Results 21 to 30 of about 42,491 (161)

Novel bovine hepacivirus in dairy cattle, China [PDF]

Emerging Microbes & Infections, 2018
Since it was first identified in 1989, Hepatitis C virus (HCV) has long been regarded as having one true natural host—humans1.
Lu, Gang, Jia, Kun, Ping, Xiaokun, Huang, Ji, Luo, Aijian, Wu, Peixin, Li, Shoujun   +6 more
openaire   +2 more sources

Histopathology of chronic hepatitis C in relation to virus genotype [PDF]

Vojnosanitetski Pregled, 2006
Background/aim: The natural history of hepatitis C virus (HCV) infection is variable and the factors determining the course of the illness are unclear. There are geographical variations in the distribution of different HCV genotypes, and some of them are
Simonović Jasmina, Dokić Ljubiša, Čutović Milisav, Tomanović Nada, Boričić Ivan, Prostran Milica, Nešić Zorica, Delić Dragan, Švirtlih Neda   +8 more
doaj   +1 more source

Immune protection against reinfection with nonprimate hepacivirus [PDF]

Proceedings of the National Academy of Sciences, 2017
Significance Hepatitis C virus (HCV) displays a narrow species tropism severely hampering development of small animal models that are required for vaccine and pathogenesis studies in vivo. The recent discoveries of HCV-related hepaciviruses in diverse hosts offer new opportunities with respect to the development of an immunocompetent ...
Pfaender, Stephanie, Walter, Stephanie, Grabski, Elena, Todt, Daniel, Bruening, Janina, Romero-Brey, Inés, Gather, Theresa, Brown, Richard J P, Hahn, Kerstin, Puff, Christina, Pfankuche, Vanessa M, Hansmann, Florian, Postel, Alexander, Becher, Paul, Thiel, Volker, Kalinke, Ulrich, Wagner, Bettina, Bartenschlager, Ralf, Baumgärtner, Wolfgang, Feige, Karsten, Pietschmann, Thomas, Cavalleri, Jessika M V, Steinmann, Eike   +22 more
openaire   +4 more sources

The Detection and Phylogenetic Analysis of Bovine Hepacivirus in China [PDF]

BioMed Research International, 2018
Hepacivirus has been identified in cattle in Africa, Europe, and South America. In this survey of bovine hepacivirus (BovHepV) in 131 serum samples from Chinese cattle herds using RT-PCR, five of 131 sera were BovHepV positive, with the infection rate of 3.82%.
Yu Deng, Su Hua Guan, Silu Wang, Guiying Hao, Thomas Bruun Rasmussen   +4 more
openaire   +3 more sources

Identification of claudin-3 as an entry factor for rat hepacivirus. [PDF]

Proc Natl Acad Sci U S A
Approximately 58 million people worldwide are believed to be infected with hepatitis C virus (HCV), a major causative agent of chronic liver diseases. Hepacivirus ratti strain rn-1, which was discovered from Rattus norvegicus (Norway rat) and designated Norway rat hepacivirus 1 (NRHV1 ...
Tanaka T, Akaike Y, Kasai H, Yamashita A, Matsuura Y, Moriishi K.   +5 more
europepmc   +4 more sources

Hepatitis C virus (Flaviviridae: Hepacivirus: Hepacivirus C): regulation of signaling reactions of innate immunity

Problems of Virology, 2021
Studying the regulation of signaling reactions of innate immunity by the hepatitis C virus (HCV) will help to reveal the causes of the transition of the acute form of the disease to a chronic course. The molecular mechanisms of activation by HCV RNA of innate immunity receptors TLR and RLR and signal transduction processes leading to the synthesis of ...
openaire   +4 more sources

Hallmarks of Hepatitis C Virus in Equine Hepacivirus [PDF]

Journal of Virology, 2014
ABSTRACT Equine hepacivirus (EHcV) has been identified as a closely related homologue of hepatitis C virus (HCV) in the United States, the United Kingdom, and Germany, but not in Asian countries. In this study, we genetically and serologically screened 31 serum samples obtained from Japanese-born domestic horses for EHcV ...
Tomohisa, Tanaka, Hirotake, Kasai, Atsuya, Yamashita, Kaori, Okuyama-Dobashi, Jun, Yasumoto, Shinya, Maekawa, Nobuyuki, Enomoto, Toru, Okamoto, Yoshiharu, Matsuura, Masami, Morimatsu, Noboru, Manabe, Kazuhiko, Ochiai, Kazuto, Yamashita, Kohji, Moriishi   +13 more
openaire   +2 more sources

Description of an Equine Hepacivirus Cluster in a Horse Stable in Italy

Transboundary and Emerging Diseases, 2023
Equine hepacivirus (EqHV), also known as Hepacivirus A, represents the most closely related genetic homologue of human hepatitis C virus (HCV). Although detected worldwide, limited information on the clinical features of this infection is available and on the mechanisms by which EqHV is transmitted.
Roberta Cardone, Alessio Buonavoglia, Gianvito Lanave, Violetta Iris Vasinioti, Valentina Mininni, Eleonora Lorusso, Nicola Decaro, Vito Martella, Gabriella Elia, Georgia Diakoudi   +9 more
openaire   +3 more sources

The Bank Vole (Clethrionomys glareolus)—Small Animal Model for Hepacivirus Infection

Viruses, 2021
Many people worldwide suffer from hepatitis C virus (HCV) infection, which is frequently persistent. The lack of efficient vaccines against HCV and the unavailability of or limited compliance with existing antiviral therapies is problematic for health ...
Susanne Röhrs, Lineke Begeman, Beate K. Straub, Mariana Boadella, Dennis Hanke, Kerstin Wernike, Stephan Drewes, Bernd Hoffmann, Markus Keller, Jan Felix Drexler, Christian Drosten, Dirk Höper, Thijs Kuiken, Rainer G. Ulrich, Martin Beer   +14 more
doaj   +1 more source

Further Evidence for in Utero Transmission of Equine Hepacivirus to Foals [PDF]

Viruses, 2019
(1) Background: Equine hepacivirus (EqHV), also referred to as non-primate hepacivirus (NPHV), infects horses—and dogs in some instances—and is closely related to hepatitis C virus (HCV) that has infected up to 3% of the world’s human population, causing an epidemic of liver cirrhosis and cancer.
Pronost, Stéphane, Fortier, Christine, Marcillaud-Pitel, Christel, Tapprest, Jackie, Foursin, Marc, Saunier, Bertrand, Pitel, Pierre-Hugues, Paillot, Romain, Hue, Erika   +8 more
openaire   +4 more sources