Results 41 to 50 of about 43,714 (247)

Immune protection against reinfection with nonprimate hepacivirus [PDF]

Proceedings of the National Academy of Sciences, 2017
Significance Hepatitis C virus (HCV) displays a narrow species tropism severely hampering development of small animal models that are required for vaccine and pathogenesis studies in vivo. The recent discoveries of HCV-related hepaciviruses in diverse hosts offer new opportunities with respect to the development of an immunocompetent animal ...
Stephanie Pfaender, Stephanie Wälter, Elena Grabski, Daniel Tödt, Janina Bruening, Inés Romero‐Brey, Theresa Gather, Richard J. P. Brown, Kerstin Hahn, Christina Puff, Vanessa M. Pfankuche, Florian Hansmann, Alexander Postel, Paul Becher, Volker Thiel, Ulrich Kalinke, Bettina Wagner, Ralf Bartenschlager, Wolfgang Baumgärtner, Karsten Feige, Thomas Pietschmann, Jessika‐M. V. Cavalleri, Eike Steinmann   +22 more
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[Analysis of genetic polymorphisms and drug resistance mutations in the NS5 region of HCV genome (Flasuviricetes: Amarillovirales: Flaviviridae: Hepacivirus C) in samples obtained in 2022-2023 from HIV-infected treatment-naive residents of Altai Krai].

Voprosy virusologii
INTRODUCTION Altai Krai is a region with an unfavorable situation of HIV-1 and HCV infection, as well as HIV-1 and HCV coinfection. Due to this, it is necessary to study the HCV genetic variants and their drug resistance (DR) to direct-acting antivirals (
I. Lapovok, Arina Syrkina, A. Kirichenko, A. Shlykova, N. V. Lukyanenko, T. V. Safyanova, Arina E. Safronova, V. V. Shevchenko, D. Kireev   +8 more
semanticscholar   +2 more sources

NGS amplification panel HCV-seq for sequencing hepatitis C virus RNA (Flaviviridae: Hepacivirus).

Voprosy virusologii
INTRODUCTION Hepatitis C is a pressing global public health issue. The high variability of the hepatitis C virus (HCV) complicates its whole-genome sequencing; most studies sequence only specific regions of the genome.
M. D. Chanyshev, Anastasia S. Chernyshova, A. G. Glushchenko, A. A. Grishaeva, V. V. Makashova, Z.B. Ponezheva, K. Khafizov, V. Akimkin   +7 more
semanticscholar   +2 more sources

Mouse models of acute and chronic hepacivirus infection [PDF]

Science, 2017
New York City rats provide a gift to virologists Despite the development of curative drugs for hepatitis C virus (HCV) infection, global eradication of HCV will likely require a prophylactic vaccine. Progress toward a vaccine has been impeded by the absence of mouse models suitable for studying the immune response to HCV ...
Eva Billerbeck, Raphael Wolfisberg, Ulrik Fahnøe, Jing Xiao, Corrine Quirk, Joseph M. Luna, John M. Cullen, Alex S. Hartlage, Luis Chiriboga, Kalpana Ghoshal, W. Ian Lipkin, Jens Bukh, Troels K. H. Scheel, Amit Kapoor, Charles M. Rice   +14 more
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Mutational Analysis of the Bovine Hepacivirus Internal Ribosome Entry Site [PDF]

Journal of Virology, 2018
Several members of the family Flaviviridae , including HCV, have adapted cap-independent translation strategies to overcome canonical eukaryotic translation pathways and use cis -acting RNA-elements, designated viral internal ribosome entry sites (IRES), to initiate translation.
Anna Lena Baron, Axel Schoeniger, Paul Becher, Christine Baechlein   +3 more
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Hallmarks of Hepatitis C Virus in Equine Hepacivirus [PDF]

Journal of Virology, 2014
ABSTRACT Equine hepacivirus (EHcV) has been identified as a closely related homologue of hepatitis C virus (HCV) in the United States, the United Kingdom, and Germany, but not in Asian countries. In this study, we genetically and serologically screened 31 serum samples obtained from Japanese-born domestic horses for EHcV ...
Tomohisa Tanaka, Hirotake Kasai, Atsuya Yamashita, Kaori Okuyama-Dobashi, Jun Yasumoto, Shinya Maekawa, Nobuyuki Enomoto, Toru Okamoto, Yoshiharu Matsuura, Masami Morimatsu, Noboru MANABE, Kazuhiko Ochiai, Kazuto YAMASHITA, Kohji Moriishi   +13 more
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Prevalence of equine hepacivirus infection in Mongolia

Virus Research, 2020
Equine hepacivirus (EHV) belongs to the hepacivirus A and is related to hepatitis C virus (HCV). This virus shows hepatic tropism and is known to chronically infect horses. EHV has been reported from various countries, but the prevalence in Mongolia, where large horse populations are pastured, remains unknown.
Tsendsuren Oyunsuren, Tomoko Date, Masaya Sugiyama, Damdindorj Lkhagvasuren, Masashi Mizokami, Takaji Wakita   +5 more
openaire   +3 more sources

Acute and chronic infections with nonprimate hepacivirus in young horses [PDF]

Veterinary Research, 2016
The recently discovered nonprimate hepacivirus (NPHV) naturally infects horses and is the closest known homolog of hepatitis C virus to date. Within a follow-up study acute field infections were monitored in four young Thoroughbred horses until the ages of 12-13 months.
Gather, Theresa, Walter, Stephanie, Pfaender, Stephanie, Todt, Daniel, Feige, Karsten, Steinmann, Eike, Cavalleri, Jessika M V   +6 more
openaire   +5 more sources

Novel bovine hepacivirus in dairy cattle, China [PDF]

Emerging Microbes & Infections, 2018
Since it was first identified in 1989, Hepatitis C virus (HCV) has long been regarded as having one true natural host—humans1.
Shoujun Li, Ji Huang, Gang Lu, Xiaokun Ping, Peixin Wu, Aijian Luo, Kun Jia   +6 more
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Hepatitis C virus (Flaviviridae: Hepacivirus: Hepacivirus C): regulation of signaling reactions of innate immunity

Problems of Virology, 2021
Studying the regulation of signaling reactions of innate immunity by the hepatitis C virus (HCV) will help to reveal the causes of the transition of the acute form of the disease to a chronic course. The molecular mechanisms of activation by HCV RNA of innate immunity receptors TLR and RLR and signal transduction processes leading to the synthesis of ...
openaire   +4 more sources