Results 31 to 40 of about 16,038 (235)

Hepatitis C Virus Saint Petersburg Variant Detection With Machine Learning Methods. [PDF]

J Med Virol
ABSTRACT Hepatitis C virus infection is a significant global health concern, affecting millions worldwide. Although direct‐acting antivirals achieve over 90% success rate, treatment failures still occur, particularly when pan‐genotypic DAAs are unavailable, and drugs need to be chosen based on the present HCV genotype.
Arslan N, Reuter B, Buech J, Lengauer T, Obermeier M, Kaiser R, Pfeifer N.   +6 more
europepmc   +2 more sources

In Vitro Comparison of the Internal Ribosomal Entry Site Activity from Rodent Hepacivirus and Pegivirus and Construction of Pseudoparticles [PDF]

Advances in Virology, 2021
The 5′ untranslated region (5′ UTR) of rodent hepacivirus (RHV) and pegivirus (RPgV) contains sequence homology to the HCV type III internal ribosome entry sites (IRES).
Stuart Sims, Kevin Michaelsen, Sara Burkhard, Cornel Fraefel   +3 more
openalex   +2 more sources

A critique of the use of species and below-species taxonomic terms for viruses-time for change? [PDF]

Virus Evol
The International Committee for the Taxonomy of Viruses (ICTV) regulates assignment and names of virus species and higher taxa through its taxonomy proposal and ratification process.
Simmonds P.
europepmc   +3 more sources

The adjuvant effect of polymuramil, a NOD1 and NOD2 agonist, differs when immunizing mice of different inbred lines with nonstructural hepatitis C virus (Flaviviridae: <i>Hepacivirus</i>)proteins and is synergistically enhanced in combination with pyrogenalum, a TLR4 agonist

Voprosy virusologii, 2023
INTRODUCTION Hepatitis C is a liver disease with high chronicity, the cause of cirrhosis and hepatocarcinoma. The main obstacle to controlling hepatitis C is the lack of vaccines.
Ekaterina I. Lesnova, О. В. Масалова, Kristina Yu. Permyakova, N. A. Demidova, Vladimir T. Valuev-Elliston, Alexander V. Ivanov, Kushch Aa   +6 more
openalex   +3 more sources

Use of an Outbred Rat Hepacivirus Challenge Model for Design and Evaluation of Efficacy of Different Immunization Strategies for Hepatitis C Virus [PDF]

, 2019
BACKGROUND AND AIMS: The lack of immunocompetent small animal models for hepatitis C virus (HCV) has greatly hindered the development of effective vaccines.
Atcheson, E, Barnes, E, Bliss, CM, Chinnakannan, S, Dietrich, I, Heim, K, Hutchings, C, Jarvis, MA, Kapoor, A, Klenerman, P, Li, W, Nguyen, D, Sharpe, H, Simmonds, P   +13 more
core   +6 more sources

Ion-channel function and cross-species determinants in viral assembly of nonprimate hepacivirus p7 [PDF]

, 2016
Nonprimate hepacivirus (NPHV), the closest homolog of hepatitis C virus (HCV) described to date, has recently been discovered in horses. Even though the two viruses share a similar genomic organization, conservation of the encoded hepaciviral proteins ...
Abhinav Kumar, Alexander Bollenbach, Claire Scott, Eike Steinmann, François Penin, Gabrielle Vieyres, Global Burden of Disease Study Collaborators, Juliane Doerrbecker, M. S. Diamond, Nicole Zitzmann, Richard Foster, Richard J. P. Brown, Stephanie Pfaender, Stephanie Walter, Stephen Griffin, Thomas Pietschmann   +15 more
core   +3 more sources

Clinical Relevance and Drug Modulation of PPAR Signaling Pathway in Triple-Negative Breast Cancer: A Comprehensive Analysis. [PDF]

PPAR Res
Triple‐negative breast cancer (TNBC) is highly heterogeneous and poses a significant medical challenge due to limited treatment options and poor outcomes. Peroxisome proliferator‐activated receptors (PPARs) play a crucial role in regulating metabolism and cell fate. While the association between PPAR signal and human cancers has been a topic of concern,
Zhang Y, Liu Y, Zhang M, Li G, Zhu S, Xie K, Xiao B, Li L.   +7 more
europepmc   +2 more sources

Nonprimate Hepaciviruses in Domestic Horses, United Kingdom [PDF]

Emerging Infectious Diseases, 2012
Although the origin of hepatitis C virus infections in humans remains undetermined, a close homolog of this virus, termed canine hepacivirus (CHV) and found in respiratory secretions of dogs, provides evidence for a wider distribution of hepaciviruses in
Sinéad Lyons, Amit Kapoor, Colin Sharp, Bradley S. Schneider, Nathan D. Wolfe, Geoff Culshaw, Brendan Corcoran, Bruce C. McGorum, Peter Simmonds   +8 more
doaj   +3 more sources

Identification of a mimotope of a complex gp41 Human Immunodeficiency VIrus epitope related to a non-structural protein of Hepacivirus previously implicated in Kawasaki disease

bioRxiv
Background We have previously isolated a highly mutated VH1-02 antibody termed group C 76-Q13-6F5 (6F5) that targets a conformational epitope on gp41. 6F5 has the capacity to mediate Ab dependent cell cytotoxicity (ADCC).
Hakimuddin T. Sojar, Sarah Baron, Mark D. Hicar   +2 more
openalex   +3 more sources

miRNA independent hepacivirus variants suggest a strong evolutionary pressure to maintain miR-122 dependence [PDF]

, 2017
Hepatitis C virus (HCV) requires the liver specific micro-RNA (miRNA), miR-122, to replicate. This was considered unique among RNA viruses until recent discoveries of HCV-related hepaciviruses prompting the question of a more general miR-122 dependence ...
Antczak, Douglas F., Chung, Hachung, Divers, Thomas J., Echeverria, Natalia, Kapoor, Amit, Lipkin, W. Ian, Luna, Joseph M., Nishiuchi, Eiko, Ricardo-Lax, Inna, Rice, Charles M., Scheel, Troels K. H., Scull, Margaret A., Tennant, Bud C., Yu, Yingpu   +13 more
core   +7 more sources