Results 41 to 50 of about 20,897 (221)

Iron‐Catalyzed Highly Stereospecific Glycosylation with Glycal Epoxides

Angewandte Chemie, EarlyView.
We report an iron‐catalyzed, highly stereospecific glycosylation method with glycal epoxides, which is effective for a broad range of substrates, including previously challenging, sterically hindered secondary acceptors and glucuronic ester epoxide donors.
Xiao‐Wen Zhang, Le Yin, Dakang Zhang, Zixiang Jiang, Pinzhi Wang, Hao Xu   +5 more
wiley   +2 more sources

Classification and Molecular Functions of Heparan Sulfate Proteoglycans and Their Molecular Mechanisms with the Receptor

Biologics
Heparan sulfate proteoglycans are highly glycosylated proteins in which heparan sulfate, a glycosaminoglycan sugar chain, is an acidic sugar chain consisting of a repeating disaccharide structure of glucuronic acid and N-acetylglucosamine is locally ...
Yasunari Matsuzaka, Ryu Yashiro
doaj   +1 more source

Regulation of FGF10 Signaling in Development and Disease

Frontiers in Genetics, 2018
Fibroblast Growth Factor 10 (FGF10) is a multifunctional mesenchymal-epithelial signaling growth factor, which is essential for multi-organ development and tissue homeostasis in adults.
Joanne Watson, Joanne Watson, Chiara Francavilla   +2 more
doaj   +1 more source

Cell adhesion and signaling on the fibronectin 1^st type III repeat; requisite roles for cell surface proteoglycans and integrins

BMC Cell Biology, 2001
Background The first type III repeat of fibronectin is known to be involved in fibronectin matrix assembly, and recombinant proteins from this type III repeat can inhibit cell proliferation, tumor metastasis and angiogenesis. We have analyzed the way rat
Morla Alex O, Mercurius Kwesi O
doaj   +1 more source

Proteoglycans act as cellular hepatitis delta virus attachment receptors. [PDF]

PLoS ONE, 2013
The hepatitis delta virus (HDV) is a small, defective RNA virus that requires the presence of the hepatitis B virus (HBV) for its life cycle. Worldwide more than 15 million people are co-infected with HBV and HDV.
Oscar Lamas Longarela, Tobias T Schmidt, Katrin Schöneweis, Raffaella Romeo, Heiner Wedemeyer, Stephan Urban, Andreas Schulze   +6 more
doaj   +1 more source

Developmental roles of heparan sulfate proteoglycans in Drosophila [PDF]

Glycoconjugate Journal, 2002
The formation of complex patterns in multi-cellular organisms is regulated by a number of signaling pathways. In particular, the Wnt and Hedgehog (Hh) pathways have been identified as critical organizers of pattern in many tissues. Although extensive biochemical and genetic studies have elucidated the central components of the signal transduction ...
Xinhua Lin, Norbert Perrimon
openaire   +3 more sources

Evolutionary dynamics of heparan sulfate utilization by SARS-CoV-2

mBio
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variants have acquired enhanced infectivity compared to earlier variants. To elucidate the underlying molecular mechanisms, we conducted CRISPR library screening to identify cell ...
Shuhei Higuchi, Yafei Liu, Jun Shimizu, Chikako Ono, Yumi Itoh, Wataru Nakai, Hui Jin, Kazuki Kishida, Kazuo Takayama, Toru Okamoto, Yoshiko Murakami, Taroh Kinoshita, Yoshiharu Matsuura, Tatsuo Shioda, Hisashi Arase   +14 more
doaj   +1 more source

MASP-2 Is a Heparin-Binding Protease; Identification of Blocking Oligosaccharides

Frontiers in Immunology, 2020
It is well-known that heparin and other glycosaminoglycans (GAGs) inhibit complement activation. It is however not known whether fractionation and/or modification of GAGs might deliver pathway-specific inhibition of the complement system.
Ditmer T. Talsma, Felix Poppelaars, Wendy Dam, Anita H. Meter-Arkema, Romain R. Vivès, Peter Gál, Geert-Jan Boons, Geert-Jan Boons, Pradeep Chopra, Annamaria Naggi, Marc A. Seelen, Stephan P. Berger, Mohamed R. Daha, Coen A. Stegeman, Jacob van den Born, the COMBAT Consortium   +15 more
doaj   +1 more source

Microbial Subversion of Heparan Sulfate Proteoglycans

Molecules and Cells, 2008
The interactions between the host and microbial pathogen largely dictate the onset, progression, and outcome of infectious diseases. Pathogens subvert host components to promote their pathogenesis and, among these, cell surface heparan sulfate proteoglycans are exploited by many pathogens for their initial attachment and subsequent cellular entry.
Ye, Chen, Martin, Götte, Jian, Liu, Pyong Woo, Park   +3 more
openaire   +2 more sources

Functional Requirements for Heparan Sulfate Biosynthesis in Morphogenesis and Nervous System Development in C. elegans. [PDF]

PLoS Genetics, 2017
The regulation of cell migration is essential to animal development and physiology. Heparan sulfate proteoglycans shape the interactions of morphogens and guidance cues with their respective receptors to elicit appropriate cellular responses.
Cassandra R Blanchette, Andrea Thackeray, Paola N Perrat, Siegfried Hekimi, Claire Y Bénard   +4 more
doaj   +1 more source