Results 21 to 30 of about 42,842 (184)

The Bank Vole (Clethrionomys glareolus)—Small Animal Model for Hepacivirus Infection [PDF]

Viruses, 2021
Many people worldwide suffer from hepatitis C virus (HCV) infection, which is frequently persistent. The lack of efficient vaccines against HCV and the unavailability of or limited compliance with existing antiviral therapies is problematic for health ...
Susanne Röhrs, Lineke Begeman, Beate K. Straub, Mariana Boadella, Dennis Hanke, Kerstin Wernike, Stephan Drewes, Bernd Hoffmann, Markus Keller, Jan Felix Drexler, Christian Drosten, Dirk Höper, Thijs Kuiken, Rainer G. Ulrich, Martin Beer   +14 more
doaj   +2 more sources

Mouse models of acute and chronic hepacivirus infection [PDF]

Science, 2017
New York City rats provide a gift to virologists Despite the development of curative drugs for hepatitis C virus (HCV) infection, global eradication of HCV will likely require a prophylactic vaccine. Progress toward a vaccine has been impeded by the absence of mouse models suitable for studying the immune response
Eva Billerbeck, Raphael Wolfisberg, Ulrik Fahnøe, Jing W. Xiao, Corrine Quirk, Joseph M. Luna, John M. Cullen, Alex S. Hartlage, Luis Chiriboga, Kalpana Ghoshal, W. Ian Lipkin, Jens Bukh, Troels K. H. Scheel, Amit Kapoor, Charles M. Rice   +14 more
openaire   +4 more sources

Acute and chronic infections with nonprimate hepacivirus in young horses [PDF]

Veterinary Research, 2016
The recently discovered nonprimate hepacivirus (NPHV) naturally infects horses and is the closest known homolog of hepatitis C virus to date. Within a follow-up study acute field infections were monitored in four young Thoroughbred horses until the ages of 12-13 months.
Gather, Theresa, Walter, Stephanie, Pfaender, Stephanie, Todt, Daniel, Feige, Karsten, Steinmann, Eike, Cavalleri, Jessika M V   +6 more
openaire   +5 more sources

Presence of two different bovine hepacivirus clusters in Germany

Transboundary and Emerging Diseases, 2018
During the last years, genetic information of hepaciviruses (family Flaviviridae), whose type species is the human hepatitis C virus, was detected in a wide range of primates and non-primate vertebrates. Here, samples collected from 263 German cattle kept in 22 different holdings were analysed for the presence of hepacivirus N (syn. bovine hepacivirus;
Kore Schlottau, Kerstin Wernike, Leonie Forth, Mark Holsteg, Dirk Höper, Martin Beer, Bernd Hoffmann   +6 more
openaire   +3 more sources

Detection and characterization of bovine hepacivirus in cattle and sheep from Hulunbuir, northeastern China [PDF]

Frontiers in Cellular and Infection Microbiology
BackgroundBovine hepacivirus (BovHepV) is a recently identified member of the expanding genus Hepacivirus within the family Flaviviridae. However, the genetic diversity, geographical distribution, and host range of the virus remains poorly understood ...
Zedong Wang, Zheng Xiangyu
exaly   +4 more sources

Mutational Analysis of the Bovine Hepacivirus Internal Ribosome Entry Site [PDF]

Journal of Virology, 2018
Several members of the family Flaviviridae , including HCV, have adapted cap-independent translation strategies to overcome canonical eukaryotic translation pathways and use cis -acting RNA-elements, designated viral internal ribosome entry sites (IRES), to initiate translation.
A L, Baron, A, Schoeniger, P, Becher, C, Baechlein   +3 more
openaire   +3 more sources

European College of Equine Internal Medicine consensus statement on equine flaviviridae infections in Europe

Journal of Veterinary Internal Medicine, 2022
Horses and other equids can be infected with several viruses of the family Flaviviridae, belonging to the genus Flavivirus and Hepacivirus. This consensus statement focuses on viruses with known occurrence in Europe, with the objective to summarize the ...
Jessika‐M. V. Cavalleri, Orsolya Korbacska‐Kutasi, Agnès Leblond, Romain Paillot, Nicola Pusterla, Eike Steinmann, Joy Tomlinson   +6 more
doaj   +1 more source

Dose-Dependent Hepacivirus Infection Reveals Linkage between Infectious Dose and Immune Response

Microbiology Spectrum, 2022
More than 70 million people worldwide are still infected with the hepatitis C virus 30 years after its discovery, underscoring the need for a vaccine. To develop an effective prophylactic vaccine, detailed knowledge of the correlates of protection and an
André Gömer, Julien Delarocque, Christina Puff, Maximilian K. Nocke, Birthe Reinecke, Wolfgang Baumgärtner, Jessika M. V. Cavalleri, Karsten Feige, Eike Steinmann, Daniel Todt   +9 more
doaj   +1 more source

Histopathology of chronic hepatitis C in relation to virus genotype [PDF]

Vojnosanitetski Pregled, 2006
Background/aim: The natural history of hepatitis C virus (HCV) infection is variable and the factors determining the course of the illness are unclear. There are geographical variations in the distribution of different HCV genotypes, and some of them are
Simonović Jasmina, Dokić Ljubiša, Čutović Milisav, Tomanović Nada, Boričić Ivan, Prostran Milica, Nešić Zorica, Delić Dragan, Švirtlih Neda   +8 more
doaj   +1 more source

Novel bovine hepacivirus in dairy cattle, China [PDF]

Emerging Microbes & Infections, 2018
Since it was first identified in 1989, Hepatitis C virus (HCV) has long been regarded as having one true natural host—humans1.
Lu, Gang, Jia, Kun, Ping, Xiaokun, Huang, Ji, Luo, Aijian, Wu, Peixin, Li, Shoujun   +6 more
openaire   +2 more sources