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Heparan Sulfate Proteoglycan-Mediated Polyamine Uptake
2011The polyamines are polycationic compounds essential for cellular proliferation and transformation. In addition to a well-defined biosynthesis pathway, polyamines are internalized into cells by as yet incompletely defined mechanisms. Numerous reports have shown that efficient polyamine uptake depends on the presence of polyanionic, cell surface ...
Paulina Kucharzewska +3 more
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Heparan sulfate proteoglycans in healthy and diseased systems
WIREs Systems Biology and Medicine, 2011AbstractHeparin and heparan sulfate (HS) are glycosaminoglycans (GAGs) that are synthesized in the tissues and organs of mammals. They are synthesized and attached to a core protein as proteoglycans through serine–glycine concensus motifs along the core protein.
John M. Whitelock, James Melrose
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Synthesis of heparan sulfate proteoglycans by the isolated glomerulus
Biochemistry and Cell Biology, 1988Incorporation of [35S]sulfate into newly synthesized macromolecules was studied in the isolated rat glomerulus and found to be linear between 6 and 24 h. When whole glomeruli were treated under conditions that dissociate proteoglycan aggregates, >90% of incorporated label was extracted.
Marina Khatchatourian +1 more
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Heparan sulfate proteoglycans in Drosophila neuromuscular development
Biochimica et Biophysica Acta (BBA) - General Subjects, 2017Heparan sulfate proteoglycans (HSPGs) are glycoconjugates bearing heparan sulfate (HS) chains covalently attached to core proteins, which are ubiquitously distributed on the cell surface and in the extracellular matrix. HSPGs interact with a number of molecules mainly through HS chains, which play critical roles in diverse physiological and disease ...
Nobuaki Maeda, Keisuke Kamimura
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Functions of Heparan Sulfate Proteoglycans in Morphogenesis
2009Heparan sulfate proteoglycans (HSPG) are present ubiquitously on the cell surface and in the extracellular matrix including the basement membranes. There are two families of HSPGs in the cell surface, syndecans and glypicans. HSPGs in the extracellular matrix are mainly perlecan and agrin.
Hiroko Habuchi, Koji Kimata
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Disulfide-bonded aggregates of heparan sulfate proteoglycans
Biochemistry, 1984Heparan sulfate proteoglycans have been isolated from Swiss mouse 3T3 cells by using two nondegradative techniques: extraction with 4 M guanidine or 2.5% 1-butanol. These proteoglycans were separated from copurifying chondroitin sulfate proteoglycans by using ion-exchange chromatography on DEAE-cellulose in the presence of 2 M urea.
Linda J. Lowe-Krentz, John M. Keller
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Structure and Function of the Heparan Sulfate Proteoglycans [PDF]
, 1989 Heparan sulfate proteoglycans are a complex and heterogeneous family of macromolecules. They are composed of linear sulfated polysaccharide chains, the heparan sulfate moieties, that are covalently attached to protein. Their distribution is nearly ubiquitous.
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Autoantibodies to heparan sulfate proteoglycans
Autoimmunity Reviews, 2002Maryvonne Dueymes +4 more
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Heparan Sulfate Proteoglycans in Cancer Therapy
2011The polyanionic linear polysaccharide heparan sulfate specifically interacts with a multitude of extracellular ligands relevant to all steps of tumor progression. Heparan sulfate proteoglycans act as coreceptors for cytokine and chemokine signaling, modulating tumor cell growth and survival, chemotaxis, and angiogenesis.
Martin Götte +2 more
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BIOLOGICAL SIGNIFICANCE OF HEPARAN SULFATE PROTEOGLYCANS*
Annals of the New York Academy of Sciences, 1982P. Colburn, V. Buonassisi
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