Results 41 to 50 of about 17,555 (155)

TLR7 Mediates HIV‐1 Tat‐Induced Cellular Senescence in Human Astrocytes

Aging Cell, EarlyView.
Once internalized into endolysosomes, HIV‐1 Tat interacts and activates TLR7, causing endolysosome damage. Such interaction between HIV‐1 Tat and TLR7 also leads to a senescence‐like phenotype in astrocytes, including cell cycle arrest, elevated levels of p21 and p16 proteins, increased SA‐β‐gal activity, and enhanced secretion of SASP factors ...
Neda Rezagholizadeh, Gaurav Datta, Wendie A. Hasler, Erica C. Nguon, Elise V. Smokey, Xuesong Chen   +5 more
wiley   +1 more source

A Comprehensive Multiomics Signature of Doxorubicin‐Induced Cellular Senescence in the Postmenopausal Human Ovary

Aging Cell, EarlyView.
Explants of human postmenopausal ovarian cortex and medulla were treated with doxorubicin for 24 h followed by culture for up to 10 days in doxorubicin‐free medium. Single nuclei sequencing and proteomics revealed an unbiased signature of ovarian senescence driven by epithelial cells in the cortex and stromal cells in the cortex and medulla ...
Pooja Raj Devrukhkar, Mark A. Watson, Bikem Soygur, Fei Wu, Joanna Bons, Hannah Anvari, Tomiris Atazhanova, Nicolas Martin, Tommy Tran, Kevin Schneider, Jacob P. Rose, Daniel Winer, Elisheva Shanes, Mary Ellen G. Pavone, Judith Campisi, David Furman, Simon Melov, Birgit Schilling, Francesca E. Duncan   +18 more
wiley   +1 more source

Heparan sulfate proteoglycans present PCSK9 to the LDL receptor. [PDF]

Nat Commun, 2017
AbstractCoronary artery disease is the main cause of death worldwide and accelerated by increased plasma levels of cholesterol-rich low-density lipoprotein particles (LDL). Circulating PCSK9 contributes to coronary artery disease by inducing lysosomal degradation of the LDL receptor (LDLR) in the liver and thereby reducing LDL clearance.
Gustafsen C, Olsen D, Vilstrup J, Lund S, Reinhardt A, Wellner N, Larsen T, Andersen CBF, Weyer K, Li JP, Seeberger PH, Thirup S, Madsen P, Glerup S.   +13 more
europepmc   +8 more sources

Role of IL‐34 in Tumors and Its Application to Regulate Inflammation

Cancer Science, Volume 116, Issue 5, Page 1164-1170, May 2025.
IL‐34 and its receptors. ABSTRACT Interleukin (IL)‐34 is a relatively recently discovered cytokine which binds to colony‐stimulating factor‐1 receptor (CSF‐1R). So far, there has been no clear explanation as to why CSF‐1R requires two ligands. While CSF‐1 is ubiquitously expressed, the expression of IL‐34 is relatively restricted.
Yuichi Igarashi, Ken‐ichiro Seino
wiley   +1 more source

Organoid Models to Study Human Infectious Diseases

Cell Proliferation, EarlyView.
Our manuscript reviews the role of organoids as models for studying human infectious diseases, highlighting their irreplaceable contributions to drug testing and vaccine development for significant infectious diseases including HIV, ZIKV, SARS‐CoV‐2 and MPXV.
Sijing Zhu, Dan Chen, Xinzhi Yang, Liuliu Yang, Yuling Han   +4 more
wiley   +1 more source

Exercise Delays Brain Ageing Through Muscle‐Brain Crosstalk

Cell Proliferation, EarlyView.
This graphical abstract illustrates the reciprocal crosstalk between the brain and peripheral organs, highlighting the profound impact of exercise on brain health through systemic interactions. It underscores how exercise influences the brain via signals from various organs and, conversely, how the brain modulates functions of peripheral organs.
Shirin Pourteymour, Rakesh Kumar Majhi, Frode A. Norheim, Christian A. Drevon   +3 more
wiley   +1 more source

Intelligent Manufacturing for Osteoarthritis Organoids

Cell Proliferation, EarlyView.
Overall schematic of intelligent manufacturing in osteoarthritis organoids. Broad overview of the article's structure, outlining the progression from fundamental joint anatomy and OA pathogenesis to organoid construction and, ultimately, to intelligent manufacturing and future prospects.
Xukun Lyu, Jian Wang, Jiacan Su
wiley   +1 more source

Developments in albuminuria testing: A key biomarker for detection, prognosis and surveillance of kidney and cardiovascular disease—A practical update for clinicians

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Albuminuria, the abnormal presence of albumin in urine, is a key marker of kidney damage and a strong predictor of kidney and cardiovascular outcomes. Its clinical significance has evolved from early historical observations to its current role in chronic kidney disease (CKD) detection, risk stratification and treatment monitoring.
Jelle M. Beernink, Dominique van Mil, Gozewijn D. Laverman, Hiddo J. L. Heerspink, Ron T. Gansevoort   +4 more
wiley   +1 more source

Osteochondrosis in horses: An overview of genetic and other factors

Equine Veterinary Journal, EarlyView.
Abstract Osteochondrosis (OC) is a frequent manifestation of developmental orthopaedic disease, and its severe clinical presentation is known as OC dissecans (OCD). OC is defined as a disruption of the endochondral ossification process in the epiphyseal cartilage, and this disease has been reported in different mammalian species, including humans, dogs,
Lola Martinez‐Saez, Pablo J. Marín‐García, M. Lola Llobat   +2 more
wiley   +1 more source

Enhancing therapeutic efficacy through degradation of endogenous extracellular matrix in primary breast tumor spheroids

The FEBS Journal, EarlyView.
Solid tumors have a complex extracellular matrix (ECM) that can significantly affect tumor behavior and treatment response. Understanding the role of the ECM is therefore critical for understanding tumor biology and improving therapeutic responses. In this study, we isolated primary cells from a DMBA‐induced tumor mass to generate three‐dimensional ...
Alessandra Lo Cicero, Simona Campora, Gabriele Lo Buglio, Paolo Cinà, Margot Lo Pinto, Simone Dario Scilabra, Giulio Ghersi   +6 more
wiley   +1 more source