Discovery of a Rodent Hepacivirus in the Brazilian Amazon [PDF]
VirusesIn the eastern Brazilian Amazon, the Viseu municipality has almost 70% of its territory deforested. Monitoring viruses from wildlife hosts enables the prevention and control of epizootic events and outbreaks.
Nelielma G. Oliveira Prestes +11 more
doaj +5 more sources
CD4+ T cell help during early acute hepacivirus infection is critical for viral clearance and the generation of a liver-homing CD103+CD49a+ effector CD8+ T cell subset. [PDF]
PLoS PathogensIn hepatitis C virus (HCV) infection, CD4+ and CD8+ T cells are crucial for viral control. However, a detailed understanding of the kinetic of CD4+ T cell help and its role in the generation of different CD8+ T cell subsets during acute infection is ...
Jarrett Lopez-Scarim +3 more
doaj +4 more sources
A novel genotype of Hepacivirus bovis identified in reindeer (Rangifer tarandus) in northeastern China [PDF]
Frontiers in Cellular and Infection MicrobiologyBackgroundHepaciviruses (family Flaviviridae) are significant pathogens affecting both human and animal health. While the hepatitis C virus (Hepacivirus hominis) is extensively studies in humans, related viruses have been identified across various animal
Wenbo Xu +6 more
doaj +5 more sources
Identification and epidemiology of a novel Hepacivirus in domestic ducks in Hunan province, China [PDF]
Frontiers in Veterinary ScienceThe genus Hepacivirus comprises a diverse range of genetically distinct viruses that infect both mammalian and non-mammalian hosts, with some posing significant risks to human and animal health.
Jin-Tao Chen +4 more
doaj +4 more sources
Identification of a Novel Hepacivirus in Southeast Asian Shrew (Crocidura fuliginosa) from Yunnan Province, China [PDF]
Pathogens, 2023 The genus Hepacivirus contains single-stranded positive-sense RNA viruses belonging to the family Flaviviridae, which comprises 14 species. These 14 hepaciviruses have been found in different mammals, such as primates, dogs, bats, and rodents.
Ling Guo +10 more
doaj +5 more sources
An Equine Model for Vaccination against a Hepacivirus: Insights into Host Responses to E2 Recombinant Protein Vaccination and Subsequent Equine Hepacivirus Inoculation [PDF]
Viruses, 2022 Equine hepacivirus (EqHV) is the closest known genetic homologue of hepatitis C virus. An effective prophylactic vaccine is currently not available for either of these hepaciviruses. The equine as potential surrogate model for hepacivirus vaccine studies
Marcha Badenhorst +21 more
doaj +6 more sources
Hepatic iNKT cells produce type 2 cytokines and restrain antiviral T cells during acute hepacivirus infection [PDF]
Frontiers in Immunology, 2022 Chronic hepatitis C virus (HCV) infection is a curable disease, but the absence of a vaccine remains a major problem in infection prevention. The lack of small animal models and limited access to human liver tissue impede the study of hepatic antiviral ...
Svjetlana Raus +3 more
doaj +3 more sources
Molecular Determinants of Mouse Adaptation of Rat Hepacivirus [PDF]
Journal of Virology, 2023 A prophylactic vaccine is required to achieve the World Health Organization’s objective for hepatitis C virus elimination as a serious public health threat.
Raphael Wolfisberg +11 more
semanticscholar +5 more sources
The Detection and Phylogenetic Analysis of Bovine Hepacivirus in China [PDF]
BioMed Research International, 2018 Hepacivirus has been identified in cattle in Africa, Europe, and South America. In this survey of bovine hepacivirus (BovHepV) in 131 serum samples from Chinese cattle herds using RT-PCR, five of 131 sera were BovHepV positive, with the infection rate of
Deng, Yu +4 more
core +8 more sources
Description of an Equine Hepacivirus Cluster in a Horse Stable in Italy [PDF]
Transboundary and Emerging Diseases, 2023 Equine hepacivirus (EqHV), also known as Hepacivirus A, represents the most closely related genetic homologue of human hepatitis C virus (HCV). Although detected worldwide, limited information on the clinical features of this infection is available and ...
Robert A. Cardone +9 more
semanticscholar +5 more sources