Results 41 to 50 of about 44,632 (248)

Presence of a Novel Subtype of Bovine Hepacivirus in China and Expanded Classification of Bovine Hepacivirus Strains Worldwide into 7 Subtypes [PDF]

Viruses, 2019
The newest member of the Hepacivirus genus, bovine hepacivirus (BovHepV), was first identified in cattle in 2015 and is a novel hepacivirus C virus (HCV)-like virus.
Gang Lu, Jiajun Ou, Jiawei Zhao, Shoujun Li   +3 more
doaj   +3 more sources

Novel bovine hepacivirus in dairy cattle, China [PDF]

Emerging Microbes & Infections, 2018
Since it was first identified in 1989, Hepatitis C virus (HCV) has long been regarded as having one true natural host—humans1.
Gang Lu, Kun Jia, Xiaokun Ping, Ji Huang, Aimei Luo, Peixin Wu, Shoujun Li   +6 more
openalex   +3 more sources

Hallmarks of Hepatitis C Virus in Equine Hepacivirus [PDF]

Journal of Virology, 2014
ABSTRACT Equine hepacivirus (EHcV) has been identified as a closely related homologue of hepatitis C virus (HCV) in the United States, the United Kingdom, and Germany, but not in Asian countries. In this study, we genetically and serologically screened 31 serum samples obtained from Japanese-born domestic horses for EHcV ...
Tomohisa Tanaka, Hirotake Kasai, Atsuya Yamashita, Kaori Okuyama-Dobashi, Jun Yasumoto, Shinya Maekawa, Nobuyuki Enomoto, Toru Okamoto, Yoshiharu Matsuura, Masami Morimatsu, Noboru MANABE, Kazuhiko Ochiai, Kazuto YAMASHITA, Kohji Moriishi   +13 more
openalex   +3 more sources

HepacivirusInfection in Domestic Horses, Brazil, 2011–2013 [PDF]

Emerging Infectious Diseases, 2014
To the Editor: An estimated ≈150 million persons (3% of the world population) are chronically infected with hepatitis C virus (HCV). This virus is the prototype of the genus Hepacivirus and a major cause of liver cirrhosis and hepatocellular carcinoma around the world.
B. S. Gemaque, Alex Júnior Souza de Souza, Manoel do Carmo Pereira Soares, Andreza Pinheiro Malheiros, Andrea Lima Silva, Max Moreira Alves, Michele Soares Gomes‐Gouvêa, João Renato Rebello Pinho, Heriberto Ferreira de Figueiredo, Djacy Barbosa Ribeiro, Jonan Souza da Silva, Leopoldo Augusto Moraes, Ana Sílvia Sardinha Ribeiro, Washington Luiz Assunção Pereira   +13 more
openalex   +4 more sources

Equine hepacivirus persistent infection in a horse with chronic wasting

Transboundary and Emerging Diseases, 2017
Equine hepacivirus is the closest homologue of hepatitis C virus. Limited data on the clinical features of this infection are available. We report the identification of a horse with high-titre viremia by equine hepacivirus. Over a 15-month follow-up, the clinical signs and the viremic status persisted, suggesting a chronic evolution.
Gabriella Elia, Gianvito Lanave, Eleonora Lorusso, Antonio Parisi, Adriana Trotta, Raffaele Buono, Vito Martella, Nicola Decaro, Canio Buonavoglia   +8 more
openalex   +5 more sources

Mouse models of acute and chronic hepacivirus infection [PDF]

Science, 2017
New York City rats provide a gift to virologists Despite the development of curative drugs for hepatitis C virus (HCV) infection, global eradication of HCV will likely require a prophylactic vaccine. Progress toward a vaccine has been impeded by the absence of mouse models suitable for studying the immune response
Eva Billerbeck, Raphael Wolfisberg, Ulrik Fahnøe, Jing Xiao, Corrine Quirk, Joseph M. Luna, John M. Cullen, Alex S. Hartlage, Luis Chiriboga, Kalpana Ghoshal, W. Ian Lipkin, Jens Bukh, Troels K. H. Scheel, Amit Kapoor, Charles M. Rice   +14 more
openalex   +4 more sources

Protein Interactions during the Flavivirus and Hepacivirus Life Cycle [PDF]

Molecular & Cellular Proteomics, 2017
Protein-protein interactions govern biological functions in cells, in the extracellular milieu, and at the border between cells and extracellular space. Viruses are small intracellular parasites and thus rely on protein interactions to produce progeny inside host cells and to spread from cell to cell.
Gisa Gerold, Janina Bruening, Bettina Weigel, Thomas Pietschmann   +3 more
openalex   +4 more sources

Immune protection against reinfection with nonprimate hepacivirus [PDF]

Proceedings of the National Academy of Sciences, 2017
Significance Hepatitis C virus (HCV) displays a narrow species tropism severely hampering development of small animal models that are required for vaccine and pathogenesis studies in vivo. The recent discoveries of HCV-related hepaciviruses in diverse hosts offer new opportunities with respect to the development of an immunocompetent animal ...
Pfaender, Stephanie, Walter, Stephanie, Grabski, Elena, Todt, Daniel, Bruening, Janina, Romero-Brey, Inés, Gather, Theresa, Brown, Richard J P, Hahn, Kerstin, Puff, Christina, Pfankuche, Vanessa M, Hansmann, Florian, Postel, Alexander, Becher, Paul, Thiel, Volker, Kalinke, Ulrich, Wagner, Bettina, Bartenschlager, Ralf, Baumgärtner, Wolfgang, Feige, Karsten, Pietschmann, Thomas, Cavalleri, Jessika M V, Steinmann, Eike   +22 more
openaire   +3 more sources

Mutational Analysis of the Bovine Hepacivirus Internal Ribosome Entry Site [PDF]

Journal of Virology, 2018
Several members of the family Flaviviridae , including HCV, have adapted cap-independent translation strategies to overcome canonical eukaryotic translation pathways and use cis -acting RNA-elements, designated viral internal ribosome entry sites (IRES), to initiate translation.
Anna Lena Baron, Axel Schoeniger, Paul Becher, Christine Baechlein   +3 more
openalex   +3 more sources

Prevalence of equine hepacivirus infection in Mongolia

Virus Research, 2020
Equine hepacivirus (EHV) belongs to the hepacivirus A and is related to hepatitis C virus (HCV). This virus shows hepatic tropism and is known to chronically infect horses. EHV has been reported from various countries, but the prevalence in Mongolia, where large horse populations are pastured, remains unknown.
Tomoko, Date, Masaya, Sugiyama, Damdindorj, Lkhagvasuren, Takaji, Wakita, Tsendsuren, Oyunsuren, Masashi, Mizokami   +5 more
openaire   +2 more sources