Results 111 to 120 of about 11,910 (223)

Role of the Blood-Brain Barrier in the Formation of Brain Metastases [PDF]

, 2013
The majority of brain metastases originate from lung cancer, breast cancer and malignant melanoma. In order to reach the brain, parenchyma metastatic cells have to transmigrate through the endothelial cell layer of brain capillaries, which forms the ...
Abbott, Ahn, Anfuso, Armulik, Aucoin, Aurrand-Lions, Balda, Barnhill, Bauer, Bos, Brayton, Brightman, Cangara, Carman, Chen, Cohen, Colone, Coussens, Cruz-Munoz, Csilla Fazakas, Cuevas, Daneman, Davies, Dejana, Deli, Denes, Douglas, Duenisch, Fabian, Fan, Farkas, Fidler, Fidler, Furuse, Furuse, Gay, Grinberg-Rashi, Gumbiner, Haskins, Hellstrom, Heon, Hicks, Holland, Hu, Hynes, Ilan, Imola Wilhelm, Inoko, István Krizbai, Izraely, Judit Molnár, János Haskó, Kacem, Khuon, Kienast, Kikuchi, Kim, Kim, Klein, Klein, Konstantopoulos, Krizbai, Krizbai, Krizbai, Krizbai, Krizbai, Lacaz-Vieira, Langer, Langley, Lecht, Lee, Lee, Lee, Li, Lin, Linger, Lockman, Longo, Lorger, Lorger, Lu, Maraveyas, Marchetti, Marchetti, Martin-Padura, Mendes, Mendes, Menter, Mierke, Neuwelt, Nguyen, Nicolson, Nishioku, Nitta, Ohtsuki, Oldendorf, Onodera, Ouban, Paku, Palmieri, Palmieri, Pardridge, Paspalas, Peng, Pestalozzi, Piontek, Platta, Qi, Qi, Reijerkerk, Ridgway, Rolland, Roy, Sahai, Sanz-Moreno, Savettieri, Seike, Shabani, Shimizu, Shintani, Sierra, Sims, Sipos, Stark, Stevenson, Stolp, Takeda, Takenaga, Tester, Tilling, Traweger, Wen, Wilhelm, Wilhelm, Wolburg, Wolf, Wong, Wu, Xie, Yoo, Yoshimasu, Zeljko, Zhang, Zhang, Zohrabian   +144 more
core   +2 more sources

Heparanase affects food intake and regulates energy balance in mice.

PLoS ONE, 2012
Mutation of the melanocortin-receptor 4 (MC4R) is the most frequent cause of severe obesity in humans. Binding of agouti-related peptide (AgRP) to MC4R involves the co-receptor syndecan-3, a heparan sulfate proteoglycan.
Linda Karlsson-Lindahl, Linnéa Schmidt, David Haage, Caroline Hansson, Magdalena Taube, Emil Egecioglu, Ying-xia Tan, Therese Admyre, John-Olov Jansson, Israel Vlodavsky, Jin-Ping Li, Ulf Lindahl, Suzanne L Dickson   +12 more
doaj   +1 more source

Detection of Syndecan-1 and Heparanase-1 Genes in Esophageal Carcinoma by Quantitative RT-PCR

Cancer Biology & Medicine, 2010
OBJECTIVE To quantitatively explore the expression of Syndecan-1 and heparanase-1 in esophageal cancer tissue as well as their relationship with the clinicopathological factors, in order to evaluate their roles in tumor invasion and metastasis.METHODS
Jun-li SI, Yu-qin QI, Jing-yuan CUI
doaj   +1 more source

The Mechanisms of Chondroitin Sulphate Lyases Treatment in Promotion of Axonal Growth [PDF]

, 2012
Poster PresentationIn Injured nerves, chondroitin sulphate (CS) is upregulated forming barriers with astrocytes/fibroblasts and other extracellular matrix molecules, and thereby hampering nerve regeneration.
Chan, YS, Shum, DKY, Tam, KW
core  

Plasma heparanase is associated with blood glucose levels but not urinary microalbumin excretion in type 2 diabetic nephropathy at the early stage

Renal Failure, 2017
Aim: To explore the possible correlations between plasma heparanase and albuminuria, glucose and lipid metabolism in the type 2 diabetic nephropathy patients at the early stage.Methods: One hundred and forty patients with type 2 diabetic nephropathy at ...
Yue Zhao, Jingshun Liu, Shichao Ten, Jisheng Zhang, Yanggang Yuan, Jiangyi Yu, Xiaofei An   +6 more
doaj   +1 more source

The Heparanase Inhibitor PG545 Attenuates Colon Cancer Initiation and Growth, Associating with Increased p21 Expression

Neoplasia: An International Journal for Oncology Research, 2017
Heparanase activity is highly implicated in cellular invasion and tumor metastasis, a consequence of cleavage of heparan sulfate and remodeling of the extracellular matrix underlying epithelial and endothelial cells.
Preeti Singh, Alexandra Blatt, Sari Feld, Yaniv Zohar, Esraa Saadi, Liza Barki-Harrington, Edward Hammond, Neta Ilan, Israel Vlodavsky, Yehuda Chowers, Elizabeth Half   +10 more
doaj   +1 more source

Regulatory role of proheparanase with peri-synaptic heparan sulfate proteoglycan and AMPA-type glutamate receptor in synaptic plasticity [PDF]

, 2012
Poster Presentation: P59AMPA-type glutamate receptors (AMPAR) govern excitatory synaptic transmission. Perineuronal heparan sulfates (HS) have been implicated in controlling the open-state of AMPAR.
Cham, WC, Chan, YS, Lam, YL, Ma, CW, Shum, DKY   +4 more
core  

Human Heparanase [PDF]

Journal of Biological Chemistry, 1999
Minako Toyoshima, Motowo Nakajima
openaire   +1 more source

Role of heparanase on hepatic uptake of intestinal derived lipoprotein and fatty streak formation in mice.

PLoS ONE, 2011
BackgroundHeparanase modulates the level of heparan sulfate proteoglycans (HSPGs) which have an important role in multiple cellular processes. Recent studies indicate that HSPGs have an important function in hepatic lipoprotein handling and processes ...
David Planer, Shulamit Metzger, Eyal Zcharia, Isaiah D Wexler, Israel Vlodavsky, Tova Chajek-Shaul   +5 more
doaj   +1 more source

Heparan Sulfate: A Ubiquitous Glycosaminoglycan with Multiple Roles in Immunity

, 2015
Heparan sulfate (HS) is a highly acidic linear polysaccharide with a very variable structure. It is ubiquitously expressed on cell surfaces and in the extracellular matrix and basement membrane of mammalian tissues.
Parish, Christopher, Simon Davis, David Anak   +1 more
core   +1 more source