Through the evolutionary and bibliometric analyses, this study identified several critical immune genes and signaling pathways related to bat immunity. Currently, research on the immune system of bats primarily focuses on the themes of “efficient antiviral responses” and “inflammation suppression.” ABSTRACT Bats exhibit a greater capacity to tolerate ...
Rui Li, Wenliang Zhao, Apeng Chen, Zhiqiang Wu, Gejing De   +4 more
wiley   +1 more source

Quantifying Global Drivers of Zoonotic Bat Viruses: A Process-based Perspective [PDF]

, 2015
Emerging infectious diseases (EIDs), particularly zoonoses, represent a significant threat to global health. Emergence is often driven by anthropogenic activity (e.g. travel, land use change).
Brierley, L, Daszak, P, Jones, KE, Olival, KJ, Vonhof, M   +4 more
core   +1 more source

Evidence of exposure to henipaviruses in domestic pigs in Uganda [PDF]

Transboundary and Emerging Diseases, 2019
(Uploaded by Plazi for the Bat Literature Project) Hendra virus (HeV) and Nipah virus (NiV), belonging to the genus Henipavirus, are among the most pathogenic of viruses in humans. Old World fruit bats (family Pteropodidae) are the natural reservoir hosts.
Christine Atherstone, Sandra Diederich, Hana M. Weingartl, Kerstin Fischer, Anne Balkema‐Buschmann, Delia Grace, Silvia Alonso, Navneet K. Dhand, Michael P. Ward, Siobhan M. Mor   +9 more
openaire   +3 more sources

Current progress towards prevention of Nipah and Hendra disease in humans: A scoping review of vaccine and monoclonal antibody candidates being evaluated in clinical trials

Tropical Medicine &International Health, Volume 29, Issue 5, Page 354-364, May 2024.
Abstract Objectives Nipah and Hendra are deadly zoonotic diseases with pandemic potential. To date, no human vaccine or monoclonal antibody (mAb) has been licensed to prevent disease caused by these pathogens. The aim of this scoping review was to identify and describe all Phase I, II, and III clinical trials of vaccine candidates or mAbs candidates ...
Valerie Rodrigue, Katie Gravagna, Jacqueline Yao, Vaidehi Nafade, Nicole E. Basta   +4 more
wiley   +1 more source

Structural basis for antibody recognition of vulnerable epitopes on Nipah virus F protein

Nature Communications, 2023
Henipaviruses such as Nipah virus (NiV) cause severe encephalitis with high fatality rates in humans. NiV fusion (F) glycoprotein is a key target of the host immune response. Here, Byrne et al.
Patrick O. Byrne, Brian E. Fisher, David R. Ambrozak, Elizabeth G. Blade, Yaroslav Tsybovsky, Barney S. Graham, Jason S. McLellan, Rebecca J. Loomis   +7 more
doaj   +1 more source