Heparanase and autoimmune diabetes [PDF]
Frontiers in Immunology, 2015 Heparanase (Hpse) is the only known mammalian endo-β-d-glucuronidase that degrades the glycosaminoglycan heparan sulfate (HS), found attached to the core proteins of heparan sulfate proteoglycans (HSPGs).
Choong, Fui Jiun +5 more
core +5 more sources
Fully Synthetic Non-Carbohydrate Heparin Mimetics-Perspectives for Therapeutic Anticoagulation and Beyond? [PDF]
Arch Pharm (Weinheim)Fully synthetic sulfated non‐carbohydrate polymers for structurally mimicking the polysaccharide glycosaminoglycan heparin in its anticoagulant activities with further prospects to pleiotropic effects in oncology and in antiviral approaches. ABSTRACT Heparin is one of the oldest drugs on the market.
Nekipelov K, Ferro V, Bendas G.
europepmc +2 more sources
Development of Anti-Inflammatory Extracellular Vesicles by Surface Expression of Syndecan-4. [PDF]
J Extracell VesiclesABSTRACT The biological functions of extracellular vesicles (EVs) depend on their cellular source. Further, different subpopulations of EVs from the same cells carry different cargo, but differences in their biological functions are less understood. We here identify a very small EV subpopulation released by HEK293F cells (miniEVs).
Yu L +4 more
europepmc +2 more sources
Heparanase Modulates Chromatin Accessibility
Cells, 2023 Heparanase is the sole endoglucuronidase that degrades heparan sulfate in the cell surface and extracellular matrix (ECM). Several studies have reported the localization of heparanase in the cell nucleus, but the functional role of the nuclear enzyme is still obscure.
Honglian Li +7 more
openaire +4 more sources
Expression of heparanase in basal cell carcinoma and squamous cell carcinoma [PDF]
Anais Brasileiros de Dermatologia, 2016 : Background: Heparanase is an enzyme that cleaves heparan sulfate chains. Oligosaccharides generated by heparanase induce tumor progression. Basal cell carcinoma and squamous cell carcinoma comprise types of nonmelanoma skin cancer.
Maria Aparecida Silva Pinhal +5 more
doaj +1 more source
Heparanase-1: From Cancer Biology to a Future Antiviral Target
Viruses, 2023 Heparan sulfate proteoglycans (HSPGs) are a major constituent of the extracellular matrix (ECM) and are found to be implicated in viral infections, where they play a role in both cell entry and release for many viruses.
Nadjet Lebsir +2 more
doaj +1 more source
Current understanding of heparanase 2 regulation, a non-heparanase. [PDF]
Biochem Soc TransHeparan sulfate (HS) proteoglycans are life-supporting proteins comprising a core protein to which one or more HS glycan chains are covalently bound. HS proteoglycans act as binding sites for circulating cells and molecules, allow gradient formation, and provide local storage capacities.
Becker Y, Haller H.
europepmc +3 more sources
Non melanoma skin cancer pathogenesis overview [PDF]
, 2018 (1)Background: Non-melanoma skin cancer is the most frequently diagnosed cancer in humans. The process of skin carcinogenesis is still not fully understood.
Bottoni Ugo +3 more
core +1 more source
Heparanase overexpression reduces hepcidin expression, affects iron homeostasis and alters the response to inflammation [PDF]
, 2016 Hepcidin is the key regulator of systemic iron availability that acts by controlling the degradation of the iron exporter ferroportin. It is expressed mainly in the liver and regulated by iron, inflammation, erythropoiesis and hypoxia. The various agents
Arosio, Paolo +7 more
core +8 more sources
Immunohistochemical expression of heparanase isoforms and syndecan-1 proteins in colorectal adenomas
European Journal of Histochemistry, 2016 The proteoglycan syndecan-1 and the endoglucuronidases heparanase-1 and heparanase-2 are involved in molecular pathways that deregulate cell adhesion during carcinogenesis.
J. Waisberg +6 more
doaj +1 more source