Results 21 to 30 of about 7,996 (174)

Heparanase: A Challenging Cancer Drug Target

Frontiers in Oncology, 2019
Heparanase has been viewed as a promising anti-cancer drug target for almost two decades, but no anti-heparanase therapy has yet reached the clinic.
Deirdre R. Coombe, Neha S. Gandhi
doaj   +1 more source

Heparanase: Historical Aspects and Future Perspectives

, 2020
Heparanase is an endo-β-glucuronidase that cleaves at a limited number of internal sites the glycosaminoglycan heparan sulfate (HS). Heparanase enzymatic activity was first reported in 1975 and by 1983 evidence was beginning to emerge that the enzyme was
Mayank Khanna, Parish, Christopher, Christopher R. Parish, Khanna, Mayank   +3 more
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Heparanase – Discovery and Targets

, 2020
Heparanase was discovered during a study of the heparin proteoglycan (serglycin) in mast cells. Newly synthesized polysaccharide chains, kDa 60–100 x 103, were rapidly degraded to fragments similar in size to commercially available heparin (averaging 15 ...
Lindahl, Ulf,, Li, Jin-Ping,, Ulf Lindahl, Jin-Ping Li   +3 more
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Heparanase in cancer progression: Structure, substrate recognition and therapeutic potential

Frontiers in Chemistry, 2022
Heparanase, a member of the carbohydrate-active enzyme (CAZy) GH79 family, is an endo-β-glucuronidase capable of degrading the carbohydrate moiety of heparan sulphate proteoglycans, thus modulating and facilitating remodeling of the extracellular matrix.
Fengyan Yuan, Yiyuan Yang, Huiqin Zhou, Jing Quan, Chongyang Liu, Yi Wang, Yujing Zhang, Xing Yu   +7 more
doaj   +1 more source

Heparanase Levels Are Elevated in the Plasma of Pediatric Cancer Patients and Correlate with Response to Anticancer Treatment

Neoplasia: An International Journal for Oncology Research, 2007
Heparanase is an endoglycosidase that specifically cleaves heparan sulfate (HS) side chains of heparan sulfate proteoglycans, the major proteoglycan in the extracellular matrix (ECM) and cell surfaces.
Itay Shafat, Ayelet Ben Barak, Sergey Postovsky, Ronit Elhasid, Neta Ilan, Israel Vlodavsky, Miriam Weyl Ben Arush   +6 more
doaj   +1 more source

Heparanase in Kidney Disease

, 2020
Item does not contain fulltextThe primary filtration of blood occurs in the glomerulus in the kidney. Destruction of any of the layers of the glomerular filtration barrier might result in proteinuric disease.
Buijsers, B., Vlag, J. van der
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Structural Analysis of Heparanase Inhibition

, 2023
Heparanase (HPSE) is the only known mammalian endo-β-glucuronidase that catalyzes the degradation of heparan sulfate, a major component of the extracellular matrix in animals.
Whitefield, Cassidy
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Microvessel density and heparanase over-expression in clear cell renal cell cancer: correlations and prognostic significances

World Journal of Surgical Oncology, 2011
Background Tumor angiogenesis is important in the progression of malignancies, and heparanase plays an important role in sustaining the pathology of clear cell renal cell cancer (ccRCC).
Ren Juchao, Liu Hainan, Yan Lei, Tian Sujian, Li Dawei, Xu Zhonghua   +5 more
doaj   +1 more source

Involvement of Heparan Sulfate and Heparanase in Neural Development and Pathogenesis of Brain Tumors

, 2020
Brain tumors are aggressive and devastating diseases. The most common type of brain tumor, glioblastoma (GBM), is incurable and has one of the worst five-year survival rates of all human cancers.
Argyris Spyrou, Xiong, Anqi,, Spyrou, Argyris,, Anqi Xiong, Karin Forsberg-Nilsson, Forsberg Nilsson, Karin,   +5 more
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Heparanase e dislipidemia

, 2022
Trabalho Final do Curso de Mestrado Integrado em Medicina, Faculdade de Medicina, Universidade de Lisboa, 2022Introdução: A heparanase é uma enzima que degrada as cadeias de sulfato de heparano, cadeias que fazem parte dos proteoglicanos de sulfato de ...
Parodi, João Miguel Silva
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