Results 261 to 270 of about 40,174 (273)
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Heparan Sulfate Proteoglycan-Mediated Polyamine Uptake
2011The polyamines are polycationic compounds essential for cellular proliferation and transformation. In addition to a well-defined biosynthesis pathway, polyamines are internalized into cells by as yet incompletely defined mechanisms. Numerous reports have shown that efficient polyamine uptake depends on the presence of polyanionic, cell surface ...
Johanna, Welch +3 more
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Heparan sulfate proteoglycans recognize ghost Pick bodies
Neuroscience Letters, 1998An anti-heparan sulfate proteoglycan (HSPG) monoclonal antibody (3G10) recognized irregular round structures (IRSs) of various sizes adjacent to tau-positive intracellular Pick bodies (PBs) in the granular cell layer of the dentate gyrus and the superficial layers of the parahippocampal and other temporal gyri in Pick's disease.
T, Odawara +4 more
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Functions of Cell Surface Heparan Sulfate Proteoglycans
Annual Review of Biochemistry, 1999▪ Abstract The heparan sulfate on the surface of all adherent cells modulates the actions of a large number of extracellular ligands. Members of both cell surface heparan sulfate proteoglycan families, the transmembrane syndecans and the glycosylphosphoinositide-linked glypicans, bind these ligands and enhance formation of their receptor-signaling ...
M, Bernfield +6 more
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Heparan sulfate proteoglycans in Drosophila neuromuscular development
Biochimica et Biophysica Acta (BBA) - General Subjects, 2017Heparan sulfate proteoglycans (HSPGs) are glycoconjugates bearing heparan sulfate (HS) chains covalently attached to core proteins, which are ubiquitously distributed on the cell surface and in the extracellular matrix. HSPGs interact with a number of molecules mainly through HS chains, which play critical roles in diverse physiological and disease ...
Keisuke, Kamimura, Nobuaki, Maeda
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Heparan sulfate proteoglycans in extravasation
Frontiers in Bioscience, 2009Heparan sulfate proteoglycans (HSPGs) are glycoconjugates that are implicated in various biological processes including development, inflammation and repair, which is based on their capacity to bind and present several proteins via their carbohydrate side chains (glycosaminoglycans; GAGs). Well-known HSPGs include the family of syndecans and glypicans,
Celie, Johanna W. A. M. +2 more
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Disulfide-bonded aggregates of heparan sulfate proteoglycans
Biochemistry, 1984Heparan sulfate proteoglycans have been isolated from Swiss mouse 3T3 cells by using two nondegradative techniques: extraction with 4 M guanidine or 2.5% 1-butanol. These proteoglycans were separated from copurifying chondroitin sulfate proteoglycans by using ion-exchange chromatography on DEAE-cellulose in the presence of 2 M urea.
L J, Lowe-Krentz, J M, Keller
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Binding of Rat Thyroglobulin to Heparan Sulfate Proteoglycans
Thyroid, 2000We previously showed that rat thyroglobulin (Tg) is a heparin-binding protein and that heparin inhibits Tg binding to megalin (gp330), an endocytic Tg receptor found on the apical surface of thyrocytes. Cooperation between cell surface receptors and heparin-like molecules, namely heparan sulfate proteoglycans (HSPGs), can facilitate cell surface ...
MARINO', MICHELE +2 more
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Heparanases: endoglycosidases that degrade heparan sulfate proteoglycans
Glycobiology, 2001Heparanases are endoglycosidases that cleave the heparan sulfate glycosaminoglycans from proteoglycan core proteins and degrade them to small oligosaccharides. Inside cells, these enzymes are important for the normal catabolism of heparan sulfate proteoglycans (HSPGs), generating glycosaminoglycan fragments that are then transported to lysosomes and ...
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Heparan sulfate proteoglycans in invasion and metastasis
Seminars in Cell & Developmental Biology, 2001Because heparan sulfate proteoglycans mediate cell adhesion and control the activities of numerous growth and motility factors, they play a critical role in regulating the metastatic behavior of tumor cells. Due to their utilitarian nature, heparan sulfate proteoglycans may at times act as inhibitors of cell invasion and at other times as promoters of ...
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Autoantibodies to heparan sulfate proteoglycans
Autoimmunity Reviews, 2002Yves, Renaudineau +4 more
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