Results 11 to 20 of about 42,491 (161)

First identification of bovine hepacivirus in wild boars

Scientific Reports, 2022
Hepatitis C virus (HCV) is a major cause of chronic hepatitis, cirrhosis and hepatocellular carcinoma in humans. Humans were long considered the only hosts of Hepacivirus.
Claudio de Martinis, Lorena Cardillo, Claudia Esposito, Maurizio Viscardi, Lorella Barca, Stefania Cavallo, Nicola D’Alessio, Vito Martella, Giovanna Fusco   +8 more
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An Equine Model for Vaccination against a Hepacivirus: Insights into Host Responses to E2 Recombinant Protein Vaccination and Subsequent Equine Hepacivirus Inoculation

Viruses, 2022
Equine hepacivirus (EqHV) is the closest known genetic homologue of hepatitis C virus. An effective prophylactic vaccine is currently not available for either of these hepaciviruses. The equine as potential surrogate model for hepacivirus vaccine studies
Marcha Badenhorst, Armin Saalmüller, Janet M. Daly, Reinhard Ertl, Maria Stadler, Christina Puff, Madeleine de le Roi, Wolfgang Baumgärtner, Michael Engelmann, Sabine Brandner, Hannah K. Junge, Barbara Pratscher, Asisa Volz, Bertrand Saunier, Thomas Krey, Johannes Wittmann, Steffen Heelemann, Julien Delarocque, Bettina Wagner, Daniel Todt, Eike Steinmann, Jessika-M. V. Cavalleri   +21 more
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Editorial: Advances in ruminant viruses [PDF]

Frontiers in Cellular and Infection Microbiology
Muthannan Andavar Ramakrishnan, Santhamani Ramasamy   +1 more
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Identification of a Novel Hepacivirus in Southeast Asian Shrew (Crocidura fuliginosa) from Yunnan Province, China

Pathogens, 2023
The genus Hepacivirus contains single-stranded positive-sense RNA viruses belonging to the family Flaviviridae, which comprises 14 species. These 14 hepaciviruses have been found in different mammals, such as primates, dogs, bats, and rodents.
Ling Guo, Bei Li, Peiyu Han, Na Dong, Yan Zhu, Fuli Li, Haorui Si, Zhengli Shi, Bo Wang, Xinglou Yang, Yunzhi Zhang   +10 more
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Hepatic iNKT cells produce type 2 cytokines and restrain antiviral T cells during acute hepacivirus infection

Frontiers in Immunology, 2022
Chronic hepatitis C virus (HCV) infection is a curable disease, but the absence of a vaccine remains a major problem in infection prevention. The lack of small animal models and limited access to human liver tissue impede the study of hepatic antiviral ...
Svjetlana Raus, Jarrett Lopez-Scarim, Joshua Luthy, Eva Billerbeck   +3 more
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Molecular Determinants of Mouse Adaptation of Rat Hepacivirus

Journal of Virology, 2023
A prophylactic vaccine is required to achieve the World Health Organization’s objective for hepatitis C virus elimination as a serious public health threat. However, the lack of robust immunocompetent animal models supporting hepatitis C virus infection impedes vaccine development as well as studies of immune responses and viral evasion.
Wolfisberg, Raphael, Holmbeck, Kenn, Billerbeck, Eva, Thorselius, Caroline E., Batista, Mariana N., Fahnøe, Ulrik, Lundsgaard, Emma A., Kennedy, Matthew J., Nielsen, Louise, Rice, Charles M., Bukh, Jens, Scheel, Troels K. H.   +11 more
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European College of Equine Internal Medicine consensus statement on equine flaviviridae infections in Europe

Journal of Veterinary Internal Medicine, 2022
Horses and other equids can be infected with several viruses of the family Flaviviridae, belonging to the genus Flavivirus and Hepacivirus. This consensus statement focuses on viruses with known occurrence in Europe, with the objective to summarize the ...
Jessika‐M. V. Cavalleri, Orsolya Korbacska‐Kutasi, Agnès Leblond, Romain Paillot, Nicola Pusterla, Eike Steinmann, Joy Tomlinson   +6 more
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Dose-Dependent Hepacivirus Infection Reveals Linkage between Infectious Dose and Immune Response

Microbiology Spectrum, 2022
More than 70 million people worldwide are still infected with the hepatitis C virus 30 years after its discovery, underscoring the need for a vaccine. To develop an effective prophylactic vaccine, detailed knowledge of the correlates of protection and an
André Gömer, Julien Delarocque, Christina Puff, Maximilian K. Nocke, Birthe Reinecke, Wolfgang Baumgärtner, Jessika M. V. Cavalleri, Karsten Feige, Eike Steinmann, Daniel Todt   +9 more
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Mouse models of acute and chronic hepacivirus infection [PDF]

Science, 2017
New York City rats provide a gift to virologists Despite the development of curative drugs for hepatitis C virus (HCV) infection, global eradication of HCV will likely require a prophylactic vaccine. Progress toward a vaccine has been impeded by the absence of mouse models suitable for studying the immune response
Eva Billerbeck, Raphael Wolfisberg, Ulrik Fahnøe, Jing W. Xiao, Corrine Quirk, Joseph M. Luna, John M. Cullen, Alex S. Hartlage, Luis Chiriboga, Kalpana Ghoshal, W. Ian Lipkin, Jens Bukh, Troels K. H. Scheel, Amit Kapoor, Charles M. Rice   +14 more
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Discovery of Jogalong virus, a novel hepacivirus identified in a Culex annulirostris (Skuse) mosquito from the Kimberley region of Western Australia.

PLoS ONE, 2020
The discovery of hepaciviruses in non-human hosts has accelerated following the advancement of high-throughput sequencing technology. Hepaciviruses have now been described in reptiles, fish, birds, and an extensive array of mammals.
Simon H Williams, Avram Levy, Rachel A Yates, Nilusha Somaweera, Peter J Neville, Jay Nicholson, Michael D A Lindsay, John S Mackenzie, Komal Jain, Allison Imrie, David W Smith, W Ian Lipkin   +11 more
doaj   +1 more source