Results 41 to 50 of about 20,741 (247)

Acute and chronic infections with nonprimate hepacivirus in young horses [PDF]

Veterinary Research, 2016
The recently discovered nonprimate hepacivirus (NPHV) naturally infects horses and is the closest known homolog of hepatitis C virus to date. Within a follow-up study acute field infections were monitored in four young Thoroughbred horses until the ages of 12-13 months.
Gather, Theresa, Walter, Stephanie, Pfaender, Stephanie, Todt, Daniel, Feige, Karsten, Steinmann, Eike, Cavalleri, Jessika M V   +6 more
openaire   +5 more sources

Discovery of Jogalong virus, a novel hepacivirus identified in a Culex annulirostris (Skuse) mosquito from the Kimberley region of Western Australia.

PLoS ONE, 2020
The discovery of hepaciviruses in non-human hosts has accelerated following the advancement of high-throughput sequencing technology. Hepaciviruses have now been described in reptiles, fish, birds, and an extensive array of mammals.
Simon H Williams, Avram Levy, Rachel A Yates, Nilusha Somaweera, Peter J Neville, Jay Nicholson, Michael D A Lindsay, John S Mackenzie, Komal Jain, Allison Imrie, David W Smith, W Ian Lipkin   +11 more
doaj   +1 more source

Novel bovine hepacivirus in dairy cattle, China [PDF]

Emerging Microbes & Infections, 2018
Since it was first identified in 1989, Hepatitis C virus (HCV) has long been regarded as having one true natural host—humans1.
Shoujun Li, Ji Huang, Gang Lu, Xiaokun Ping, Peixin Wu, Aijian Luo, Kun Jia   +6 more
openaire   +3 more sources

Histopathology of chronic hepatitis C in relation to virus genotype [PDF]

Vojnosanitetski Pregled, 2006
Background/aim: The natural history of hepatitis C virus (HCV) infection is variable and the factors determining the course of the illness are unclear. There are geographical variations in the distribution of different HCV genotypes, and some of them are
Simonović Jasmina, Dokić Ljubiša, Čutović Milisav, Tomanović Nada, Boričić Ivan, Prostran Milica, Nešić Zorica, Delić Dragan, Švirtlih Neda   +8 more
doaj   +1 more source

Phenotype and fate of liver-resident CD8 T cells during acute and chronic hepacivirus infection

PLoS Pathogens, 2023
Immune correlates of hepatitis C virus (HCV) clearance and control remain poorly defined due to the lack of an informative animal model. We recently described acute and chronic rodent HCV-like virus (RHV) infections in lab mice.
Piyush Dravid, S. Murthy, Zayed Attia, Cole Cassady, Rahul Chandra, Sheetal Trivedi, Ashish Vyas, John Gridly, Brantley Holland, Anuradha Kumari, A. Grakoui, John M Cullen, Christopher M Walker, Himanshu Sharma, Amit Kapoor   +14 more
semanticscholar   +1 more source

The adjuvant effect of polymuramil, a NOD1 and NOD2 agonist, differs when immunizing mice of different inbred lines with nonstructural hepatitis C virus (Flaviviridae: Hepacivirus)proteins and is synergistically enhanced in combination with pyrogenalum, a TLR4 agonist.

Voprosy virusologii, 2023
INTRODUCTION Hepatitis C is a liver disease with high chronicity, the cause of cirrhosis and hepatocarcinoma. The main obstacle to controlling hepatitis C is the lack of vaccines.
E. Lesnova, O. Masalova, K. Y. Permyakova, Natalia A. Demidova, V. Valuev-Elliston, Alexander V. Ivanov, Alla A. Kushch   +6 more
semanticscholar   +1 more source

The landscape of viral associations in human cancers [PDF]

, 2020
Here, as part of the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, for which whole-genome and—for a subset—whole-transcriptome sequencing data from 2,658 cancers across 38 tumor types was aggregated, we systematically investigated potential ...
Alawi, Malik, Borozan, Ivan, Brewer, Daniel S, Cooper, Colin S, Desai, Nikita, Eils, Roland, Ferretti, Vincent, Grundhoff, Adam, Iskar, Murat, Lichter, Peter, Moch, Holger, PCAWG Consortium, PCAWG Pathogens, Sültmann, Holger, Zapatka, Marc   +14 more
core   +3 more sources

Hepatitis C virus (Flaviviridae: Hepacivirus: Hepacivirus C): regulation of signaling reactions of innate immunity

Problems of Virology, 2021
Studying the regulation of signaling reactions of innate immunity by the hepatitis C virus (HCV) will help to reveal the causes of the transition of the acute form of the disease to a chronic course. The molecular mechanisms of activation by HCV RNA of innate immunity receptors TLR and RLR and signal transduction processes leading to the synthesis of ...
openaire   +4 more sources

Presence of a Novel Subtype of Bovine Hepacivirus in China and Expanded Classification of Bovine Hepacivirus Strains Worldwide into 7 Subtypes [PDF]

Viruses, 2019
The newest member of the Hepacivirus genus, bovine hepacivirus (BovHepV), was first identified in cattle in 2015 and is a novel hepacivirus C virus (HCV)-like virus. This virus has been detected in five countries so far and is classified into four subtypes.
Lu, Gang, Ou, Jiajun, Zhao, Jiawei, Li, Shoujun   +3 more
openaire   +3 more sources

Blocking Zika virus vertical transmission. [PDF]

, 2018
The outbreak of the Zika virus (ZIKV) has been associated with increased incidence of congenital malformations. Although recent efforts have focused on vaccine development, treatments for infected individuals are needed urgently. Sofosbuvir (SOF), an FDA-
Beltrão-Braga, Patricia CB, Corbett, Kevin D, Cugola, Fernanda R, Fernandes, Isabella R, Herai, Roberto H, Huang, Chun-Teng, Kolar, Matthew J, Macia, Angela, Mesci, Pinar, Momper, Jeremiah D, Montefusco, Sandro, Moore, Spencer M, Muotri, Alysson R, Pinto, Antonella, Rosenberg, Scott C, Russo, Fabiele B, Saghatelian, Alan, Sheets, Nicholas, Shiryaev, Sergey A, Shresta, Sujan, Siqueira-Neto, Jair L, Suarez, Nicole A, Tejwani, Leon, Terskikh, Alexey V   +23 more
core   +2 more sources