Results 11 to 20 of about 41,094 (191)

Discovery of a Rodent Hepacivirus in the Brazilian Amazon [PDF]

Viruses
In the eastern Brazilian Amazon, the Viseu municipality has almost 70% of its territory deforested. Monitoring viruses from wildlife hosts enables the prevention and control of epizootic events and outbreaks.
Nelielma G. Oliveira Prestes, Leonardo H. Almeida Hernández, Fábio Silva da Silva, Thito Y. Bezerra da Paz, Andressa O. Aragão, Bruno C. Veloso de Barros, Ricardo J. P. S. Guimarães, Rommel T. J. Ramos, Lívia Medeiros Neves Casseb, Sandro Patroca da Silva, Pedro Fernando da Costa Vasconcelos, Ana Cecília Ribeiro Cruz   +11 more
doaj   +3 more sources

An Equine Model for Vaccination against a Hepacivirus: Insights into Host Responses to E2 Recombinant Protein Vaccination and Subsequent Equine Hepacivirus Inoculation [PDF]

Viruses, 2022
Equine hepacivirus (EqHV) is the closest known genetic homologue of hepatitis C virus. An effective prophylactic vaccine is currently not available for either of these hepaciviruses. The equine as potential surrogate model for hepacivirus vaccine studies
Marcha Badenhorst, Armin Saalmüller, Janet M. Daly, Reinhard Ertl, Maria Stadler, Christina Puff, Madeleine de le Roi, Wolfgang Baumgärtner, Michael Engelmann, Sabine Brandner, Hannah K. Junge, Barbara Pratscher, Asisa Volz, Bertrand Saunier, Thomas Krey, Johannes Wittmann, Steffen Heelemann, Julien Delarocque, Bettina Wagner, Daniel Todt, Eike Steinmann, Jessika-M. V. Cavalleri   +21 more
doaj   +7 more sources

A Highly Divergent Hepacivirus Identified in Domestic Ducks Further Reveals the Genetic Diversity of Hepaciviruses [PDF]

Viruses, 2022
Hepaciviruses represent a group of viruses that pose a significant threat to the health of humans and animals. During the last decade, new members of the genus Hepacivirus have been identified in various host species worldwide, indicating the widespread ...
Xue-Lian Zhang, Xin-Yan Yao, Yu-Qian Zhang, Zhi-Hang Lv, Hong Liu, Jing Sun, Jian-Wei Shao   +6 more
doaj   +2 more sources

A novel genotype of Hepacivirus bovis identified in reindeer (Rangifer tarandus) in northeastern China [PDF]

Frontiers in Cellular and Infection Microbiology
BackgroundHepaciviruses (family Flaviviridae) are significant pathogens affecting both human and animal health. While the hepatitis C virus (Hepacivirus hominis) is extensively studies in humans, related viruses have been identified across various animal
Wenbo Xu, Wei Wang, Liyan Sui, Nan Liu, Yinghua Zhao, Quan Liu, Quan Liu   +6 more
doaj   +2 more sources

First identification of bovine hepacivirus in wild boars

Scientific Reports, 2022
Hepatitis C virus (HCV) is a major cause of chronic hepatitis, cirrhosis and hepatocellular carcinoma in humans. Humans were long considered the only hosts of Hepacivirus.
Claudio de Martinis, Lorena Cardillo, Claudia Esposito, Maurizio Viscardi, Lorella Barca, Stefania Cavallo, Nicola D’Alessio, Vito Martella, Giovanna Fusco   +8 more
doaj   +3 more sources

Identification of a Novel Hepacivirus in Southeast Asian Shrew (Crocidura fuliginosa) from Yunnan Province, China [PDF]

Pathogens, 2023
The genus Hepacivirus contains single-stranded positive-sense RNA viruses belonging to the family Flaviviridae, which comprises 14 species. These 14 hepaciviruses have been found in different mammals, such as primates, dogs, bats, and rodents.
Ling Guo, Bei Li, Peiyu Han, Na Dong, Yan Zhu, Fuli Li, Haorui Si, Zhengli Shi, Bo Wang, Xinglou Yang, Yunzhi Zhang   +10 more
doaj   +2 more sources

A Novel Hepacivirus in Wild Rodents from South America [PDF]

Viruses, 2019
The Hepacivirus genus comprises single-stranded positive-sense RNA viruses within the family Flaviviridae. Several hepaciviruses have been identified in different mammals, including multiple rodent species in Africa, Asia, Europe, and North America.
William Marciel de Souza, Marcílio Jorge Fumagalli, Gilberto Sabino-Santos, Felipe Gonçalves Motta Maia, Sejal Modha, Márcio Roberto Teixeira Nunes, Pablo Ramiro Murcia, Luiz Tadeu Moraes Figueiredo   +7 more
doaj   +4 more sources

Identification and epidemiology of a novel Hepacivirus in domestic ducks in Hunan province, China [PDF]

Frontiers in Veterinary Science
The genus Hepacivirus comprises a diverse range of genetically distinct viruses that infect both mammalian and non-mammalian hosts, with some posing significant risks to human and animal health.
Jin-Tao Chen, Kang-Jing Chen, Kang-Wei Wu, Shan-Hong Yi, Jian-Wei Shao   +4 more
doaj   +2 more sources

Dose-Dependent Hepacivirus Infection Reveals Linkage between Infectious Dose and Immune Response

Microbiology Spectrum, 2022
More than 70 million people worldwide are still infected with the hepatitis C virus 30 years after its discovery, underscoring the need for a vaccine. To develop an effective prophylactic vaccine, detailed knowledge of the correlates of protection and an
André Gömer, Julien Delarocque, Christina Puff, Maximilian K. Nocke, Birthe Reinecke, Wolfgang Baumgärtner, Jessika M. V. Cavalleri, Karsten Feige, Eike Steinmann, Daniel Todt   +9 more
doaj   +2 more sources

CD4+ T cell help during early acute hepacivirus infection is critical for viral clearance and the generation of a liver-homing CD103+CD49a+ effector CD8+ T cell subset. [PDF]

PLoS Pathogens
In hepatitis C virus (HCV) infection, CD4+ and CD8+ T cells are crucial for viral control. However, a detailed understanding of the kinetic of CD4+ T cell help and its role in the generation of different CD8+ T cell subsets during acute infection is ...
Jarrett Lopez-Scarim, Dustyn Mendoza, Shashank M Nambiar, Eva Billerbeck   +3 more
doaj   +2 more sources