Syndecan-4 knockout leads to reduced extracellular transglutaminase-2 and protects against tubulointerstitial fibrosis [PDF]
, 2013 Transglutaminase type 2 (TG2) is an extracellular matrix crosslinking enzyme with a pivotal role in kidney fibrosis. The interaction of TG2 with the heparan sulfate proteoglycan syndecan-4 (Sdc4) regulates the cell surface trafficking, localization, and ...
Burhan, I +6 more
core +1 more source
Shotgun ion mobility mass spectrometry sequencing of heparan sulfate saccharides [PDF]
, 2020 Despite evident regulatory roles of heparan sulfate (HS) saccharides in numerous biological processes, definitive information on the bioactive sequences of these polymers is lacking, with only a handful of natural structures sequenced to date.
Grabarics, Márkó +9 more
core +1 more source
Basement membrane proteoglycans: modulators Par Excellence of cancer growth and angiogenesis. [PDF]
, 2009 Proteoglycans located in basement membranes, the nanostructures underling epithelial and endothelial layers, are unique in several respects. They are usually large, elongated molecules with a collage of domains that share structural and functional ...
Iozzo, Renato V +2 more
core +2 more sources
HSPG2 (heparan sulfate proteoglycan 2) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Review on HSPG2 (heparan sulfate proteoglycan 2), with data on DNA, on the protein encoded, and where the gene is implicated.
Farach-Carson, MC, Grindel, B
openaire +2 more sources
The endothelial glycocalyx prefers albumin for evoking shear stress-induced, nitric oxide-mediated coronary dilatation [PDF]
, 2007 Background: Shear stress induces coronary dilatation via production of nitric oxide ( NO). This should involve the endothelial glycocalyx ( EG). A greater effect was expected of albumin versus hydroxyethyl starch ( HES) perfusion, because albumin seals ...
Bernhard F. Becker +25 more
core +1 more source
Heparan Sulfate Proteoglycan Signaling in Tumor Microenvironment [PDF]
International Journal of Molecular Sciences, 2020 In the last few decades, heparan sulfate (HS) proteoglycans (HSPGs) have been an intriguing subject of study for their complex structural characteristics, their finely regulated biosynthetic machinery, and the wide range of functions they perform in living organisms from development to adulthood.
De Pasquale, Valeria +1 more
openaire +3 more sources
RNA-Seq identifies SPGs as a ventral skeletal patterning cue in sea urchins [PDF]
, 2016 The sea urchin larval skeleton offers a simple model for formation of developmental patterns. The calcium carbonate skeleton is secreted by primary mesenchyme cells (PMCs) in response to largely unknown patterning cues expressed by the ectoderm.
Bardot, Evan +26 more
core +1 more source
Frontiers in Immunology, 2020 Sexually transmitted Hepatitis C virus (HCV) infections and high reinfections are a major concern amongst men who have sex with men (MSM) living with HIV-1 and HIV-negative MSM.
Bernadien M. Nijmeijer +8 more
doaj +1 more source
Glycan Sulfation Modulates Dendritic Cell Biology and Tumor Growth
Neoplasia: An International Journal for Oncology Research, 2016 In cancer, proteoglycans have been found to play roles in facilitating the actions of growth factors, and effecting matrix invasion and remodeling. However, little is known regarding the genetic and functional importance of glycan chains displayed by ...
Roland El Ghazal +7 more
doaj +1 more source
Heparan sulfate proteoglycans undergo differential expression alterations in left sided colorectal cancer, depending on their metastatic character [PDF]
, 2018 Background Heparan sulfate proteoglycans (HSPGs) are complex molecules which play a role in the invasion and growth and metastatic properties of cancerous cells.
Castañón de la Torre, Sonia +6 more
core +2 more sources