Results 51 to 60 of about 7,996 (174)
BMC Cancer, 2010 Background Heparanase facilitates the invasion and metastasis of cancer cells, and is over-expressed in many kinds of malignancies. Our studies indicated that heparanase was frequently expressed in advanced gastric cancers.
Hou Xiaohua +6 more
doaj +1 more source
Maturation‐Dependent Constraints in the Ability of Human Monocytes to Initiate Trained Immunity
MedComm, Volume 7, Issue 10, October 2026.In premature infants, innate immune memory may serve as an important compensatory mechanism for the underdeveloped adaptive immune system. However, monocytes derived from prematurely born individuals display abnormal metabolic and insufficient transcriptomic responses to β‐glucan‐induced training.
Michael Eigenschink +10 more
wiley +1 more source
Personalized Zebrafish Models for Fusion‐Positive Pediatric Sarcomas
Pediatric Blood &Cancer, Volume 73, Issue 9, September 2026.ABSTRACT Clinical sequencing efforts have revolutionized our approaches to categorizing pediatric cancers in real time. This has dramatically improved our ability to profile pediatric tumors, identify actionable vulnerabilities, and influence clinical care.
Lisa H. Hall +2 more
wiley +1 more source
Role of heparanase and heparanase-degraded heparan sulfate in brain-metastatic melanoma [PDF]
, 2007 Cancer metastasis is a frequent manifestation of malignant melanoma progression. Successful invasion into distant organs by tumor cells must include attachment to microvessel endothelial cells, and degradation of extracellular matrix.
Roy, Madhuchhanda
core +1 more source
PLoS ONE, 2015 BackgroundUpregulation of heparanase has been reported in an increasing number of human cancer tissues. However, the level of salivary heparanase and its clinical significance in patients with salivary gland tumors remain unclear.MethodsSalivary ...
Xiangbing Wu +6 more
doaj +1 more source
Adaptive Genomic Divergence Across Altitudes in Capsella bursa‐pastoris
Biological Diversity, Volume 3, Issue 3, Page 125-135, September 2026.Genomic divergence was observed between high‐altitude and low‐altitude populations of Capsella bursa‐pastoris in China, consistent with an important role of ecological factors. Candidate adaptive loci associated with enhanced energy metabolism, photoprotection, and growth plasticity under altitudinal stress were identified.
Lu Liu +4 more
wiley +1 more source
PLoS ONE, 2008 Heparanase is a heparan sulfate (HS) degrading endoglycosidase participating in extracellular matrix degradation and remodeling. Apart of its well characterized enzymatic activity, heparanase was noted to exert also enzymatic-independent functions.
Flonia Levy-Adam +4 more
doaj +1 more source
Journal of Neuroscience Research, Volume 104, Issue 9, September 2026.Ubiquitous cell‐associated, cytoplasmic, synaptic and extracellular matrix HS‐proteoglycans are multifunctional regulators of tissue form and function. HS‐proteoglycans have diverse functions as growth factor co‐receptors in cell proliferation, differentiation, tissue development, mechanical stabilization, synaptogenesis, synaptic plasticity, and ...
James Melrose
wiley +1 more source
Heparanase Enhances Syndecan-1 Shedding
, 2007 When shed from the cell surface, the heparan sulfate proteoglycan syndecan-1 can facilitate the growth, angiogenesis, and metastasis of tumors. Here we report that tumor cell expression of heparanase, an enzyme known to be a potent promoter of tumor ...
Macleod, Veronica +21 more
core +1 more source
The expression and clinical significance of heparanase in non-small cell lung cancer
Chinese Journal of Lung Cancer, 2008 Background and objective It has been proven that heparanase played an important role in tumorigenesis. The aim of this work is to investigate the level of expression of heparanase protein in non-small cell lung cancer (NSCLC) and to explore the ...
Zuoqing SONG +4 more
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