Results 31 to 40 of about 41,094 (191)

Seroepidemiology of non-primate hepacivirus (NPHV) in Japanese native horses

Journal of Veterinary Medical Science, 2017
Non-primate hepacivirus (NPHV) is recently identified as a closely related homologue of hepatitis C virus. The previous studies showed a high prevalence of NPHV infection among Japanese domestic horses originated from abroad. The historical distribution of NPHV among horses in Japan, therefore, is still unknown. In this study, seroepidemiological study
Shizuka Hayashi, Tomohisa Tanaka, Kohji Moriishi, Kazuhiro Hirayama, Akio Yamada, Kozue Hotta   +5 more
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Protein Interactions during the Flavivirus and Hepacivirus Life Cycle [PDF]

Molecular & Cellular Proteomics, 2017
Protein-protein interactions govern biological functions in cells, in the extracellular milieu, and at the border between cells and extracellular space. Viruses are small intracellular parasites and thus rely on protein interactions to produce progeny inside host cells and to spread from cell to cell.
Gisa Gerold, Janina Bruening, Bettina Weigel, Thomas Pietschmann   +3 more
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Hepatic iNKT cells produce type 2 cytokines and restrain antiviral T cells during acute hepacivirus infection

Frontiers in Immunology, 2022
Chronic hepatitis C virus (HCV) infection is a curable disease, but the absence of a vaccine remains a major problem in infection prevention. The lack of small animal models and limited access to human liver tissue impede the study of hepatic antiviral ...
Svjetlana Raus, Jarrett Lopez-Scarim, Joshua Luthy, Eva Billerbeck   +3 more
doaj   +1 more source

Molecular Determinants of Mouse Adaptation of Rat Hepacivirus

Journal of Virology, 2023
A prophylactic vaccine is required to achieve the World Health Organization’s objective for hepatitis C virus elimination as a serious public health threat. However, the lack of robust immunocompetent animal models supporting hepatitis C virus infection impedes vaccine development as well as studies of immune responses and viral evasion.
Wolfisberg, Raphael, Holmbeck, Kenn, Billerbeck, Eva, Thorselius, Caroline E., Batista, Mariana N., Fahnøe, Ulrik, Lundsgaard, Emma A., Kennedy, Matthew J., Nielsen, Louise, Rice, Charles M., Bukh, Jens, Scheel, Troels K. H.   +11 more
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European College of Equine Internal Medicine consensus statement on equine flaviviridae infections in Europe

Journal of Veterinary Internal Medicine, 2022
Horses and other equids can be infected with several viruses of the family Flaviviridae, belonging to the genus Flavivirus and Hepacivirus. This consensus statement focuses on viruses with known occurrence in Europe, with the objective to summarize the ...
Jessika‐M. V. Cavalleri, Orsolya Korbacska‐Kutasi, Agnès Leblond, Romain Paillot, Nicola Pusterla, Eike Steinmann, Joy Tomlinson   +6 more
doaj   +1 more source

Prevalence of equine hepacivirus infection in Mongolia

Virus Research, 2020
Equine hepacivirus (EHV) belongs to the hepacivirus A and is related to hepatitis C virus (HCV). This virus shows hepatic tropism and is known to chronically infect horses. EHV has been reported from various countries, but the prevalence in Mongolia, where large horse populations are pastured, remains unknown.
Tomoko, Date, Masaya, Sugiyama, Damdindorj, Lkhagvasuren, Takaji, Wakita, Tsendsuren, Oyunsuren, Masashi, Mizokami   +5 more
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Discovery of Jogalong virus, a novel hepacivirus identified in a Culex annulirostris (Skuse) mosquito from the Kimberley region of Western Australia.

PLoS ONE, 2020
The discovery of hepaciviruses in non-human hosts has accelerated following the advancement of high-throughput sequencing technology. Hepaciviruses have now been described in reptiles, fish, birds, and an extensive array of mammals.
Simon H Williams, Avram Levy, Rachel A Yates, Nilusha Somaweera, Peter J Neville, Jay Nicholson, Michael D A Lindsay, John S Mackenzie, Komal Jain, Allison Imrie, David W Smith, W Ian Lipkin   +11 more
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Chronic equine hepacivirus infection in an adult gelding with severe hepatopathy [PDF]

Veterinary Medicine and Science, 2019
AbstractBackground: Equine hepacivirus (EqHV) in equids represents the closest homologue to hepatitis C virus (HCV) infecting humans. A majority ofHCVinfected patients develop a chronic course of infection leading to liver fibrosis, cirrhosis and liver failure. However, in horses mostly transient mild subclinical infections are reported for EqHVto date.
Birthe Tegtmeyer, Julia Echelmeyer, Vanessa M. Pfankuche, Christina Puff, Daniel Tödt, Nicole Fischer, Andy E. Durham, Karsten Feige, Wolfgang Baumgärtner, Eike Steinmann, Jessika‐M. V. Cavalleri   +10 more
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Histopathology of chronic hepatitis C in relation to virus genotype [PDF]

Vojnosanitetski Pregled, 2006
Background/aim: The natural history of hepatitis C virus (HCV) infection is variable and the factors determining the course of the illness are unclear. There are geographical variations in the distribution of different HCV genotypes, and some of them are
Simonović Jasmina, Dokić Ljubiša, Čutović Milisav, Tomanović Nada, Boričić Ivan, Prostran Milica, Nešić Zorica, Delić Dragan, Švirtlih Neda   +8 more
doaj   +1 more source

Mouse models of acute and chronic hepacivirus infection [PDF]

Science, 2017
New York City rats provide a gift to virologists Despite the development of curative drugs for hepatitis C virus (HCV) infection, global eradication of HCV will likely require a prophylactic vaccine. Progress toward a vaccine has been impeded by the absence of mouse models suitable for studying the immune response to HCV ...
Eva Billerbeck, Raphael Wolfisberg, Ulrik Fahnøe, Jing W. Xiao, Corrine Quirk, Joseph M. Luna, John M. Cullen, Alex S. Hartlage, Luis Chiriboga, Kalpana Ghoshal, W. Ian Lipkin, Jens Bukh, Troels K. H. Scheel, Amit Kapoor, Charles M. Rice   +14 more
openaire   +3 more sources