Results 41 to 50 of about 16,295 (220)

Design principles and applications of synthetic self‐replicating RNAs

WIREs RNA, Volume 14, Issue 6, November/December 2023., 2023
Self‐replicating RNAs (srRNAs) replicate enzymatically in the cytosol. Depending on their bespoke gene cargo, srRNAs can be transformed into powerful tools for various applications. Abstract With the advent of ever more sophisticated methods for the in vitro synthesis and the in vivo delivery of RNAs, synthetic mRNAs have gained substantial interest ...
Alexander Wagner, Hannes Mutschler
wiley   +1 more source

Hepatic immunopathology during occult hepacivirus re-infection [PDF]

Virology, 2017
Despite drug advances for Hepatitis C virus (HCV), re-infections remain prevalent in high-risk populations. Unfortunately, the role of preexisting viral immunity and how it modulates re-infection is unclear. GBV-B infection of common marmosets is a useful model to study tissue immune responses in hepacivirus infections, and in this study we re ...
Cordelia Manickam, Amanda J. Martinot, Rhianna Jones, Valerie Varner, R. Keith Reeves   +4 more
openalex   +4 more sources

Non-primate hepacivirus infection with apparent hepatitis in a horse — Short communication [PDF]

, 2014
Non-primate hepacivirus (NPHV) is a recently identified hepacivirus (family Flaviviridae) in dog and horse; however, the disease associations remain unknown.
Boros, Ákos, Maza, Norbert, Pankovics, Péter, Reuter, Gábor   +3 more
core   +1 more source

The genetics of immune and infection phenotypes in wild mice, Mus musculus domesticus

Molecular Ecology, Volume 32, Issue 15, Page 4242-4258, August 2023., 2023
Abstract Wild animals are under constant threat from a wide range of micro‐ and macroparasites in their environment. Animals make immune responses against parasites, and these are important in affecting the dynamics of parasite populations. Individual animals vary in their anti‐parasite immune responses.
Louise Cheynel, Luke Lazarou, Eleanor M. Riley, Mark Viney   +3 more
wiley   +1 more source

Hepatitis C subtyping assay failure in UK patients born in sub‐Saharan Africa: Implications for global treatment and elimination

Journal of Medical Virology, Volume 95, Issue 1, January 2023., 2023
Abstract Background and Aims The newly developed direct‐acting antivirals have revolutionized the treatment of chronic hepatitis C virus (HCV), with cure rates as high as 98% in some cohorts. Although genome sequencing has demonstrated that some subtypes of HCV naturally harbor drug resistance associated substitutions (RAS), these are often overlooked ...
Kazeem Adeboyejo, Barnabas J. King, Theocharis Tsoleridis, Alexander W. Tarr, John McLauchlan, William L. Irving, Jonathan K. Ball, C. Patrick McClure   +7 more
wiley   +1 more source

Blocking Zika virus vertical transmission. [PDF]

, 2018
The outbreak of the Zika virus (ZIKV) has been associated with increased incidence of congenital malformations. Although recent efforts have focused on vaccine development, treatments for infected individuals are needed urgently. Sofosbuvir (SOF), an FDA-
Beltrão-Braga, Patricia CB, Corbett, Kevin D, Cugola, Fernanda R, Fernandes, Isabella R, Herai, Roberto H, Huang, Chun-Teng, Kolar, Matthew J, Macia, Angela, Mesci, Pinar, Momper, Jeremiah D, Montefusco, Sandro, Moore, Spencer M, Muotri, Alysson R, Pinto, Antonella, Rosenberg, Scott C, Russo, Fabiele B, Saghatelian, Alan, Sheets, Nicholas, Shiryaev, Sergey A, Shresta, Sujan, Siqueira-Neto, Jair L, Suarez, Nicole A, Tejwani, Leon, Terskikh, Alexey V   +23 more
core   +2 more sources

Animal models to study hepatitis C virus infection [PDF]

, 2018
With more than 71 million chronically infected people, the hepatitis C virus (HCV) is a major global health concern. Although new direct acting antivirals have significantly improved the rate of HCV cure, high therapy cost, potential emergence of drug ...
Ahmed Atef Mesalam, Ahmed Atef Mesalam, Laura Collignon, Philip Meuleman, Rani Burm   +4 more
core   +3 more sources

Further Evidence for in Utero Transmission of Equine Hepacivirus to Foals [PDF]

Viruses, 2019
(1) Background: Equine hepacivirus (EqHV), also referred to as non-primate hepacivirus (NPHV), infects horses—and dogs in some instances—and is closely related to hepatitis C virus (HCV) that has infected up to 3% of the world’s human population, causing an epidemic of liver cirrhosis and cancer.
Pronost, Stéphane, Fortier, Christine, Marcillaud-Pitel, Christel, Tapprest, Jackie, Foursin, Marc, Saunier, Bertrand, Pitel, Pierre-Hugues, Paillot, Romain, Hue, Erika   +8 more
openaire   +5 more sources

Comparison of different in situ hybridization techniques for the detection of various RNA and DNA viruses [PDF]

, 2018
In situ hybridization (ISH) is a technique to determine potential correlations between viruses and lesions. The aim of the study was to compare ISH techniques for the detection of various viruses in different tissues.
Baechlein, C. (Christine), Baumgärtner, V. (Volkmar), Becher, P. (Paul), Bodewes, R. (Rogier), Habierski, A. (André), Hahn, K. (Kerstin), Hansmann, F. (Florian), Haverkamp, A.-K. (Ann-Kathrin), Osterhaus, A.D.M.E. (Albert), Pfaender, S. (Stephanie), Pfankuche, V.M. (Vanessa M.), Postel, A. (Alexander), Puff, C. (Christina), Steinmann, E. (Eike), Walter, S. (Stephanie)   +14 more
core   +2 more sources

Epidemiology of hepatitis C in Croatia in the European context [PDF]

, 2015
We analyzed prevalence, risk factors and hepatitis C virus (HCV) genotype distribution in different population groups in Croatia in the context of HCV epidemiology in Europe, with the aim to gather all existing information on HCV infection in Croatia ...
Barbić, Ljubo, Kaić, Bernard, Kučinar, Jasmina, Pandak, Nenad, Stevanović, Vladimir, Vilibić, Maja, Vilibić-Čavlek, Tatjana, Vraneš, Jasmina   +7 more
core   +1 more source