Results 21 to 30 of about 11,910 (223)
Charge Characteristics of Agouti-Related Protein Implicate Potent Involvement of Heparan Sulfate Proteoglycans in Metabolic Function. [PDF]
, 2019 The endogenous melanocortin peptide agouti-related protein (AgRP) plays a well-known role in foraging, but its contribution to metabolic regulation is less understood.
Chen, Jihuan +9 more
core +1 more source
Heparanase: A Challenging Cancer Drug Target
Frontiers in Oncology, 2019 Heparanase has been viewed as a promising anti-cancer drug target for almost two decades, but no anti-heparanase therapy has yet reached the clinic.
Deirdre R. Coombe, Neha S. Gandhi
doaj +1 more source
Heparinase selectively sheds heparan sulphate from the endothelial glycocalyx [PDF]
, 2008 A healthy vascular endothelium is coated by the endothelial glycocalyx. Its main constituents are transmembrane syndecans and bound heparan sulphates. This structure maintains the physiological endothelial permeability barrier and prevents leukocyte and ...
Becker, Bernhard F. +6 more
core +1 more source
Heparanase inhibitors restrain mesothelioma [PDF]
Oncotarget, 2018 Malignant mesothelioma is a highly aggressive form of cancer with poor prognosis due to lack of markers for early diagnosis and resistance to conventional therapies. Heparanase, the sole heparan sulfate (HS) degrading endoglycosidase, regulates multiple biological activities that enhance tumor growth, metastasis, angiogenesis, and inflammation ...
Lapidot, Moshe +3 more
openaire +2 more sources
PLoS ONE, 2012 Heparanase is an endo-β-glucuronidase that cleaves heparan sulfate side chains, leading to structural modifications that loosen the extracellular matrix barrier and associated with tumor metastasis, inflammation and angiogenesis.
Itay Shafat +8 more
doaj +1 more source
Heparanase in cancer progression: Structure, substrate recognition and therapeutic potential
Frontiers in Chemistry, 2022 Heparanase, a member of the carbohydrate-active enzyme (CAZy) GH79 family, is an endo-β-glucuronidase capable of degrading the carbohydrate moiety of heparan sulphate proteoglycans, thus modulating and facilitating remodeling of the extracellular matrix.
Fengyan Yuan +7 more
doaj +1 more source
Focus on Molecules: Heparanase [PDF]
Experimental Eye Research, 2010 Heparanase (NP_001092010) is a heparin-binding endo-bD-glucuronidase expressed by normal lacrimal gland (GEO Profiles: GDS1361), corneal epithelia (Berk et al., 2004), retinal pigment epithelium/choroid, lens (NEIBank) and some non-ocular tissues. Heparanase is over-expressed in essentially all human tumors examined.
Yinghui, Zhang +5 more
openaire +2 more sources
Positive and negative regulation of angiogenesis by soluble vascular endothelial growth factor receptor-1 [PDF]
, 2018 Vascular endothelial growth factor receptor (VEGFR)-1 exists in different forms, derived from alternative splicing of the same gene. In addition to the transmembrane form, endothelial cells produce a soluble VEGFR-1 (sVEGFR-1) isoform, whereas non ...
Carbo, Miriam +2 more
core +2 more sources
Regulation of heparanase expression in coronary artery disease in diabetic, hyperlipidemic swine [PDF]
, 2010 Objective Enzymatic degradation of the extracellular matrix is known to be powerful regulator of atherosclerosis. However, little is known about the enzymatic regulation of heparan sulfate proteoglycans (HSPGs) during the formation and progression of ...
Baker, Aaron B. +12 more
core +1 more source
Neoplasia: An International Journal for Oncology Research, 2007 Heparanase is an endoglycosidase that specifically cleaves heparan sulfate (HS) side chains of heparan sulfate proteoglycans, the major proteoglycan in the extracellular matrix (ECM) and cell surfaces.
Itay Shafat +6 more
doaj +1 more source