Results 41 to 50 of about 42,491 (161)

Characterization of nonprimate hepacivirus and construction of a functional molecular clone [PDF]

Proceedings of the National Academy of Sciences, 2015
Significance The origin of hepatitis C virus (HCV) has long remained a mystery. Unexpectedly, a plethora of HCV-related hepaciviruses was recently discovered in horses, monkeys, rodents, and bats. These discoveries are of particular interest and may aid in understanding HCV evolution, molecular biology, and natural history. Currently,
Troels K. H. Scheel, Amit Kapoor, Eiko Nishiuchi, Kenny V. Brock, Yingpu Yu, Linda Andrus, Meigang Gu, Randall W. Renshaw, Edward J. Dubovi, Sean P. McDonough, Gerlinde R. Van de Walle, W. Ian Lipkin, Thomas J. Divers, Bud C. Tennant, Charles M. Rice   +14 more
openaire   +3 more sources

Dissemination of Internal Ribosomal Entry Sites (IRES) Between Viruses by Horizontal Gene Transfer

Viruses, 2020
Members of Picornaviridae and of the Hepacivirus, Pegivirus and Pestivirus genera of Flaviviridae all contain an internal ribosomal entry site (IRES) in the 5′-untranslated region (5′UTR) of their genomes. Each class of IRES has a conserved structure and
Yani Arhab, Alexander G. Bulakhov, Tatyana V. Pestova, Christopher U.T. Hellen   +3 more
doaj   +1 more source

Predictive value of protein kinase C delta as a diagnostic biomarker for hepatocellular carcinoma in hepatitis C virus-related cirrhosis [PDF]

Scripta Medica
Background/Aim: Hepatocellular carcinoma (HCC) is considered the 6th prevalent tumour and 3rd leading cause of cancer-associated mortality worldwide. Protein kinase C delta (PKCδ), released by liver cancer cells, has an effect in cell-proliferation and ...
Amer Heba, Elfakhry A., Abd El-Hafez Afaf, El Arman Mohammed M., Abozeid Fatma   +4 more
doaj   +1 more source

Design and Synthesis of Novel Imidazo[4,5‐c]pyridine Derivatives, Evaluation of Their Activity Against Hepatitis C Virus and In Silico Prediction of Their Binding Mode to NS4B Protein

ChemMedChem, Volume 21, Issue 13, 14 July 2026.
A series of 18 novel imidazo[4,5‐c]pyridines was synthesized, and their anti‐HCV activity was evaluated. Compound 30b was identified as the most promising one, with EC50 = 6.61 µM. Molecular docking studies indicated the NS4B protein of the HCV as a potential target of these derivatives.
Eftychia Karampella, George Mpekoulis, Maria Georgiou, Iris Kolida, Katerina I. Kalliampakou, Eirini P. Kollia, Eleni V. Mikropoulou, Maria Halabalaki, Christos T. Chasapis, Niki Vassilaki, Nikolaos Lougiakis   +10 more
wiley   +1 more source

Canine hepacivirus is not associated with chronic liver disease in dogs [PDF]

Journal of Viral Hepatitis, 2013
SummaryCanine hepacivirus (CHV) has recently been identified in liver and respiratory tract samples from dogs, and comparative phylogenetic analysis has confirmed it to be the closest genetic relative of hepatitis C virus (HCV) described to date. CHV offers great potential as a model system for HCV, but only if the underlying processes of infection and
Bexfield, N. H., Watson, P. J., Heaney, J., Heeney, J. L., Tiley, L.   +4 more
openaire   +2 more sources

Successful use of haemoperfusion therapy in an adult horse with hepatic encephalopathy and cholangiohepatitis

Equine Veterinary Education, Volume 38, Issue 6, Page e307-e314, June 2026.
Summary A 4‐year‐old, 520 kg, American Quarter Horse broodmare, approximately 90 days in foal, was presented to Texas A&M University Teaching Hospital for suspected liver disease. Based on clinicopathological values and hepatic abnormalities noted ultrasonographically, the mare was presumptively diagnosed with cholangiohepatitis.
A. C. Trimble, S. H. White‐Springer, S. Alpini, E. Rumfola, A. N. DiSilvestro, Y. Ueda, K. Hobbs   +6 more
wiley   +1 more source

Detection and Characterization of Homologues of Human Hepatitis Viruses and Pegiviruses in Rodents and Bats in Vietnam

Viruses, 2018
Rodents and bats are now widely recognised as important sources of zoonotic virus infections in other mammals, including humans. Numerous surveys have expanded our knowledge of diverse viruses in a range of rodent and bat species, including their origins,
Dung Van Nguyen, Cuong Van Nguyen, David Bonsall, Tue Tri Ngo, Juan Carrique-Mas, Anh Hong Pham, Juliet E. Bryant, Guy Thwaites, Stephen Baker, Mark Woolhouse, Peter Simmonds   +10 more
doaj   +1 more source

Dengue Virus Capsid Protein Interaction With Nucleic Acids

BioFactors, Volume 52, Issue 3, May/June 2026.
Binding of dengue virus capsid protein (DENV C) to ssDNA alters Trp fluorescence intensity, lifetime, and anisotropy, revealing structural rearrangements in the complex and suggesting a possible association with liquid–liquid phase separation (LLPS). ABSTRACT Dengue virus (DENV) transmission has greatly increased in the last decade, partly due to the ...
Nelly M. Silva, Ana S. Martins, Nina E. Karguth, Maria J. Sarmento, Francisco J. Enguita, Roland G. Huber, Ivo C. Martins, Nuno C. Santos   +7 more
wiley   +1 more source

Viruses in Horses with Neurologic and Respiratory Diseases

Viruses, 2019
Metagenomics was used to identify viral sequences in the plasma and CSF (cerobrospinal fluid) of 13 horses with unexplained neurological signs and in the plasma and respiratory swabs of 14 horses with unexplained respiratory signs. Equine hepacivirus and
Eda Altan, Yanpeng Li, Gilberto Sabino-Santos Jr, Vorthon Sawaswong, Samantha Barnum, Nicola Pusterla, Xutao Deng, Eric Delwart   +7 more
doaj   +1 more source

Refractory Hepatic Hydrothorax in Chronic Hepatitis C Controlled by Direct-acting Antivirals

The Korean Journal of Gastroenterology, 2020
Hepatic hydrothorax is a transudative pleural effusion that complicates advanced liver cirrhosis. Patients refractory to medical treatment plus salt restriction and diuretics are considered to have refractory hepatic hydrothorax and may require ...
Myung Hee Kim, Duk Ki Kim, Hyuk Soo Eun, Woo Sun Rou, Seok Hyun Kim, Byung Seok Lee   +5 more
doaj   +1 more source