Results 1 to 10 of about 11,910 (223)

Microvessel density and heparanase over-expression in clear cell renal cell cancer: correlations and prognostic significances [PDF]

World Journal of Surgical Oncology, 2011
Background Tumor angiogenesis is important in the progression of malignancies, and heparanase plays an important role in sustaining the pathology of clear cell renal cell cancer (ccRCC).
Ren Juchao, Liu Hainan, Yan Lei, Tian Sujian, Li Dawei, Xu Zhonghua   +5 more
doaj   +3 more sources

Increased Plasma Heparanase Activity in COVID-19 Patients

Frontiers in Immunology, 2020
Reports suggest a role of endothelial dysfunction and loss of endothelial barrier function in COVID-19. It is well established that the endothelial glycocalyx-degrading enzyme heparanase contributes to vascular leakage and inflammation.
Cansu Yanginlar, Inge Grondman, Marissa L Maciej-Hulme   +2 more
exaly   +3 more sources

Heparanase-Neutralizing Monoclonal Antibody (mAb A54) Attenuates Tumor Growth and Metastasis [PDF]

Cells
Heparanase is the only human enzyme responsible for heparan sulfate (HS) breakdown, an activity that remodels the extracellular matrix (ECM) and strongly drives cancer metastasis and angiogenesis.
Uri Barash, Malik Farhoud, Maali Odeh, Eliezer Huberman, Liang Wu, Israel Vlodavsky   +5 more
doaj   +2 more sources

Parabacteroides produces acetate to alleviate heparanase-exacerbated acute pancreatitis through reducing neutrophil infiltration

Microbiome, 2021
Background The endoglycosidase heparanase which degrades heparan sulfate proteoglycans, exerts a pro-inflammatory mediator in various inflammatory disorders. However, the function and underlying mechanism of heparanase in acute pancreatitis remain poorly
Yuanyuan Lei, Li Tang, Shuang Liu, Shiping Hu, Lingyi Wu, Yaojiang Liu, Min Yang, Shengjie Huang, Xuefeng Tang, Tao Tang, Xiaoyan Zhao, Israel Vlodavsky, Shuo Zeng, Bo Tang, Shiming Yang   +14 more
doaj   +1 more source

Impact of Heparanase and the Tumor Microenvironment on Cancer Metastasis and Angiogenesis: Basic Aspects and Clinical Applications

Rambam Maimonides Medical Journal, 2011
Heparanase is an endo-β-D-glucuronidase that cleaves heparan sulfate (HS) side chains at a limited number of sites, activity that is strongly implicated with cell invasion associated with cancer metastasis, a consequence of structural modification that ...
Israel Vlodavsky, Michael Elkin, Neta Ilan   +2 more
doaj   +1 more source

Increased Plasma Heparanase Activity and Endothelial Glycocalyx Degradation in Dengue Patients Is Associated With Plasma Leakage

Frontiers in Immunology, 2021
BackgroundEndothelial hyper-permeability with plasma leakage and thrombocytopenia are predominant features of severe dengue virus infection. It is well established that heparanase, the endothelial glycocalyx degrading enzyme, plays a major role in ...
Baranca Buijsers, Fadel Muhammad Garishah, Fadel Muhammad Garishah, Silvita Fitri Riswari, Silvita Fitri Riswari, Silvita Fitri Riswari, Rosalie M. van Ast, Setyo Gundi Pramudo, Setyo Gundi Pramudo, Rahajeng N. Tunjungputri, Rahajeng N. Tunjungputri, Gijs J. Overheul, Ronald P. van Rij, André van der Ven, Bachti Alisjahbana, Bachti Alisjahbana, Muhammad Hussein Gasem, Muhammad Hussein Gasem, Quirijn de Mast, Johan van der Vlag   +19 more
doaj   +1 more source

Heparanase and macrophage interplay in the onset of liver fibrosis [PDF]

, 2017
The heparan sulfate endoglycosidase heparanase (HPSE) is involved in tumor growth, chronic inflammation and fibrosis. Since a role for HPSE in chronic liver disease has not been demonstrated to date, the current study was aimed at investigating the ...
Crescenzi, Marika, Floreani, Annarosa, Masola, Valentina, Onisto, Maurizio, Russo, Francesco Paolo, Secchi, Maria Francesca   +5 more
core   +2 more sources

Heparanase enhances the generation of activated factor X in the presence of tissue factor and activated factor VII

Haematologica, 2010
Background Heparanase is an endo-β-D-glucuronidase dominantly involved in tumor metastasis and angiogenesis. Recently, we demonstrated that heparanase is involved in the regulation of the hemostatic system.
Yona Nadir, Benjamin Brenner, Liat Fux, Itay Shafat, Judith Attias, Israel Vlodavsky   +5 more
doaj   +1 more source

Involvement of heparanase in the pathogenesis of acute kidney injury: Nephroprotective effect of PG545 [PDF]

, 2017
Despite the high prevalence of acute kidney injury (AKI) and its association with increased morbidity and mortality, therapeutic approaches for AKI are disappointing. This is largely attributed to poor understanding of the pathogenesis of AKI. Heparanase,
Abassi, Zaid, Bellin, Gloria, Gambaro, Giovani, Hammond, Edward, Hamoud, Shadi, Hassan, Ahmad, Heyman, Samuel N., Ilan, Neta, Khamaysi, Iyad, Lupo, Antonio, Masola, Valentina, Muhammad, Rabia Shekh, Nativ, Omri, Onisto, Maurizio, Singh, Preeti, Vlodavsky, Israel, Zaza, Gianluigi   +16 more
core   +1 more source

Heparanase isoform expression and extracellular matrix remodeling in intervertebral disc degenerative disease

Clinics, 2011
OBJECTIVE: To determine the molecules involved in extracellular matrix remodeling and to identify and quantify heparanase isoforms present in herniated and degenerative discs.
Luciano Miller Reis Rodrigues, Thérèse Rachell Theodoro, Leandro Luongo Matos, Ana Maria Mader, Carlo Milani, Maria Aparecida da Silva Pinhal   +5 more
doaj   +1 more source