Results 31 to 40 of about 11,910 (223)

Overexpression of long non-coding RNA NORAD promotes invasion and migration in malignant melanoma via regulating the MIR-205-EGLN2 pathway. [PDF]

, 2019
Growing evidence suggests that long non-coding RNAs NORAD and miR-205 play a significant role in regulating cancer progression and metastasis. In this study, high expression of NORAD was firstly observed in melanoma tissues and human malignant melanoma ...
Cao, Ke, Chen, Xiang, Chen, Yong, Li, Jingjing, Liu, Yan, Sun, Lichun, Tang, Jintian, Wang, Aijun, Xiong, Wei, Zhou, Jianda, Zhou, Xiao   +10 more
core   +1 more source

Inhibition of heparanase activity and heparanase‐induced angiogenesis by suramin analogues [PDF]

International Journal of Cancer, 2003
AbstractHeparanase, a heparan sulfate‐specific endo‐β‐D‐glucuronidase, plays an important role in tumor cell metastasis through the degradation of extracellular matrix heparan sulfate proteoglycans (ECM HSPG). Heparanase activity correlates with the metastatic propensity of tumor cells.
Dario, Marchetti, Jane, Reiland, Brad, Erwin, Madhuchhanda, Roy   +3 more
openaire   +2 more sources

Heparanase levels are elevated in the urine and plasma of type 2 diabetes patients and associate with blood glucose levels.

PLoS ONE, 2011
Heparanase is an endoglycosidase that specifically cleaves heparan sulfate side chains of heparan sulfate proteoglycans. Utilizing an ELISA method capable of detection and quantification of heparanase, we examined heparanase levels in the plasma and ...
Itay Shafat, Neta Ilan, Samih Zoabi, Israel Vlodavsky, Farid Nakhoul   +4 more
doaj   +1 more source

FGF23 is elevated in multiple myeloma and increases heparanase expression by tumor cells [PDF]

, 2015
Multiply myeloma (MM) grows in and destroys bone, where osteocytes secrete FGF23, a hormone which affects phosphate homeostasis and aging. We report that multiple myeloma (MM) cells express receptors for and respond to FGF23.
Chirgwin, John M., Crean, Colin D., Edwards, Daniel F., Fournier, Pierrick G., Ichikawa, Shoji, Imel, Erik A., Parker, Jamie M., Petyaykina, Katarina V., Sandusky, George E., Suvannasankha, Attaya, Tompkins, Douglas R.   +10 more
core   +2 more sources

Heparanase interacts with resistin and augments its activity.

PLoS ONE, 2014
In an attempt to isolate a heparanase receptor, postulated to mediate non-enzymatic functions of the heparanase protein, we utilized human urine collected from healthy volunteers.
Daniela Novick, Sara Barak, Neta Ilan, Israel Vlodavsky   +3 more
doaj   +1 more source

The proangiogenic capacity of polymorphonuclear neutrophils delineated by microarray technique and by measurement of neovascularization in wounded skin of CD18-deficient mice [PDF]

, 2006
Growing evidence supports the concept that polymorphonuclear neutrophils (PMN) are critically involved in inflammation-mediated angiogenesis which is important for wound healing and repair.
Addison CL, Armstrong DA, Baggiolini M, Barbara Walzog, Bazzoni F, Benelli R, Bernardini G, Bohnsack JF, Brandes ME, Cacalano G, Choudhuri R, Devalaraja RM, Dewald B, Dubravec DB, Gasperini S, Gaudry M, Grant DS, Grenier A, Grotendorst GR, Harada H, Heiple JM, Ikematsu S, Iruela-Arispe ML, John A, Jürgen Schymeinsky, Karin Scharffetter-Kochanek, Kreis C, Kullander K, Liu XH, Loukinova E, Matzner Y, Muramaki M, Niiro H, Oda N, Pertovaara L, Ramchandran R, Roberts AB, Ruth Schruefer, Sang QX, Sato W, Scapini P, Scharffetter-Kochanek K, Schruefer R, Sehgal I, Semenza GL, Shapiro SD, Silke Sulyok, Takada T, Takada T, Tasiemski A, Thorsten Peters, Triebel S, Walzog B, Wang SC, Willeke T, Yoshida S   +55 more
core   +1 more source

Heparanase Expression in Malignant Salivary Gl, Tumors Inversely Correlates with Long-Term Survival

Neoplasia: An International Journal for Oncology Research, 2006
BACKGROUND: Upregulation of the endo-b-Dglucuronidase, heparanase, was noted in an increasing number of human malignancies. Heparanase expression correlated with enhanced local, distant metastatic spread, increased vascular density, reduced postoperative
Ofer Ben-Izhak, Victoria Kaplan-Cohen, Neta Ilan, Shlomit Gan, Israel Vlodavsky, Rafael Nagler   +5 more
doaj   +1 more source

Nuclear Heparanase Regulates Chromatin Remodeling, Gene Expression and PTEN Tumor Suppressor Function

Cells, 2020
Heparanase (HPSE) is an endoglycosidase that cleaves heparan sulfate and has been shown in various cancers to promote metastasis, angiogenesis, osteolysis, and chemoresistance. Although heparanase is thought to act predominantly extracellularly or within
Rada Amin, Kaushlendra Tripathi, Ralph D. Sanderson   +2 more
doaj   +1 more source

Cellular internalization of alpha-synuclein aggregates by cell surface heparan sulfate depends on aggregate conformation and cell type. [PDF]

, 2017
Amyloid aggregates found in the brain of patients with neurodegenerative diseases, including Alzheimer's and Parkinson's disease, are thought to spread to increasingly larger areas of the brain through a prion-like seeding mechanism.
Esko, Jeffrey D, Ihse, Elisabet, Lawrence, Roger, Masliah, Eliezer, van Wijk, Xander M, Yamakado, Hodaka   +5 more
core   +2 more sources

Specific genes involved in synthesis and editing of heparan sulfate proteoglycans show altered expression patterns in breast cancer [PDF]

, 2013
This work was supported in part by the Instituto de Salud Carlos III-Fondo de Investigación Sanitaria (grant PI051564).
Astudillo González, María Aurora, Castañón, S., Crespo, A., Fernández Vega, Iván, García Suárez, Olivia, Menéndez Rodríguez, María Primitiva, Quirós Fernández, Luis Manuel   +6 more
core   +1 more source