Results 11 to 20 of about 44,284 (201)

First identification of bovine hepacivirus in wild boars

Scientific Reports, 2022
Hepatitis C virus (HCV) is a major cause of chronic hepatitis, cirrhosis and hepatocellular carcinoma in humans. Humans were long considered the only hosts of Hepacivirus.
Claudio de Martinis, Lorena Cardillo, Claudia Esposito, Maurizio Viscardi, Lorella Barca, Stefania Cavallo, Nicola D’Alessio, Vito Martella, Giovanna Fusco   +8 more
doaj   +3 more sources

A Novel Hepacivirus in Wild Rodents from South America [PDF]

Viruses, 2019
The Hepacivirus genus comprises single-stranded positive-sense RNA viruses within the family Flaviviridae. Several hepaciviruses have been identified in different mammals, including multiple rodent species in Africa, Asia, Europe, and North America.
William Marciel de Souza, Marcílio Jorge Fumagalli, Gilberto Sabino-Santos, Felipe Gonçalves Motta Maia, Sejal Modha, Márcio Roberto Teixeira Nunes, Pablo Ramiro Murcia, Luiz Tadeu Moraes Figueiredo   +7 more
doaj   +4 more sources

An Equine Model for Vaccination against a Hepacivirus: Insights into Host Responses to E2 Recombinant Protein Vaccination and Subsequent Equine Hepacivirus Inoculation

Viruses, 2022
Equine hepacivirus (EqHV) is the closest known genetic homologue of hepatitis C virus. An effective prophylactic vaccine is currently not available for either of these hepaciviruses. The equine as potential surrogate model for hepacivirus vaccine studies
Marcha Badenhorst, Armin Saalmüller, Janet M. Daly, Reinhard Ertl, Maria Stadler, Christina Puff, Madeleine de le Roi, Wolfgang Baumgärtner, Michael Engelmann, Sabine Brandner, Hannah K. Junge, Barbara Pratscher, Asisa Volz, Bertrand Saunier, Thomas Krey, Johannes Wittmann, Steffen Heelemann, Julien Delarocque, Bettina Wagner, Daniel Todt, Eike Steinmann, Jessika-M. V. Cavalleri   +21 more
doaj   +6 more sources

The Bank Vole (Clethrionomys glareolus)—Small Animal Model for Hepacivirus Infection [PDF]

Viruses, 2021
Many people worldwide suffer from hepatitis C virus (HCV) infection, which is frequently persistent. The lack of efficient vaccines against HCV and the unavailability of or limited compliance with existing antiviral therapies is problematic for health ...
Susanne Röhrs, Lineke Begeman, Beate K. Straub, Mariana Boadella, Dennis Hanke, Kerstin Wernike, Stephan Drewes, Bernd Hoffmann, Markus Keller, Jan Felix Drexler, Christian Drosten, Dirk Höper, Thijs Kuiken, Rainer G. Ulrich, Martin Beer   +14 more
doaj   +5 more sources

The Detection and Phylogenetic Analysis of Bovine Hepacivirus in China [PDF]

BioMed Research International, 2018
Hepacivirus has been identified in cattle in Africa, Europe, and South America. In this survey of bovine hepacivirus (BovHepV) in 131 serum samples from Chinese cattle herds using RT-PCR, five of 131 sera were BovHepV positive, with the infection rate of
Deng, Yu, Guan, Su Hua, Hao, Guiying, Rasmussen, Thomas Bruun, Wang, Silu   +4 more
core   +6 more sources

Chronic hepatitis in horses with persistent equine hepacivirus infection. [PDF]

Equine Vet J
Abstract Background Equine hepacivirus (EqHV) is closely related to hepatitis C virus (HCV), which causes persistent infection and chronic hepatitis in people. Information on persistent EqHV infection and hepatitis is limited. Objectives To report 19 cases of chronic hepatitis and persistent EqHV infection.
Jager MC, Luethy D, Shallop S, Cathcart J, Divers TJ, Tan JY, Beasley EM, Johnson P, Leduc L, Smith C, Jamieson CA, Magdesian KG, Van de Walle GR, Tomlinson JE.   +13 more
europepmc   +2 more sources

First Detection and Phylogenetic Analysis of Equine Hepacivirus (EqHV) in Iran. [PDF]

Vet Med Sci
This study presents the first detection of Hepacivirus equi (EqHV) in the equine population of Khuzestan Province, Iran. Molecular analysis revealed a prevalence rate of 4.66%, while phylogenetic analysis confirmed that the strain IR1‐Ahvaz‐2024 belongs to EqHV subtype 1.
Pourmahdi Borujeni M, Ghobadian Diali H, Mashhadi AG, Aliabad MJ.   +3 more
europepmc   +2 more sources

A Novel Subtype of Bovine Hepacivirus Identified in Ticks Reveals the Genetic Diversity and Evolution of Bovine Hepacivirus [PDF]

Viruses, 2021
Hepaciviruses represent a group of viruses that pose a significant threat to the health of humans and animals. New members of the genus Hepacivirus in the family Flaviviridae have recently been identified in a wide variety of host species worldwide. Similar to the Hepatitis C virus (HCV), bovine hepacivirus (BovHepV) is hepatotropic and causes acute or
Jian-Wei Shao, Luan-Ying Guo, Yao-Xian Yuan, Jun Ma, Ji-Ming Chen, Quan Liu   +5 more
openaire   +4 more sources

Novel bovine hepacivirus in dairy cattle, China [PDF]

Emerging Microbes & Infections, 2018
Since it was first identified in 1989, Hepatitis C virus (HCV) has long been regarded as having one true natural host—humans1.
Lu, Gang, Jia, Kun, Ping, Xiaokun, Huang, Ji, Luo, Aijian, Wu, Peixin, Li, Shoujun   +6 more
openaire   +2 more sources

Immune protection against reinfection with nonprimate hepacivirus [PDF]

Proceedings of the National Academy of Sciences, 2017
Significance Hepatitis C virus (HCV) displays a narrow species tropism severely hampering development of small animal models that are required for vaccine and pathogenesis studies in vivo. The recent discoveries of HCV-related hepaciviruses in diverse hosts offer new opportunities with respect to the development of an immunocompetent animal ...
Pfaender, Stephanie, Walter, Stephanie, Grabski, Elena, Todt, Daniel, Bruening, Janina, Romero-Brey, Inés, Gather, Theresa, Brown, Richard J P, Hahn, Kerstin, Puff, Christina, Pfankuche, Vanessa M, Hansmann, Florian, Postel, Alexander, Becher, Paul, Thiel, Volker, Kalinke, Ulrich, Wagner, Bettina, Bartenschlager, Ralf, Baumgärtner, Wolfgang, Feige, Karsten, Pietschmann, Thomas, Cavalleri, Jessika M V, Steinmann, Eike   +22 more
openaire   +3 more sources