Results 31 to 40 of about 7,996 (174)

Heparanase interacts with resistin and augments its activity.

PLoS ONE, 2014
In an attempt to isolate a heparanase receptor, postulated to mediate non-enzymatic functions of the heparanase protein, we utilized human urine collected from healthy volunteers.
Daniela Novick, Sara Barak, Neta Ilan, Israel Vlodavsky   +3 more
doaj   +1 more source

Heparanase levels are elevated in the urine and plasma of type 2 diabetes patients and associate with blood glucose levels.

PLoS ONE, 2011
Heparanase is an endoglycosidase that specifically cleaves heparan sulfate side chains of heparan sulfate proteoglycans. Utilizing an ELISA method capable of detection and quantification of heparanase, we examined heparanase levels in the plasma and ...
Itay Shafat, Neta Ilan, Samih Zoabi, Israel Vlodavsky, Farid Nakhoul   +4 more
doaj   +1 more source

Heparanase Expression in Malignant Salivary Gl, Tumors Inversely Correlates with Long-Term Survival

Neoplasia: An International Journal for Oncology Research, 2006
BACKGROUND: Upregulation of the endo-b-Dglucuronidase, heparanase, was noted in an increasing number of human malignancies. Heparanase expression correlated with enhanced local, distant metastatic spread, increased vascular density, reduced postoperative
Ofer Ben-Izhak, Victoria Kaplan-Cohen, Neta Ilan, Shlomit Gan, Israel Vlodavsky, Rafael Nagler   +5 more
doaj   +1 more source

Nuclear Heparanase Regulates Chromatin Remodeling, Gene Expression and PTEN Tumor Suppressor Function

Cells, 2020
Heparanase (HPSE) is an endoglycosidase that cleaves heparan sulfate and has been shown in various cancers to promote metastasis, angiogenesis, osteolysis, and chemoresistance. Although heparanase is thought to act predominantly extracellularly or within
Rada Amin, Kaushlendra Tripathi, Ralph D. Sanderson   +2 more
doaj   +1 more source

Targeting Heparanase in Cancer: Inhibition by Synthetic, Chemically Modified, and Natural Compounds

iScience, 2019
Heparanase is an endoglycosidase involved in remodeling the extracellular matrix and thereby in regulating multiple cellular processes and biological activities.
Chakrabhavi Dhananjaya Mohan, Swetha Hari, Habbanakuppe D. Preetham, Shobith Rangappa, Uri Barash, Neta Ilan, S. Chandra Nayak, Vijai K. Gupta, Basappa, Israel Vlodavsky, Kanchugarakoppal S. Rangappa   +10 more
doaj   +1 more source

Heparanase Modulates Chromatin Accessibility

, 2023
Heparanase is the sole endoglucuronidase that degrades heparan sulfate in the cell surface and extracellular matrix (ECM). Several studies have reported the localization of heparanase in the cell nucleus, but the functional role of the nuclear enzyme is ...
Xingqi Chen, Wang, Helen, Amelie Wenz, Wenz, Amelie S.,, Li, Honglian,, Hua Zhang, Wenz, Amelie S., Kang, Ziqi,, Li, Honglian, Zhang, Hua, Jinping Li, Chen, Xingqi, Vlodavsky, Israel, Zhang, Hua,, Honglian Li, Li, Jin-Ping, Wang, Helen,, Ziqi Kang, Israel Vlodavsky, Helen Wang, Li, Jin-Ping,, Kang, Ziqi, Vlodavsky, Israel,, Chen, Xingqi,   +23 more
core   +1 more source

DNA methylation of heparanase promoter influences its expression and associated with the progression of human breast cancer.

PLoS ONE, 2014
Heparanase promotes tumor invasion and metastasis in several malignancies including breast cancer. However, the roles and regulation mechanisms of heparanase during breast cancer progression are still not fully understood.
Fei Jiao, Shi-Yu Bai, Ying Ma, Zhong-Hai Yan, Zhen Yue, Yuan Yu, Xin Wang, Juan Wang   +7 more
doaj   +1 more source

Unfractionated Heparin and Low‐Molecular‐Weight Heparin in Sepsis: Anti‐Inflammatory and Anticoagulant Effects Versus No Anticoagulation—A Propensity Score‐Matched Analysis

Journal of Clinical Laboratory Analysis, EarlyView.
This propensity score‐matched study compared unfractionated heparin (UFH) and low‐molecular‐weight heparin (LMWH) in 1362 sepsis patients, finding that both significantly improved survival without increasing 90‐day bleeding risk. However, their therapeutic mechanisms differed: UFH demonstrated broader anti‐inflammatory effects by reducing IL‐6, IL‐8 ...
Peili Chen, Yi Yao, Bing Zhao, Yuan An, Jian Jiang, Li Ma, Enqiang Mao, Yihui Wang   +7 more
wiley   +1 more source

Synthesis of simple heparanase substrates

, 2011
Heparanase degrades heparan sulfate (HS) chains on proteoglycans; elevated levels of heparanase expression correlate with tumour cell metastatic potential and vascularity, and reduced post-operative survival of cancer patients.
Vito Ferro, Ferro, Vito, Milton J. Kiefel, Pearson, Andrew G, von Itzstein, Mark, Mark von Itzstein, Andrew G. Pearson, Pearson, Andrew G., Kiefel, Milton J., Kiefel, Milton, Kiefel, Milton J, Pearson, Andrew   +11 more
core   +1 more source

Soluble heparan sulfate fragments generated by heparanase trigger the release of pro-inflammatory cytokines through TLR-4.

PLoS ONE, 2014
Heparanase is a β-D-endoglucuronidase that cleaves heparan sulfate (HS), facilitating degradation of the extracellular matrix (ECM) and the release of HS-bound biomolecules including cytokines.
Katharine J Goodall, Ivan K H Poon, Simon Phipps, Mark D Hulett   +3 more
doaj   +1 more source