Human platelets and their capacity of binding viruses: Meaning and challenges? [PDF]
, 2015 Blood platelets are first aimed at ensuring primary hemostasis. Beyond this role, they have been acknowledged as having functions in the maintenance of the vascular arborescence and, more recently, as being also innate immune cells, devoted notably to ...
Chabert, Adrien +6 more
core +2 more sources
Treatment of anicteric acute hepatitis C with peginterferon alpha-2a plus ribavirin [PDF]
Vojnosanitetski Pregled, 2005 Background. Hepatitis C virus (HCV) infection is the most frequent cause of chronic hepatitis, cirrhosis, and hepatocellular carcinoma in the world. Acute hepatitis C is the most commonly asymptomatic liver disease with the development of chronic HCV ...
Delić Dragan +4 more
doaj +1 more source
Hepatitis C Virus and Hepatocellular Carcinoma: Pathogenetic Mechanisms and Impact of Direct-Acting Antivirals [PDF]
, 2018 INTRODUCTION: Globally, between 64 and 103 million people are chronically infected with Hepatitis C virus (HCV), with more than 4.6 million people in the United States and is associated with more than 15.000 deaths annually.
Petruzziello, Arnolfo +5 more
core +1 more source
Therapy of acute hepatitis C infection [PDF]
Vojnosanitetski Pregled, 2005 Background. Hepatitis C viral infection is a major cause of chronic hepatitis, liver cirrhosis and hepatocellular carcinoma. The progression of acute to chronic infection occurs in 50-90% of cases.
Đokić Milomir, Begović Vesna
doaj +1 more source
Development of Optimized Inhibitor RNAs Allowing Multisite-Targeting of the HCV Genome [PDF]
, 2017 : Engineered multivalent drugs are promising candidates for fighting infection by highly variable viruses, such as HCV. The combination into a single molecule of more than one inhibitory domain, each with its own target specificity and even a different ...
Berzal-Herranz, Alfredo +3 more
core +1 more source
HepacivirusInfection in Domestic Horses, Brazil, 2011–2013
Emerging Infectious Diseases, 2014 To the Editor: An estimated ≈150 million persons (3% of the world population) are chronically infected with hepatitis C virus (HCV). This virus is the prototype of the genus Hepacivirus and a major cause of liver cirrhosis and hepatocellular carcinoma around the world.
Bernard Salame Gemaque +13 more
openaire +3 more sources
Acute and chronic infections with nonprimate hepacivirus in young horses [PDF]
Veterinary Research, 2016 The recently discovered nonprimate hepacivirus (NPHV) naturally infects horses and is the closest known homolog of hepatitis C virus to date. Within a follow-up study acute field infections were monitored in four young Thoroughbred horses until the ages of 12-13 months.
Gather, Theresa +6 more
openaire +4 more sources
Dissemination of Internal Ribosomal Entry Sites (IRES) Between Viruses by Horizontal Gene Transfer
Viruses, 2020 Members of Picornaviridae and of the Hepacivirus, Pegivirus and Pestivirus genera of Flaviviridae all contain an internal ribosomal entry site (IRES) in the 5′-untranslated region (5′UTR) of their genomes. Each class of IRES has a conserved structure and
Yani Arhab +3 more
doaj +1 more source
Mutational Analysis of the Bovine Hepacivirus Internal Ribosome Entry Site [PDF]
Journal of Virology, 2018 Several members of the family Flaviviridae , including HCV, have adapted cap-independent translation strategies to overcome canonical eukaryotic translation pathways and use cis -acting RNA-elements, designated viral internal ribosome entry sites (IRES), to initiate translation.
A L, Baron +3 more
openaire +2 more sources
Including osteoprotegerin and collagen IV in a score-based blood test for liver fibrosis increases diagnostic accuracy [PDF]
, 2013 BACKGROUND: Noninvasive methods for liver fibrosis evaluation in chronic liver diseases have been recently developed, i.e. transient elastography (Fibroscan™) and blood tests (Fibrometer®, Fibrotest®, and Hepascore®).
ANRS HCEP 23 Fibrostar Group +12 more
core +2 more sources