Results 11 to 20 of about 42,842 (184)

An Equine Model for Vaccination against a Hepacivirus: Insights into Host Responses to E2 Recombinant Protein Vaccination and Subsequent Equine Hepacivirus Inoculation [PDF]

Viruses, 2022
Equine hepacivirus (EqHV) is the closest known genetic homologue of hepatitis C virus. An effective prophylactic vaccine is currently not available for either of these hepaciviruses. The equine as potential surrogate model for hepacivirus vaccine studies
Marcha Badenhorst, Armin Saalmüller, Janet M. Daly, Reinhard Ertl, Maria Stadler, Christina Puff, Madeleine de le Roi, Wolfgang Baumgärtner, Michael Engelmann, Sabine Brandner, Hannah K. Junge, Barbara Pratscher, Asisa Volz, Bertrand Saunier, Thomas Krey, Johannes Wittmann, Steffen Heelemann, Julien Delarocque, Bettina Wagner, Daniel Todt, Eike Steinmann, Jessika-M. V. Cavalleri   +21 more
doaj   +10 more sources

Chronic hepatitis in horses with persistent equine hepacivirus infection. [PDF]

Equine Vet J
Abstract Background Equine hepacivirus (EqHV) is closely related to hepatitis C virus (HCV), which causes persistent infection and chronic hepatitis in people. Information on persistent EqHV infection and hepatitis is limited. Objectives To report 19 cases of chronic hepatitis and persistent EqHV infection.
Jager MC, Luethy D, Shallop S, Cathcart J, Divers TJ, Tan JY, Beasley EM, Johnson P, Leduc L, Smith C, Jamieson CA, Magdesian KG, Van de Walle GR, Tomlinson JE.   +13 more
europepmc   +4 more sources

First Detection and Phylogenetic Analysis of Equine Hepacivirus (EqHV) in Iran. [PDF]

Vet Med Sci
This study presents the first detection of Hepacivirus equi (EqHV) in the equine population of Khuzestan Province, Iran. Molecular analysis revealed a prevalence rate of 4.66%, while phylogenetic analysis confirmed that the strain IR1‐Ahvaz‐2024 belongs to EqHV subtype 1.
Pourmahdi Borujeni M, Ghobadian Diali H, Mashhadi AG, Aliabad MJ.   +3 more
europepmc   +3 more sources

First identification of bovine hepacivirus in wild boars

Scientific Reports, 2022
Hepatitis C virus (HCV) is a major cause of chronic hepatitis, cirrhosis and hepatocellular carcinoma in humans. Humans were long considered the only hosts of Hepacivirus.
Claudio de Martinis, Lorena Cardillo, Claudia Esposito, Maurizio Viscardi, Lorella Barca, Stefania Cavallo, Nicola D’Alessio, Vito Martella, Giovanna Fusco   +8 more
doaj   +3 more sources

The Detection and Phylogenetic Analysis of Bovine Hepacivirus in China [PDF]

BioMed Research International, 2018
Hepacivirus has been identified in cattle in Africa, Europe, and South America. In this survey of bovine hepacivirus (BovHepV) in 131 serum samples from Chinese cattle herds using RT-PCR, five of 131 sera were BovHepV positive, with the infection rate of 3.82%.
Yu Deng, Su Hua Guan, Silu Wang, Guiying Hao, Thomas Bruun Rasmussen   +4 more
openaire   +5 more sources

Molecular Determinants of Mouse Adaptation of Rat Hepacivirus

Journal of Virology, 2023
A prophylactic vaccine is required to achieve the World Health Organization’s objective for hepatitis C virus elimination as a serious public health threat. However, the lack of robust immunocompetent animal models supporting hepatitis C virus infection impedes vaccine development as well as studies of immune responses and viral evasion.
Wolfisberg, Raphael, Holmbeck, Kenn, Billerbeck, Eva, Thorselius, Caroline E., Batista, Mariana N., Fahnøe, Ulrik, Lundsgaard, Emma A., Kennedy, Matthew J., Nielsen, Louise, Rice, Charles M., Bukh, Jens, Scheel, Troels K. H.   +11 more
openaire   +4 more sources

Immune protection against reinfection with nonprimate hepacivirus [PDF]

Proceedings of the National Academy of Sciences, 2017
Significance Hepatitis C virus (HCV) displays a narrow species tropism severely hampering development of small animal models that are required for vaccine and pathogenesis studies in vivo. The recent discoveries of HCV-related hepaciviruses in diverse hosts offer new opportunities with respect to the development of an immunocompetent animal ...
Pfaender, Stephanie, Walter, Stephanie, Grabski, Elena, Todt, Daniel, Bruening, Janina, Romero-Brey, Inés, Gather, Theresa, Brown, Richard J P, Hahn, Kerstin, Puff, Christina, Pfankuche, Vanessa M, Hansmann, Florian, Postel, Alexander, Becher, Paul, Thiel, Volker, Kalinke, Ulrich, Wagner, Bettina, Bartenschlager, Ralf, Baumgärtner, Wolfgang, Feige, Karsten, Pietschmann, Thomas, Cavalleri, Jessika M V, Steinmann, Eike   +22 more
openaire   +5 more sources

Further Evidence for in Utero Transmission of Equine Hepacivirus to Foals [PDF]

Viruses, 2019
(1) Background: Equine hepacivirus (EqHV), also referred to as non-primate hepacivirus (NPHV), infects horses—and dogs in some instances—and is closely related to hepatitis C virus (HCV) that has infected up to 3% of the world’s human population, causing an epidemic of liver cirrhosis and cancer.
Pronost, Stéphane, Fortier, Christine, Marcillaud-Pitel, Christel, Tapprest, Jackie, Foursin, Marc, Saunier, Bertrand, Pitel, Pierre-Hugues, Paillot, Romain, Hue, Erika   +8 more
openaire   +5 more sources

Presence of bovine hepacivirus in Turkish cattle

Veterinary Microbiology, 2018
Hepatitis C virus (HCV), a worldwide distributed human pathogen, causes one of the most important viral infections in human being. HCV is the type species of the genus Hepacivirus (Flaviviridae) in which recently discovered animal viruses i.e. from horses, bats, rodents and cattle are allocated. After preliminary reports in 2015 from German and African
Alpay, GİZEM, YEŞİLBAĞ, KADİR, KADİROĞLU, BERFİN, Toker, EDA BALDAN, Becher, Paul, Baechlein, Christine   +5 more
openaire   +4 more sources

Discovery of Jogalong virus, a novel hepacivirus identified in a Culex annulirostris (Skuse) mosquito from the Kimberley region of Western Australia.

PLoS ONE, 2020
The discovery of hepaciviruses in non-human hosts has accelerated following the advancement of high-throughput sequencing technology. Hepaciviruses have now been described in reptiles, fish, birds, and an extensive array of mammals.
Simon H Williams, Avram Levy, Rachel A Yates, Nilusha Somaweera, Peter J Neville, Jay Nicholson, Michael D A Lindsay, John S Mackenzie, Komal Jain, Allison Imrie, David W Smith, W Ian Lipkin   +11 more
doaj   +2 more sources