Results 51 to 60 of about 11,910 (223)

Glycosaminoglycans and Glycosaminoglycan Mimetics in Cancer and Inflammation [PDF]

, 2019
Glycosaminoglycans (GAGs) are a class of biomolecules expressed virtually on all mammalian cells and usually covalently attached to proteins, forming proteoglycans.
Morla, Shravan
core   +1 more source

Alternative Pathway Dysregulation and the Conundrum of Complement Activation by IgG4 Immune Complexes in Membranous Nephropathy [PDF]

, 2016
Membranous nephropathy (MN), a major cause of nephrotic syndrome, is a non-inflammatory immune kidney disease mediated by IgG antibodies that form glomerular subepithelial immune complexes.
Dorin-Bogdan Borza
core   +2 more sources

Clinical Interpretation of Platelet Activation Marker sCLEC‐2 in Antiphospholipid Syndrome

Journal of Clinical Laboratory Analysis, EarlyView.
Soluble C‐type lectin‐like receptor 2 (sCLEC‐2), a marker of platelet activation, was evaluated in patients with antiphospholipid syndrome (APS). Plasma sCLEC‐2 levels and the sCLEC‐2/D‐dimer ratio were significantly elevated in APS compared with other collagen diseases and healthy controls.
Risa Kaneshige, Yukari Motoki, Kiyoshi Ichihara, Junzo Nojima   +3 more
wiley   +1 more source

Heparanase in primary human osteoblasts [PDF]

Journal of Orthopaedic Research, 2010
AbstractHeparanase (HPSE) is known to be involved in fracture repair in mice, but its presence and function in human bone formation remains unclear. Our aim was to determine the expression of HPSE in human bone forming osteoblasts and to better understand its role in osteogenesis.
Smith, Paul N., Freeman, Craig, Yu, Di, Chen, Mingming, Gatenby, Paul A., Parish, Christopher R., Li, Rachel W.   +6 more
openaire   +3 more sources

Extracellular matrix and proteolysis: mechanisms driving irreversible changes and shaping cell behavior

The FEBS Journal, EarlyView.
Irreversible ECM proteolysis by remodeling enzymes shapes development, homeostasis, and disease. ECM‐degrading proteases display cell specificity and are governed by shared mechanisms, exhibiting functional redundancy in generating matrikines, growth factors, and cytokines.
Inna Solomonov, Orit Kollet, Irit Sagi
wiley   +1 more source

Heparan sulfate mediates trastuzumab effect in breast cancer cells [PDF]

, 2013
Background: Trastuzumab is an antibody widely used in the treatment of breast cancer cases that test positive for the human epidermal growth factor receptor 2 (HER2).
Del Giglio, Auro, Nader, Helena Bonciani, Paredes-Gamero, Edgar Julian, Pinhal, Maria Aparecida Silva, Suarez, Eloah Rabello, Tersariol, Ivarne Luis dos Santos   +5 more
core   +2 more sources

Small RNA interference-mediated gene silencing of heparanase abolishes the invasion, metastasis and angiogenesis of gastric cancer cells

BMC Cancer, 2010
Background Heparanase facilitates the invasion and metastasis of cancer cells, and is over-expressed in many kinds of malignancies. Our studies indicated that heparanase was frequently expressed in advanced gastric cancers.
Hou Xiaohua, Dong Jihua, Pu Jiarui, Mei Hong, Jiang Guosong, Zheng Liduan, Tong Qiangsong   +6 more
doaj   +1 more source

Flow‐Induced Secretion of Endothelial Heparanase Regulates Cardiac Lipoprotein Lipase and Changes Following Diabetes

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022
Background Lipoprotein lipase (LPL)‐derived fatty acid is a major source of energy for cardiac contraction. Synthesized in cardiomyocytes, LPL requires translocation to the vascular lumen for hydrolysis of lipoprotein triglyceride, an action mediated by ...
Chae Syng Lee, Yajie Zhai, Rui Shang, Trevor Wong, Aurora J. Mattison, Haoning Howard Cen, James D. Johnson, Israel Vlodavsky, Bahira Hussein, Brian Rodrigues   +9 more
doaj   +1 more source

Heparan Sulfate Regrowth Profiles Under Laminar Shear Flow Following Enzymatic Degradation [PDF]

, 2012
The local hemodynamic shear stress waveforms present in an artery dictate the endothelial cell phenotype. The observed decrease of the apical glycocalyx layer on the endothelium in atheroprone regions of the circulation suggests that the glycocalyx may ...
A Koo, A Remuzzi, AB Baker, AG Khan, Andrew Jia-An Koo, AW Gross, AW Mulivor, AW Mulivor, BM Berg van den, C. Forbes Dewey, CK Payne, D Chappell, DR Potter, EC Kennett, EE Ebong, G Dai, G Rao, G. Villarreal, Guillermo Garcia-Cardena, HH Lipowsky, I Shafat, I Vlodavsky, I Vlodavsky, IV Fuki, JA Florian, Jagadish Sankaran, JD Esko, Jennifer H. Shin, Jiro Sakai, KM Ainslie, KM Parmar, Kristina M. Giantsos-Adams, L Gao, M Nikmanesh, M Yanagishita, M. Gouverneur, ML Ballinger, MY Pahakis, NM Carter, P Zimmermann, R. O. Dull, RH Adamson, S Sarrazin, S. Reitsma, Sukhyun Song, T Arisaka, TR Rudd, V Ferro, X Bai, Y Takeuchi, Y Yao   +50 more
core   +3 more sources

Tumor‐Resident Mast Cells Facilitated Breast Cancer Progression via Activating Type I Interferon Pathway

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Breast cancer cell‐derived stem cell factor (SCF) activates c‐KIT‐mediated MAPK/ERK signaling in mast cells, inducing IFNB1 production. Mast cell‐derived IFNB1 then engages the IFNAR1‐STAT1 axis in breast cancer cells, activating the Type I interferon pathway to promote tumor stemness and progression.
Siqin Li, Juchuanli Tu, Ruoyi Ding, Xueyan He, Xian Zhang, Mengxue Dong, Fengkai Li, Wen Yi, Yuwei Tao, Wei Ma, Zhijun Dai, Zhenhua Chen, Yuan Wang, Xiongbin Lu, Jian Liu, Suling Liu, Jiahui Xu   +16 more
wiley   +1 more source