Results 21 to 30 of about 16,295 (220)
A novel subtype of bovine hepacivirus identified in ticks reveals the genetic diversity and evolution of bovine hepacivirus [PDF]
Viruses, 2021 Hepaciviruses represent a group of viruses that pose a significant threat to the health of humans and animals. New members of the genus Hepacivirus in the family Flaviviridae have recently been identified in a wide variety of host species worldwide. Similar to the Hepatitis C virus (HCV), bovine hepacivirus (BovHepV) is hepatotropic and causes acute or
Jian‐Wei Shao
+9 more sources
Molecular Determinants of Mouse Adaptation of Rat Hepacivirus
Journal of Virology, 2023 A prophylactic vaccine is required to achieve the World Health Organization’s objective for hepatitis C virus elimination as a serious public health threat. However, the lack of robust immunocompetent animal models supporting hepatitis C virus infection impedes vaccine development as well as studies of immune responses and viral evasion.
Raphael Wolfisberg +11 more
openalex +5 more sources
Detection and characterization of bovine hepacivirus in cattle and sheep from Hulunbuir, northeastern China. [PDF]
Front Cell Infect MicrobiolMa J +8 more
europepmc +3 more sources
Novel hepacivirus in Asian house shrew, China [PDF]
Science China Life Sciences, 2019 Hua Guo +13 more
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Immune protection against reinfection with nonprimate hepacivirus [PDF]
Proceedings of the National Academy of Sciences, 2017 Significance Hepatitis C virus (HCV) displays a narrow species tropism severely hampering development of small animal models that are required for vaccine and pathogenesis studies in vivo. The recent discoveries of HCV-related hepaciviruses in diverse hosts offer new opportunities with respect to the development of an immunocompetent animal ...
Stephanie Pfaender +22 more
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Mouse models of acute and chronic hepacivirus infection [PDF]
Science, 2017 New York City rats provide a gift to virologists Despite the development of curative drugs for hepatitis C virus (HCV) infection, global eradication of HCV will likely require a prophylactic vaccine. Progress toward a vaccine has been impeded by the absence of mouse models suitable for studying the immune response to HCV ...
Eva Billerbeck +14 more
openalex +5 more sources
Mutational Analysis of the Bovine Hepacivirus Internal Ribosome Entry Site [PDF]
Journal of Virology, 2018 Several members of the family Flaviviridae , including HCV, have adapted cap-independent translation strategies to overcome canonical eukaryotic translation pathways and use cis -acting RNA-elements, designated viral internal ribosome entry sites (IRES), to initiate translation.
Anna Lena Baron +3 more
openalex +4 more sources
Detection of Equine Parvovirus-Hepatitis Virus and Equine Hepacivirus in Archived Sera from Horses in France and Australia. [PDF]
VirusesFortier C +12 more
europepmc +3 more sources
Viruses, 2022 Hepaciviruses represent a group of viruses that pose a significant threat to the health of humans and animals. During the last decade, new members of the genus Hepacivirus have been identified in various host species worldwide, indicating the widespread ...
Xue-Lian Zhang +6 more
doaj +1 more source