Results 91 to 100 of about 7,996 (174)

Association between blood glucose and heparanase levels.

, 2013
A, B. Urine and plasma heparanase levels presented according to gender. Shown are average (±SE) values of heparanase levels in urine (A) and plasma (B) quantified by ELISA in males (M) and females (F) of healthy volunteers (control), T2DM patients and ...
Itay Shafat (307738), Neta Ilan (48778), Israel Vlodavsky (48777), Samih Zoabi (355783), Farid Nakhoul (355784)   +4 more
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Heparanase affects food intake and regulates energy balance in mice.

PLoS ONE, 2012
Mutation of the melanocortin-receptor 4 (MC4R) is the most frequent cause of severe obesity in humans. Binding of agouti-related peptide (AgRP) to MC4R involves the co-receptor syndecan-3, a heparan sulfate proteoglycan.
Linda Karlsson-Lindahl, Linnéa Schmidt, David Haage, Caroline Hansson, Magdalena Taube, Emil Egecioglu, Ying-xia Tan, Therese Admyre, John-Olov Jansson, Israel Vlodavsky, Jin-Ping Li, Ulf Lindahl, Suzanne L Dickson   +12 more
doaj   +1 more source

The Heparanase Inhibitor PG545 Attenuates Colon Cancer Initiation and Growth, Associating with Increased p21 Expression

Neoplasia: An International Journal for Oncology Research, 2017
Heparanase activity is highly implicated in cellular invasion and tumor metastasis, a consequence of cleavage of heparan sulfate and remodeling of the extracellular matrix underlying epithelial and endothelial cells.
Preeti Singh, Alexandra Blatt, Sari Feld, Yaniv Zohar, Esraa Saadi, Liza Barki-Harrington, Edward Hammond, Neta Ilan, Israel Vlodavsky, Yehuda Chowers, Elizabeth Half   +10 more
doaj   +1 more source

Axonal trafficking of heparanase 1

, 2016
Heparanase 1 (HPA1) is the mammalian β-D-endoglycosidase that degrades heparan sulfate (HS). It is synthesized as a latent form (proheparanase) that lacks enzymatic activity.
Li, ZH, Lam, YL, Ma, CW, Shum, DKY, Chan, YS   +4 more
core  

Plasma heparanase is associated with blood glucose levels but not urinary microalbumin excretion in type 2 diabetic nephropathy at the early stage

Renal Failure, 2017
Aim: To explore the possible correlations between plasma heparanase and albuminuria, glucose and lipid metabolism in the type 2 diabetic nephropathy patients at the early stage.Methods: One hundred and forty patients with type 2 diabetic nephropathy at ...
Yue Zhao, Jingshun Liu, Shichao Ten, Jisheng Zhang, Yanggang Yuan, Jiangyi Yu, Xiaofei An   +6 more
doaj   +1 more source

Targeted disruption of the heparanase gene and generation of heparanase deficient mice.

, 2013
A. Structure of the 5′ end of the heparanase (Hpse) gene (top-normal allele), the targeting vector (middle- K/O allele), and the expected size of products obtained by digestion with Sca1 or EcoRv (bottom).
Xiao Zhang (152326), Lea Baraz (373410), Juan Jia (152320), Israel Vlodavsky (48777), Ulf Lindahl (175658), Jin-Ping Li (2265109), Eyal Zcharia (323457), Tamar Peretz (373411)   +7 more
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Heparanase promotes lymphangiogenesis and tumor invasion in pancreatic neuroendocrine tumors

, 2014
Heparan sulfate proteoglycans are an important and abundant component of the extracellular matrix, which undergo substantial remodeling throughout tumorigenesis via the enzymatic activity of heparanase. Heparanase has been shown to be upregulated in many
Palermo, C., Klimstra, D. S., Vlodavsky, I., Joyce, J. A., Simpson, K., Tang, L. H., Kester, J. C., Hunter, K. E., Li, Jin-ping,   +8 more
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Endothelial heparanase regulation of cardiac metabolism

, 2011
Following diabetes, the heart increases its lipoprotein lipase (LPL) at the coronary lumen by transferring LPL from the cardiomyocyte to the endothelial lumen.
Wang, Fang
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Role of heparanase on hepatic uptake of intestinal derived lipoprotein and fatty streak formation in mice.

PLoS ONE, 2011
BackgroundHeparanase modulates the level of heparan sulfate proteoglycans (HSPGs) which have an important role in multiple cellular processes. Recent studies indicate that HSPGs have an important function in hepatic lipoprotein handling and processes ...
David Planer, Shulamit Metzger, Eyal Zcharia, Isaiah D Wexler, Israel Vlodavsky, Tova Chajek-Shaul   +5 more
doaj   +1 more source

Heparanase Is Essential for the Development of Acute Experimental Glomerulonephritis

, 2016
Heparanase, a heparan sulfate (HS)-specific endoglucuronidase, mediates the onset of proteinuria and renal damage during experimental diabetic nephropathy. Glomerular heparanase expression is increased in most proteinuric diseases.
Jo H.M. Berden, Berden, Jo H. M.,, Dijkman, Henry B.,, Elkin, Michael,, Toin H. van Kuppevelt, Garsen, Marjolein,, Marilen Benner, Henry B. Dijkman, van der Vlag, Johan,, Rops, Angeligue L. W. M. M.,, Marjolein Garsen, Johan van der Vlag, Israel Vlodavsky, Angelique L.W.M.M. Rops, Li, Jin-Ping,, RabeLink, Ton J.,, Jin-Ping Li, Ton J. Rabelink, van Kuppevelt, Toin H.,, Michael Elkin, Benner, Marilen,, Vlodavsky, Israel,   +21 more
core   +1 more source