Results 101 to 110 of about 11,910 (223)

The Role of Heparanase in the Pathogenesis of Acute Pancreatitis: A Potential Therapeutic Target

Scientific Reports, 2017
Acute pancreatitis (AP) is one of the most common diseases in gastroenterology. However, neither the etiology nor the pathophysiology of the disease is fully understood and no specific or effective treatment has been developed.
Iyad Khamaysi, Preeti Singh, Susan Nasser, Hoda Awad, Yehuda Chowers, Edmond Sabo, Edward Hammond, Ian Gralnek, Irena Minkov, Alessandro Noseda, Neta Ilan, Israel Vlodavsky, Zaid Abassi   +12 more
doaj   +1 more source

The role of heparanase in pulmonary cell recruitment in response to an allergic but not non-allergic stimulus.

PLoS ONE, 2015
Heparanase is an endo-β-glucuronidase that specifically cleaves heparan sulfate proteoglycans in the extracellular matrix. Expression of this enzyme is increased in several pathological conditions including inflammation.
Abigail Morris, Bo Wang, Ida Waern, Radhakrishnan Venkatasamy, Clive Page, Eric P Schmidt, Sara Wernersson, Jin-Ping Li, Domenico Spina   +8 more
doaj   +1 more source

Heparanase and the hallmarks of cancer

Journal of Translational Medicine, 2020
Heparanase is the only mammalian enzyme that cleaves heparan sulphate, an important component of the extracellular matrix. This leads to the remodelling of the extracellular matrix, whilst liberating growth factors and cytokines bound to heparan sulphate.
Krishnath M. Jayatilleke, Mark D. Hulett
doaj   +1 more source

Unfolded protein response kinase PERK supports survival and metastasis of circulating tumor cell clusters via SAM synthesis and H3K4me3‐dependent PDGFB signaling

Cancer Communications, Volume 45, Issue 12, Page 1706-1733, December 2025.
Abstract Background Metastasis is the leading cause of cancer‐related mortality, with circulating tumor cell (CTC) clusters serving as highly efficient precursors of distant metastasis. Survival of CTC clusters in the bloodstream is the primary contributor to tumor metastasis.
Rui Tang, Yan Sun, Ao Deng, Jiahe Liu, Peijin Dai, Jing Chen, Chaoqun Deng, Hui Liu, Yuhang Hai, Yanran Tong, Yan‐e Du, Manran Liu, Haojun Luo   +12 more
wiley   +1 more source

Anti-Metastatic Properties of a Marine Bacterial Exopolysaccharide-Based Derivative Designed to Mimic Glycosaminoglycans [PDF]

, 2016
Osteosarcoma is the most frequent malignant primary bone tumor characterized by a high potency to form lung metastases. In this study, the effect of three oversulfated low molecular weight marine bacterial exopolysaccharides (OS-EPS) with different ...
Carmen Ruiz-Velasco, Colliec-Jouault, Corinne Sinquin, Dominique Heymann, Holen, Jacqueline Ratiskol, Julie Chesneau, Ma, Sylvia Colliec-Jouault, Vismara   +9 more
core   +3 more sources

Heparanase Expression Correlates with Angiogenesis and Lymphangiogenesis in Human Lung Cancer

Chinese Journal of Lung Cancer, 2009
Background and objective Heparanase has been thought to be a good molecular marker of tumor, and the heparanase expression level was correlated closely with tumor metastasis.
Qingfu ZHANG, Jian MING, Yang LI, Siyang ZHANG, Bo LI, Xueshan QIU, Enhua WANG   +6 more
doaj  

Newly generated heparanase knock-out mice unravel co-regulation of heparanase and matrix metalloproteinases.

PLoS ONE, 2009
BackgroundHeparanase, a mammalian endo-beta-D-glucuronidase, specifically degrades heparan sulfate proteoglycans ubiquitously associated with the cell surface and extracellular matrix.
Eyal Zcharia, Juan Jia, Xiao Zhang, Lea Baraz, Ulf Lindahl, Tamar Peretz, Israel Vlodavsky, Jin-Ping Li   +7 more
doaj   +1 more source

Proteoglycan neofunctions: regulation of inflammation and autophagy in cancer biology. [PDF]

, 2017
Inflammation and autophagy have emerged as prominent issues in the context of proteoglycan signaling. In particular, two small, leucine-rich proteoglycans, biglycan and decorin, play pivotal roles in the regulation of these vital cellular pathways and ...
Cohen IR, Douglass S, Kalas W, Mathiak M, Onita T, Zhu YH   +5 more
core   +2 more sources

Upregulation of Endothelin-1/Endothelin A Receptor Expression Correlates with Heparanase Expression in Ovarian Carcinoma

Iranian Journal of Medical Sciences, 2018
Background: Heparanase and endothelin-1/endothelin A receptor (ET-1/ETAR) expressions increase in cancer. This condition enhances tumor progression and correlates with poor survival.
Nungki Anggorowati, Ahmad Ghozali, Irianiwati Widodo, Dwi Cahyani Ratna Sari, Muhammad Mansyur Romi, Nur Arfian   +5 more
doaj  

Endothelial Nitric Oxide Synthase Prevents Heparanase Induction and the Development of Proteinuria.

PLoS ONE, 2016
Endothelial nitric oxide synthase (eNOS) deficiency exacerbates proteinuria and renal injury in several glomerular diseases, but the underlying mechanism is not fully understood.
Marjolein Garsen, Angelique L Rops, Jinhua Li, Katrien van Beneden, Christiane van den Branden, Jo Hm Berden, Ton J Rabelink, Johan van der Vlag   +7 more
doaj   +1 more source