Results 21 to 30 of about 44,632 (207)
Novel bovine hepacivirus in dairy cattle, China [PDF]
Emerging Microbes & Infections, 2018 Since it was first identified in 1989, Hepatitis C virus (HCV) has long been regarded as having one true natural host—humans1.
Lu, Gang +6 more
openaire +2 more sources
Molecular Determinants of Mouse Adaptation of Rat Hepacivirus
Journal of Virology, 2023 A prophylactic vaccine is required to achieve the World Health Organization’s objective for hepatitis C virus elimination as a serious public health threat. However, the lack of robust immunocompetent animal models supporting hepatitis C virus infection impedes vaccine development as well as studies of immune responses and viral evasion.
Wolfisberg, Raphael +11 more
openaire +3 more sources
Dose-Dependent Hepacivirus Infection Reveals Linkage between Infectious Dose and Immune Response
Microbiology Spectrum, 2022 More than 70 million people worldwide are still infected with the hepatitis C virus 30 years after its discovery, underscoring the need for a vaccine. To develop an effective prophylactic vaccine, detailed knowledge of the correlates of protection and an
André Gömer +9 more
doaj +1 more source
Histopathology of chronic hepatitis C in relation to virus genotype [PDF]
Vojnosanitetski Pregled, 2006 Background/aim: The natural history of hepatitis C virus (HCV) infection is variable and the factors determining the course of the illness are unclear. There are geographical variations in the distribution of different HCV genotypes, and some of them are
Simonović Jasmina +8 more
doaj +1 more source
The landscape of viral associations in human cancers [PDF]
, 2020 Here, as part of the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, for which whole-genome and—for a subset—whole-transcriptome sequencing data from 2,658 cancers across 38 tumor types was aggregated, we systematically investigated potential ...
Alawi, Malik +14 more
core +3 more sources
Problems of Virology, 2021 Studying the regulation of signaling reactions of innate immunity by the hepatitis C virus (HCV) will help to reveal the causes of the transition of the acute form of the disease to a chronic course. The molecular mechanisms of activation by HCV RNA of innate immunity receptors TLR and RLR and signal transduction processes leading to the synthesis of ...
openaire +4 more sources
Blocking Zika virus vertical transmission. [PDF]
, 2018 The outbreak of the Zika virus (ZIKV) has been associated with increased incidence of congenital malformations. Although recent efforts have focused on vaccine development, treatments for infected individuals are needed urgently. Sofosbuvir (SOF), an FDA-
Beltrão-Braga, Patricia CB +23 more
core +2 more sources
Mouse models of acute and chronic hepacivirus infection [PDF]
Science, 2017 New York City rats provide a gift to virologists Despite the development of curative drugs for hepatitis C virus (HCV) infection, global eradication of HCV will likely require a prophylactic vaccine. Progress toward a vaccine has been impeded by the absence of mouse models suitable for studying the immune response
Eva Billerbeck +14 more
openaire +3 more sources
Hallmarks of Hepatitis C Virus in Equine Hepacivirus [PDF]
Journal of Virology, 2014 ABSTRACT Equine hepacivirus (EHcV) has been identified as a closely related homologue of hepatitis C virus (HCV) in the United States, the United Kingdom, and Germany, but not in Asian countries. In this study, we genetically and serologically screened 31 serum samples obtained from Japanese-born domestic horses for EHcV ...
Tomohisa, Tanaka +13 more
openaire +2 more sources
Non-primate hepacivirus infection with apparent hepatitis in a horse — Short communication [PDF]
, 2014 Non-primate hepacivirus (NPHV) is a recently identified hepacivirus (family Flaviviridae) in dog and horse; however, the disease associations remain unknown.
Boros, Ákos +3 more
core +1 more source