Results 101 to 110 of about 7,996 (174)

Modulation of Endothelial Cell Migration by Heparanase [PDF]

Cancer cells need new angiogenesis to grow and invade into new areas. A currently accepted model of angiogenesis associated with cancers involves growth factors, such as fibroblast growth factor (FGF) and vascular endothelial growth factor (VEGF ...
HORIKAWA, Naoki
core   +2 more sources

Heparanase promotes glioma progression via enhancing CD24 expression

, 2019
Heparanase is an endo-beta-d-glucuronidase that cleaves heparan sulfate (HS) side chains of heparan sulfate proteoglycans. Compelling evidence tie heparanase levels with all steps of tumor formation including tumor initiation, growth, metastasis and ...
Juanjuan Luo, Neta Ilan, Spyrou, Argyris,, Liu, Pei,, Zhu, Chenchen,, Xiaojun Yang, Karin Forsberg‐Nilsson, Vlodaysky, Israel,, Dongsheng Su, Yang, Xiaojun,, Luo, Juanjuan,, Pei Liu, Barash, Uri,, Ilhan, Neta,, Israel Vlodavsky, Argyris Spyrou, Euvgeni Vlodavsky, Vlodaysky, Euvgeni,, Uri Barash, Su, Dongsheng,, Chenchen Zhu, Forsberg Nilsson, Karin,   +21 more
core   +1 more source

The Development of a Diagnostic Test for Heparanase Activity

, 2007
Heparan sulfate proteoglycans (HSPGs) are ubiquitous macromolecules located in the extracellular matrices and basement membranes; they present a physical barrier to the movement of cells (e.g., tumour cells and leukocytes) into tissues and play an ...
Pearson, Andrew
core   +1 more source

Eosinophil major basic protein: first identified natural heparanase-inhibiting protein

, 2004
BACKGROUND: Heparanase and eosinophils are involved in several diseases, including inflammation, cancer, and angiogenesis. OBJECTIVE: We sought to determine whether eosinophils produce active heparanase.
Zcharia E, PUXEDDU, ILARIA, Temkin V, Vlodavsky I, Goldshmidt O, Gleich GJ, Levi Schaffer F., Aingorn H   +7 more
core   +1 more source

Dysregulation of the Heparanase/TFPI-2/Heparan Sulfate Axis in Recurrent Pregnancy Loss. [PDF]

Int J Mol Sci
Yanovich C, Sabbah N, Asayag K, Crispel Y, Cohen H, Keren-Politansky A, Nadir Y.   +6 more
europepmc   +1 more source

Heparanase, Endothelial Dysfunction, and Cardiovascular Risk: The Emerging Role of Vitamin D. [PDF]

ACS Pharmacol Transl Sci
Chittoda A, Narwaria N, Varghese G, Kalita P, Ganta S, Kundu A.   +5 more
europepmc   +1 more source

Proteoglycans as Regulators of Receptor Trafficking and Spatial Signaling in Cancer. [PDF]

Cancers (Basel)
Berdiaki A, Konstantaraki M, Ajlan Z, Marmara M, Tsatsakis A, Tzanakakis G, Nikitovic D.   +6 more
europepmc   +1 more source

Non-anticoagulant heparins: glycan-mediated immune modulation and therapeutic applications. [PDF]

Front Immunol
Gu Y, Wang Q, Fang J, Chen J, Hong K, Zhang Z, Hassan SSU, Chen Y, Zhang X.   +8 more
europepmc   +1 more source

Heparanase inhibition prevents glycocalyx damage and albuminuria in experimental minimal change disease. [PDF]

Clin Transl Med
Crompton M, Ramnath RD, Betteridge K, Desideri S, Alonso AM, Jiang L, Gamez M, Stowell-Connolly H, Vasylchenko V, Onions KL, Butler MJ, Neal CR, Salmon AHJ, Turnbull JE, Kawachi H, Zubkova OV, Welsh GI, Satchell SC, Foster RR.   +18 more
europepmc   +1 more source

Heparanase cleavage of heparin modulates protease storage in mast cells

Overexpression of heparanase caused extensive degradation of heparan sulfate (HS), and elimination of heparanase resulted in non-degraded HS chains in mice.
Zcharia, Eyal,, Lindahl, Ulf,, Jia, Juan,, Zhang, Xiao,, Pejler, Gunnar,, Vlodavsky, Israel,, Li, Jin-ping,   +6 more
core   +2 more sources