Results 81 to 90 of about 7,996 (174)

Assessment of Heparanase-Mediated Angiogenesis Using Microvascular Endothelial Cells: Identification of λ-Carrageenan Derivative as a Potent Anti Angiogenic Agent

Marine Drugs, 2017
Heparanase is overexpressed by tumor cells and degrades the extracellular matrix proteoglycans through cleavage of heparan sulfates (HS), allowing pro-angiogenic factor release and thus playing a key role in tumor angiogenesis and metastasis.
Nicolas Poupard, Pamela Badarou, Fabienne Fasani, Hugo Groult, Nicolas Bridiau, Frédéric Sannier, Stéphanie Bordenave-Juchereau, Claudine Kieda, Jean-Marie Piot, Catherine Grillon, Ingrid Fruitier-Arnaudin, Thierry Maugard   +11 more
doaj   +1 more source

Hepatocyte growth factor/c‐Met signaling axis in human diseases: Mechanistic insights and therapeutic potential

Journal of Cell Communication and Signaling, Volume 20, Issue 2, June 2026.
Figure 1 visually summarizes the core biological functions and therapeutic potential of the HGF/c‐Met signaling axis. Abstract Hepatocyte growth factor (HGF) is a multifunctional cytokine that activates the tyrosine kinase activity of its specific receptor, c‐Met (mesenchymal–epithelial transition factor).
Hongqin Sun, Hao Shu, Qian Zhang, Jishan Zheng, Yunyan Ma, Dengwang Chen, Jidong Zhang, Tao Song   +7 more
wiley   +1 more source

Heparanase in Acute Kidney Injury

, 2020
Recent years have brought about fledgling realization of the role played by heparanase in the pathogenesis of diverse diseases including kidney diseases and, specifically, acute kidney injury.
Zaid Abassi, Goligorsky, M. S., M. S. Goligorsky, Abassi, Zaid   +3 more
core   +1 more source

Heparanase Expression Correlates with Angiogenesis and Lymphangiogenesis in Human Lung Cancer

Chinese Journal of Lung Cancer, 2009
Background and objective Heparanase has been thought to be a good molecular marker of tumor, and the heparanase expression level was correlated closely with tumor metastasis.
Qingfu ZHANG, Jian MING, Yang LI, Siyang ZHANG, Bo LI, Xueshan QIU, Enhua WANG   +6 more
doaj  

Structural representation of antithrombin and heparanase.

, 2016
A) Molecular surface representation of antithrombin (1t1fA) and the structural model of human heparanase (3vny.1.A). Color blue represents positively charged surface and red displays anionic surface. White is assigned for neutral charged surface.
Irene Martínez-Martínez (355122), Nataliya Bohdan (2847428), Salvador Espín (2847431), Raúl Teruel-Montoya (2634832), Vicente Vicente (355123), Sonia Águila (2847425), Javier Corral (355116)   +6 more
core   +1 more source

Detection of Syndecan-1 and Heparanase-1 Genes in Esophageal Carcinoma by Quantitative RT-PCR

Cancer Biology & Medicine, 2010
OBJECTIVE To quantitatively explore the expression of Syndecan-1 and heparanase-1 in esophageal cancer tissue as well as their relationship with the clinicopathological factors, in order to evaluate their roles in tumor invasion and metastasis.METHODS
Jun-li SI, Yu-qin QI, Jing-yuan CUI
doaj   +1 more source

Purification and characterization of recombinant heparanase 2

, 2016
On mammalian cell surface, the role of extracellular matrix (ECM) is found to be crucial in providing structural support to cells. In addition, the ECM confers barrier property to nearby tissues and serves as a platform for growth factor binding and cell
Wong, Cheuk-ning, 黃卓寧
core   +1 more source

Upregulation of Endothelin-1/Endothelin A Receptor Expression Correlates with Heparanase Expression in Ovarian Carcinoma

Iranian Journal of Medical Sciences, 2018
Background: Heparanase and endothelin-1/endothelin A receptor (ET-1/ETAR) expressions increase in cancer. This condition enhances tumor progression and correlates with poor survival.
Nungki Anggorowati, Ahmad Ghozali, Irianiwati Widodo, Dwi Cahyani Ratna Sari, Muhammad Mansyur Romi, Nur Arfian   +5 more
doaj  

Endothelial Nitric Oxide Synthase Prevents Heparanase Induction and the Development of Proteinuria.

PLoS ONE, 2016
Endothelial nitric oxide synthase (eNOS) deficiency exacerbates proteinuria and renal injury in several glomerular diseases, but the underlying mechanism is not fully understood.
Marjolein Garsen, Angelique L Rops, Jinhua Li, Katrien van Beneden, Christiane van den Branden, Jo Hm Berden, Ton J Rabelink, Johan van der Vlag   +7 more
doaj   +1 more source

Abstracts

Molecular Oncology, Volume 20, Issue S1, Page 1-692, August 2026.
Abstracts submitted to the ‘EACR 2026 Congress: Innovative Cancer Science’, from 08–11 June 2026 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley   +1 more source