Results 1 to 10 of about 5,858 (119)

Heparanase-Neutralizing Monoclonal Antibody (mAb A54) Attenuates Tumor Growth and Metastasis [PDF]

Cells
Heparanase is the only human enzyme responsible for heparan sulfate (HS) breakdown, an activity that remodels the extracellular matrix (ECM) and strongly drives cancer metastasis and angiogenesis.
Uri Barash, Malik Farhoud, Maali Odeh, Eliezer Huberman, Liang Wu, Israel Vlodavsky   +5 more
doaj   +2 more sources

Parabacteroides produces acetate to alleviate heparanase-exacerbated acute pancreatitis through reducing neutrophil infiltration

Microbiome, 2021
Background The endoglycosidase heparanase which degrades heparan sulfate proteoglycans, exerts a pro-inflammatory mediator in various inflammatory disorders. However, the function and underlying mechanism of heparanase in acute pancreatitis remain poorly
Yuanyuan Lei, Li Tang, Shuang Liu, Shiping Hu, Lingyi Wu, Yaojiang Liu, Min Yang, Shengjie Huang, Xuefeng Tang, Tao Tang, Xiaoyan Zhao, Israel Vlodavsky, Shuo Zeng, Bo Tang, Shiming Yang   +14 more
doaj   +1 more source

Increased Plasma Heparanase Activity and Endothelial Glycocalyx Degradation in Dengue Patients Is Associated With Plasma Leakage

Frontiers in Immunology, 2021
BackgroundEndothelial hyper-permeability with plasma leakage and thrombocytopenia are predominant features of severe dengue virus infection. It is well established that heparanase, the endothelial glycocalyx degrading enzyme, plays a major role in ...
Baranca Buijsers, Fadel Muhammad Garishah, Fadel Muhammad Garishah, Silvita Fitri Riswari, Silvita Fitri Riswari, Silvita Fitri Riswari, Rosalie M. van Ast, Setyo Gundi Pramudo, Setyo Gundi Pramudo, Rahajeng N. Tunjungputri, Rahajeng N. Tunjungputri, Gijs J. Overheul, Ronald P. van Rij, André van der Ven, Bachti Alisjahbana, Bachti Alisjahbana, Muhammad Hussein Gasem, Muhammad Hussein Gasem, Quirijn de Mast, Johan van der Vlag   +19 more
doaj   +1 more source

Increased Plasma Heparanase Activity in COVID-19 Patients

Frontiers in Immunology, 2020
Reports suggest a role of endothelial dysfunction and loss of endothelial barrier function in COVID-19. It is well established that the endothelial glycocalyx-degrading enzyme heparanase contributes to vascular leakage and inflammation.
Baranca Buijsers, Cansu Yanginlar, Aline de Nooijer, Inge Grondman, Marissa L. Maciej-Hulme, Inge Jonkman, Nico A. F. Janssen, Nils Rother, Mark de Graaf, Peter Pickkers, Peter Pickkers, Matthijs Kox, Matthijs Kox, Leo A. B. Joosten, Tom Nijenhuis, Mihai G. Netea, Mihai G. Netea, Luuk Hilbrands, Frank L. van de Veerdonk, Raphaël Duivenvoorden, Raphaël Duivenvoorden, Quirijn de Mast, Johan van der Vlag   +22 more
doaj   +1 more source

Impact of Heparanase and the Tumor Microenvironment on Cancer Metastasis and Angiogenesis: Basic Aspects and Clinical Applications

Rambam Maimonides Medical Journal, 2011
Heparanase is an endo-β-D-glucuronidase that cleaves heparan sulfate (HS) side chains at a limited number of sites, activity that is strongly implicated with cell invasion associated with cancer metastasis, a consequence of structural modification that ...
Israel Vlodavsky, Michael Elkin, Neta Ilan   +2 more
doaj   +1 more source

Heparanase enhances the generation of activated factor X in the presence of tissue factor and activated factor VII

Haematologica, 2010
Background Heparanase is an endo-β-D-glucuronidase dominantly involved in tumor metastasis and angiogenesis. Recently, we demonstrated that heparanase is involved in the regulation of the hemostatic system.
Yona Nadir, Benjamin Brenner, Liat Fux, Itay Shafat, Judith Attias, Israel Vlodavsky   +5 more
doaj   +1 more source

Heparanase isoform expression and extracellular matrix remodeling in intervertebral disc degenerative disease

Clinics, 2011
OBJECTIVE: To determine the molecules involved in extracellular matrix remodeling and to identify and quantify heparanase isoforms present in herniated and degenerative discs.
Luciano Miller Reis Rodrigues, Thérèse Rachell Theodoro, Leandro Luongo Matos, Ana Maria Mader, Carlo Milani, Maria Aparecida da Silva Pinhal   +5 more
doaj   +1 more source

Elevated urine heparanase levels are associated with proteinuria and decreased renal allograft function.

PLoS ONE, 2012
Heparanase is an endo-β-glucuronidase that cleaves heparan sulfate side chains, leading to structural modifications that loosen the extracellular matrix barrier and associated with tumor metastasis, inflammation and angiogenesis.
Itay Shafat, Amir Agbaria, Mona Boaz, Doron Schwartz, Ronny Baruch, Richard Nakash, Neta Ilan, Israel Vlodavsky, Talia Weinstein   +8 more
doaj   +1 more source

Expression of heparanase in basal cell carcinoma and squamous cell carcinoma [PDF]

Anais Brasileiros de Dermatologia, 2016
: Background: Heparanase is an enzyme that cleaves heparan sulfate chains. Oligosaccharides generated by heparanase induce tumor progression. Basal cell carcinoma and squamous cell carcinoma comprise types of nonmelanoma skin cancer.
Maria Aparecida Silva Pinhal, Maria Carolina Leal Almeida, Alessandra Scorse Costa, Thérèse Rachell Theodoro, Rodrigo Lorenzetti Serrano, Carlos D'Apparecida Santos Machado Filho   +5 more
doaj   +1 more source

Heparanase-1: From Cancer Biology to a Future Antiviral Target

Viruses, 2023
Heparan sulfate proteoglycans (HSPGs) are a major constituent of the extracellular matrix (ECM) and are found to be implicated in viral infections, where they play a role in both cell entry and release for many viruses.
Nadjet Lebsir, Fabien Zoulim, Boyan Grigorov   +2 more
doaj   +1 more source