Results 91 to 100 of about 11,910 (223)

Global Research Trends on Endothelial Glycocalyx in Sepsis: A Bibliometric Analysis

BioMed Research International, Volume 2026, Issue 1, 2026.
Background Sepsis remains a major global health challenge, with glycocalyx dysfunction playing an important role in its pathogenesis. Recent research highlights EG degradation as a key contributor to vascular permeability, inflammation, and organ failure. Despite growing interest, a comprehensive bibliometric analysis of global research trends on EG in
Kamila R. Daniyarova, Zhanslu N. Sarkulova, Amin Tamadon, Ainur B. Tokshilykova, Marat N. Sarkulov, Botagoz M. Kalieva, Nadiar M. Mussin, Ramazon Safarzoda Sharoffidin, Baisakhi Banerjee   +8 more
wiley   +1 more source

Heparanase and Coagulation–New Insights [PDF]

Rambam Maimonides Medical Journal, 2014
Heparanase, a β-D-endoglucuronidase abundant in platelets that was discovered 30 years ago, is an enzyme that cleaves heparan sulfate side chains on the cell surface and in the extracellular matrix. It was later recognized as being a pro-inflammatory and pro-metastatic protein.
openaire   +3 more sources

Assessment of Heparanase-Mediated Angiogenesis Using Microvascular Endothelial Cells: Identification of λ-Carrageenan Derivative as a Potent Anti Angiogenic Agent

Marine Drugs, 2017
Heparanase is overexpressed by tumor cells and degrades the extracellular matrix proteoglycans through cleavage of heparan sulfates (HS), allowing pro-angiogenic factor release and thus playing a key role in tumor angiogenesis and metastasis.
Nicolas Poupard, Pamela Badarou, Fabienne Fasani, Hugo Groult, Nicolas Bridiau, Frédéric Sannier, Stéphanie Bordenave-Juchereau, Claudine Kieda, Jean-Marie Piot, Catherine Grillon, Ingrid Fruitier-Arnaudin, Thierry Maugard   +11 more
doaj   +1 more source

Extracellular matrix in hematopoiesis and hematologic malignancies [PDF]

, 2008
The extracellular matrix (ECM) is a complex structure composed of collagens, proteoglycans, glycosaminoglycans and adhesive glycoproteins. Interactions between the cells and the ECM are crucial to determine cell behavior, such as growth, death ...
Dreyfuss, Juliana Luporini, Oliveira, José Salvador Rodrigues de   +1 more
core   +3 more sources

From a Shared Stress to Cell‐Type‐Specific Responses: The Heterogeneous Mechanisms of High Glucose‐Induced Cellular Senescence in Diabetic Kidney Disease

Journal of Diabetes Research, Volume 2026, Issue 1, 2026.
Diabetic kidney disease (DKD) is a severe microvascular complication of diabetes characterized by complex pathogenesis in which renal cellular senescence is a critical pathological element. Traditionally, hyperglycemia has been regarded as a uniform stressor inducing cellular senescence; however, significant heterogeneity exists in different renal cell
Jing Wang, Tian Liu, Kai Zhu, Ni Lin, Qi Wang, Beijia Xu, Xiaomin Wang, Hannah Wesley   +7 more
wiley   +1 more source

Heparanase and Type 1 Diabetes

, 2020
Type 1 diabetes (T1D) results from autoimmune destruction of insulin-producing beta cells in pancreatic islets. The degradation of the glycosaminoglycan heparan sulfate (HS) by the endo-β-D-glycosidase heparanase plays a critical role in multiple stages of the disease process.
Simeonovic, Charmaine, Popp, Sarah, Brown, Deborah, Li, Fei-Ju, Lafferty, Antony, Freeman, Craig, Parish, Christopher   +6 more
openaire   +3 more sources

Heparanase promotes neuroinflammatory response during subarachnoid hemorrhage in rats

Journal of Neuroinflammation, 2017
Background Heparanase, a mammalian endo-β-D-glucoronidase that specifically degrades heparan sulfate, has been implicated in inflammation and ischemic stroke.
Benjarat Changyaleket, Zhao Zhong Chong, Randal O. Dull, Danop Nanegrungsunk, Haoliang Xu   +4 more
doaj   +1 more source

Application of multiplexed ion mobility spectrometry towards the identification of host protein signatures of treatment effect in pulmonary tuberculosis. [PDF]

, 2018
RationaleThe monitoring of TB treatments in clinical practice and clinical trials relies on traditional sputum-based culture status indicators at specific time points.
Baker, Erin S, Burnum-Johnson, Kristin E, Gritsenko, Marina A, Jacobs, Jon M, Jarsberg, Leah G, Kedia, Komal, Lewinsohn, David M, Nahid, Payam, Piehowski, Paul D, Sigal, George B, Smith, Richard D, Stratton, Kelly G, Weiner, Marc H, Wendler, Jason P, Wright, Aaron T   +14 more
core  

Detection of Glycan Shedding in the Blood: New Class of Multiple Sclerosis Biomarkers? [PDF]

, 2018
Introduction: Multiple sclerosis (MS) is a devastating autoimmune disease, afflicting people in the prime of their lives. Presently, after initial clinical presentation, there are no reliable markers for whether a patient will develop MS, or whether ...
DellaValle, Brian, Hasseldam, Henrik, Hempel, Casper, Larsen, Agnete, Manresa-Arraut, Alba, Rungby, Jørgen, Stensballe, Allan   +6 more
core   +3 more sources

Perfusable Brain Microvascular Network‐On‐Chip Model to Study Flavivirus NS1‐Induced Endothelial Dysfunction

Advanced Functional Materials, Volume 35, Issue 50, December 9, 2025.
This study presents a microfluidic brain microvascular network‐on‐chip (BMVasChip) to investigate endothelial barrier dysfunction caused by flavivirus non‐structural protein 1 (NS1), including virus‐ and time‐dependent vascular damage, leakiness, and dysfunction.
Monika Rajput, Yen‐Ting Tung, Yu‐Chi Chen, Min Jae Song, Marc Ferrer, Emily M. Lee   +5 more
wiley   +1 more source