Results 71 to 80 of about 7,996 (174)
Heparanase promotes neuroinflammatory response during subarachnoid hemorrhage in rats
Journal of Neuroinflammation, 2017 Background Heparanase, a mammalian endo-β-D-glucoronidase that specifically degrades heparan sulfate, has been implicated in inflammation and ischemic stroke.
Benjarat Changyaleket +4 more
doaj +1 more source
A compendium of extracellular vesicle biogenesis inhibitors: From bench to bedside
Interdisciplinary Medicine, Volume 4, Issue 4, July 2026.This review explores a decade of research on extracellular vesicles (EVs), detailing their biogenesis and roles in health and disease. It emphasizes EVs' relevance for potential medical applications covering various conditions such as cancer, neurodegeneration, inflammation, and infectious diseases, bridging experimental findings with clinical ...
Stefano Vecchione +2 more
wiley +1 more source
PLoS ONE, 2015 Heparanase is an endo-β-glucuronidase that specifically cleaves heparan sulfate proteoglycans in the extracellular matrix. Expression of this enzyme is increased in several pathological conditions including inflammation.
Abigail Morris +8 more
doaj +1 more source
Advances in Polyethyleneimine‐Derived Nanoformulations
Small Science, Volume 6, Issue 7, July 2026.This article illustrates the cytotoxic effects of polyethyleneimine (PEI) on cell membranes and mitochondria, the strategies employed to mitigate PEI‐associated toxicity through chemical modification, PEGylation, and structural optimization, and the major types of PEI‐based formulations developed for the delivery of therapeutic drugs, nucleic acids ...
Mohamed S. Attia +2 more
wiley +1 more source
Heparanase and Coagulation–New Insights
, 2014 Heparanase, a β-D-endoglucuronidase abundant in platelets that was discovered 30 years ago, is an enzyme that cleaves heparan sulfate side chains on the cell surface and in the extracellular matrix. It was later recognized as being a pro-inflammatory and
Yona Nadir
core +1 more source
Clinical Significance of Urine Heparanase in Bladder Cancer Progression
Neoplasia: An International Journal for Oncology Research, 2008 Heparanase is an endo-β-glucuronidase capable of cleaving heparan sulfate (HS), an activity implicated in tumor metastasis. Heparanase expression is upregulated in primary human tumors, correlating with reduced post operative survival and elevated ...
Itay Shafat +5 more
doaj +1 more source
The FEBS Journal, Volume 293, Issue 13, Page 3788-3813, July 2026.Irreversible ECM proteolysis by remodeling enzymes shapes development, homeostasis, and disease. ECM‐degrading proteases display cell specificity and are governed by shared mechanisms, exhibiting functional redundancy in generating matrikines, growth factors, and cytokines.
Inna Solomonov, Orit Kollet, Irit Sagi
wiley +1 more source
Possible mechanisms of apoEdp mediated heparanase inhibition.
, 2013 (A). Heparanase is produced as a larger precursor protein (pro-heparanase). LRP-1 on ECs known to rapidly bind the secreted pro-heparanase and transfer the internalized pro-heparanase to late endosomes/lysosomes. Pro-heparanase is proteolytically cleaved
Partha S. Bhattacharjee (75609) +11 more
core +1 more source
Heparanase processing by lysosomal/endosomal protein preparation [PDF]
, 2005 Heparanase is an endo-β-glucuronodase involved in cleavage of heparan sulfate side chains, activity that is strongly implicated in cell dissemination associated with tumor metastasis and inflammation.
Vlodavsky, Israel +7 more
core +1 more source
The Role of Heparanase in the Pathogenesis of Acute Pancreatitis: A Potential Therapeutic Target
Scientific Reports, 2017 Acute pancreatitis (AP) is one of the most common diseases in gastroenterology. However, neither the etiology nor the pathophysiology of the disease is fully understood and no specific or effective treatment has been developed.
Iyad Khamaysi +12 more
doaj +1 more source