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Cellular Catabolism of Heparan Sulfate Proteoglycans.
Trends in Glycoscience and Glycotechnology, 1998 openaire +2 more sources
Change in the chondroitin/dermatan structure in distal lung tissue from COPD patients. [PDF]
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Functions of Cell Surface Heparan Sulfate Proteoglycans
Annual Review of Biochemistry, 1999▪ Abstract The heparan sulfate on the surface of all adherent cells modulates the actions of a large number of extracellular ligands. Members of both cell surface heparan sulfate proteoglycan families, the transmembrane syndecans and the glycosylphosphoinositide-linked glypicans, bind these ligands and enhance formation of their receptor-signaling ...
M, Bernfield +6 more
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Heparan Sulfate Proteoglycans in Diabetes
Seminars in Thrombosis and Hemostasis, 2021AbstractDiabetes is a complex disorder responsible for the mortality and morbidity of millions of individuals worldwide. Although many approaches have been used to understand and treat diabetes, the role of proteoglycans, in particular heparan sulfate proteoglycans (HSPGs), has only recently received attention.
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Development of Molecules Antagonizing Heparan Sulfate Proteoglycans
Seminars in Thrombosis and Hemostasis, 2021AbstractHeparan sulfate proteoglycans (HSPGs) occur in almost every tissue of the human body and consist of a protein core, with covalently attached glycosaminoglycan polysaccharide chains. These glycosaminoglycans are characterized by their polyanionic nature, due to sulfate and carboxyl groups, which are distributed along the chain.
Tanja, Gerlza +4 more
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Heparan Sulfate Proteoglycans in Amyloidosis
2010Amyloidosis is a generic term for a group of diseases characterized by deposits in different organ systems of insoluble materials composed mainly of distinct fibrillar proteins named amyloid. Besides amyloid, heparan sulfate proteoglycan (HSPG), is commonly found in most amyloid deposits, suggesting that HS/HSPG may be functionally involved in the ...
Xiao, Zhang, Jin-Ping, Li
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1999
Abstract Heparan sulfate proteoglycans (HSPGs)1 are highly charged macromolecules consisting of different core proteins with covalently linked heparan sulfate chains (HS) of varying monosaccharide sequence. These molecules are involved in a multitude of biologic processes including regulation of mesoderm induction, extension of neurites,
Nicholas W Shworak, Robert D Rosenberg
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Abstract Heparan sulfate proteoglycans (HSPGs)1 are highly charged macromolecules consisting of different core proteins with covalently linked heparan sulfate chains (HS) of varying monosaccharide sequence. These molecules are involved in a multitude of biologic processes including regulation of mesoderm induction, extension of neurites,
Nicholas W Shworak, Robert D Rosenberg
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Integral membrane heparan sulfate proteoglycans
The FASEB Journal, 1993Heparan sulfate is a regulatory polysaccharide. It modulates specific growth factor‐receptor interactions, accelerates the formation of specific proteinase‐proteinase inhibitor complexes, and mediates interactions of the cell surface with several enzymes and structural proteins.
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Alzheimer s disease and heparan sulfate proteoglycan
Frontiers in Bioscience, 1998Alzheimer's disease (AD) is a debilitating neurodegenerative disorder. Cardinal histopathologic changes of AD are neurofibrillary tangles (NFTs) and deposits of beta-amyloid protein (A-beta) in the form of neuritic plaques (NPs). Several different mutations found in patients with familial AD have been demonstrated to increase A-beta production ...
K, Fukuchi, M, Hart, L, Li
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Heparan Sulfate Proteoglycan-Mediated Polyamine Uptake
2011The polyamines are polycationic compounds essential for cellular proliferation and transformation. In addition to a well-defined biosynthesis pathway, polyamines are internalized into cells by as yet incompletely defined mechanisms. Numerous reports have shown that efficient polyamine uptake depends on the presence of polyanionic, cell surface ...
Johanna, Welch +3 more
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