Leukocyte Heparanase: A Double-Edged Sword in Tumor Progression
Frontiers in Oncology, 2019 Heparanase is a β-D-endoglucuronidase that cleaves heparan sulfate, a complex glycosaminoglycan found ubiquitously throughout mammalian cells and tissues.
Alyce J. Mayfosh +3 more
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Heparanase and the hallmarks of cancer
Journal of Translational Medicine, 2020 Heparanase is the only mammalian enzyme that cleaves heparan sulphate, an important component of the extracellular matrix. This leads to the remodelling of the extracellular matrix, whilst liberating growth factors and cytokines bound to heparan sulphate.
Krishnath M. Jayatilleke, Mark D. Hulett
doaj +2 more sources
PLoS ONE, 2009 BackgroundHeparanase, a mammalian endo-beta-D-glucuronidase, specifically degrades heparan sulfate proteoglycans ubiquitously associated with the cell surface and extracellular matrix.
Eyal Zcharia +7 more
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Structural insights into pixatimod (PG545) inhibition of heparanase, a key enzyme in cancer and viral infections [PDF]
, 2022 Pixatimod (PG545), a heparan sulfate (HS) mimetic and anticancer agent currently in clinical trials, is a potent inhibitor of heparanase. Heparanase is an endo‐β‐glucuronidase that degrades HS in the extracellular matrix and basement membranes and is ...
Neha S. Gandhi +14 more
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Mechanisms and integrative machine learning approaches to blood-brain barrier biomarker profiling for personalized ischemic stroke management. [PDF]
Physiol RepAbstract Ischemic stroke remains a leading cause of death and disability worldwide, with blood–brain barrier (BBB) disruption playing a central role in vasogenic edema, neuroinflammation, hemorrhagic transformation, and secondary neuronal injury. The BBB is a specialized neurovascular unit composed of endothelial tight junctions, pericytes, astrocytes,
Nzobokela J +4 more
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Accumulation of Ym1 and formation of intracellular crystalline bodies in alveolar macrophages lacking heparanase [PDF]
, 2010 Heparanase is a heparan sulfate (HS) degrading endoglucuronidase that has been implicated in cell migration and inflammatory conditions. Here we used mice deficient of heparanase (Hpse−/−) to study the impact of heparanase on airway leukocytes.
Vlodavsky, Israel +12 more
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A Fluorogenic Heparan Sulfate Disaccharide for the Measurement of Heparanase Activity [PDF]
, 2020 The endo-β-glucuronidase heparanase mediates mammalian heparan sulfate catabolism, and is of considerable medical interest due to its prominent role in cancer aggression and metastasis.
Vito, Ferro +3 more
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Evidence for a genetic basis of urogenital carcinoma in the wild California sea lion [PDF]
, 2014 This work was funded by a grant from the US National Marine Fisheries Service John H. Prescott Marine Mammal Rescue Assistance grant programme, and H.M.B. was funded by a UK Natural Environment Research Council PhD studentship. J.A.H.
Dagleish, Mark P. +8 more
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Heparinase selectively sheds heparan sulphate from the endothelial glycocalyx [PDF]
, 2008 A healthy vascular endothelium is coated by the endothelial glycocalyx. Its main constituents are transmembrane syndecans and bound heparan sulphates. This structure maintains the physiological endothelial permeability barrier and prevents leukocyte and ...
Rehm, Markus +6 more
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Immunohistochemical expression of heparanase isoforms and syndecan-1 proteins in colorectal adenomas
European Journal of Histochemistry, 2016 The proteoglycan syndecan-1 and the endoglucuronidases heparanase-1 and heparanase-2 are involved in molecular pathways that deregulate cell adhesion during carcinogenesis.
J. Waisberg +6 more
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