Results 61 to 70 of about 17,555 (155)

The causative role of amyloidosis in the cardiac complications of Alzheimer's disease: a comprehensive systematic review

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic illustration of the bidirectional causative link between cerebral amyloid‐beta (Aβ) angiopathy and cardiovascular disease in Alzheimer's disease (AD). Common cardiovascular risk factors like microvascular thrombosis, diabetes, atrial fibrillation, hypertension and atherosclerosis lead to cerebral hypoperfusion and ...
Samuel Parker, James Andrew, Mastitskaya Svetlana   +2 more
wiley   +1 more source

Bioinformatics analysis identifies heparan sulfate proteoglycans acting as different progress subtypes of biliary atresia. [PDF]

Front Pediatr, 2023
Ding Z, Song W, Zhu W, Xie H, Zhu Z, Tang W.   +5 more
europepmc   +1 more source

Hippocampal Astrocyte Morphology Follows an Unexpected Trajectory With Age in a Transgenic Rodent Model of Tauopathy

Glia, Volume 73, Issue 7, Page 1502-1519, July 2025.
Main Points During ageing, the complexity of astrocyte morphology peaks at adulthood then declines. In Tau22 transgenic mice, tau accumulates in astrocytes with age. Tauopathy is associated with simpler initial morphology followed by the appearance of a cluster of complex cells at advanced stage.
Emma Augustin, Tatiana Vinasco‐Sandoval, Miriam Riquelme‐Perez, Damien Plassard, Mylène Gaudin, Gwenaëlle Aurégan, Julien Mitja, Sueva Bernier, Charlène Joséphine, Fanny Petit, Caroline Jan, Anne‐Sophie Hérard, Marie‐Claude Gaillard, Agathe Launay, Emilie Faivre, Luc Buée, Anne‐Laurence Boutillier, David Blum, Alexis‐Pierre Bemelmans, Gilles Bonvento, Karine Cambon   +20 more
wiley   +1 more source

The 3-O sulfation of heparan sulfate proteoglycans contributes to the cellular internalization of tau aggregates. [PDF]

BMC Mol Cell Biol, 2022
Ferreira A, Royaux I, Liu J, Wang Z, Su G, Moechars D, Callewaert N, De Muynck L.   +7 more
europepmc   +1 more source

It's Time to Unite: Diversity and Coordination of Thymic Stromal Cells for T Cell Selection and Organ Integrity

Immunological Reviews, Volume 332, Issue 1, July 2025.
ABSTRACT The thymus is a primary lymphoid organ for generating a diverse yet self‐tolerant T cell repertoire. Among the thymic stromal cells that create the thymic microenvironment, thymic epithelial cells (TECs) have received the most attention because of their distinctive functions in the repertoire selection of T cells. Other types of thymic stromal
Ryunosuke Muro, Takeshi Nitta
wiley   +1 more source

Influence of Heparan Sulfate Proteoglycans and Factor X on species D Human Adenovirus Uptake and Transduction. [PDF]

Viruses, 2022
Schröer K, Alshawabkeh M, Schellhorn S, Bronder K, Zhang W, Ehrhardt A.   +5 more
europepmc   +1 more source

Association of Synovial Innate Immune Exhaustion With Worse Pain in Knee Osteoarthritis

Arthritis &Rheumatology, Volume 77, Issue 6, Page 664-676, June 2025.
Objective Uncontrolled pain remains a major clinical challenge in the management of knee osteoarthritis (OA), the most common disabling joint disease. Worse pain is associated with synovial innate immune cell infiltration (synovitis), but the role of innate immune‐regulatory cells in pain is unknown. Our objective was to identify synovial innate immune
Holly T. Philpott, Trevor B. Birmingham, Garth Blackler, J. Daniel Klapak, Alexander J. Knights, Easton C. Farrell, Benoit Fiset, Logan A. Walsh, J. Robert Giffin, Edward M. Vasarhelyi, Steven J. MacDonald, Brent A. Lanting, Tristan Maerz, C. Thomas Appleton, on behalf of the WOREO Knee Study Group   +14 more
wiley   +1 more source

Persistent Activation of Sphingosine‐1‐Phosphate Receptor 1 by Phytosphingosine‐3,4‐Cyclic Phosphate Ameliorates Sepsis by Inhibiting Hyperinflammation and Vascular Hyperpermeability

MedComm, Volume 6, Issue 6, June 2025.
Phytosphingosine‐3,4‐cyclic phosphate was synthetized from phytosphingosine. Phytosphingosine‐3,4‐cyclic phosphate had a strong therapeutic effect on sepsis through sphingosine‐1‐phosphate receptor 1 (S1P1)‐mediated inhibition of hyperinflammation in macrophages and vascular hyperpermeability in endothelium via SIRT1 upregulation.
Suhong Duan, Seung‐Gook Kim, Jiaying Bao, Hyung‐Jin Lim, Joon Woo Kim, Sung‐Il Yoon, Young Jun Park, Sanuk Yun, Kye‐Seong Kim, Hwa‐Ryung Song, Myeong Jun Choi, Myung‐Kwan Han   +11 more
wiley   +1 more source

An Atlas of Heparan Sulfate Proteoglycans in the Postnatal Rat Lens. [PDF]

Invest Ophthalmol Vis Sci, 2021
Wishart TFL, Lovicu FJ.
europepmc   +1 more source

Assessing the Impact of Partial Decellularization on Tracheal Chondrocytes and Extracellular Matrix in Airway Reconstruction

Otolaryngology–Head and Neck Surgery, Volume 172, Issue 6, Page 2026-2037, June 2025.
Abstract Objective Partially decellularized tracheal grafts (PDTG) are potential candidates for tracheal replacement as they support neotissue formation without stenosis or rejection. However, the effects of partial decellularization (PD) on extracellular matrix (ECM) and chondrocytes are not currently understood, limiting PDTG translatability for ...
Lumei Liu, Jazmin Calyeca, Sayali Dharmadhikari, Zheng Hong Tan, Jane Yu, Ada C. Sher, Melwan Izem, Sovannarath Pong, Kimberly M. Shontz, Tendy Chiang   +9 more
wiley   +1 more source