Results 41 to 50 of about 11,910 (223)

DNA methylation of heparanase promoter influences its expression and associated with the progression of human breast cancer.

PLoS ONE, 2014
Heparanase promotes tumor invasion and metastasis in several malignancies including breast cancer. However, the roles and regulation mechanisms of heparanase during breast cancer progression are still not fully understood.
Fei Jiao, Shi-Yu Bai, Ying Ma, Zhong-Hai Yan, Zhen Yue, Yuan Yu, Xin Wang, Juan Wang   +7 more
doaj   +1 more source

Soluble heparan sulfate fragments generated by heparanase trigger the release of pro-inflammatory cytokines through TLR-4.

PLoS ONE, 2014
Heparanase is a β-D-endoglucuronidase that cleaves heparan sulfate (HS), facilitating degradation of the extracellular matrix (ECM) and the release of HS-bound biomolecules including cytokines.
Katharine J Goodall, Ivan K H Poon, Simon Phipps, Mark D Hulett   +3 more
doaj   +1 more source

Syndecan-1-Dependent Regulation of Heparanase Affects Invasiveness, Stem Cell Properties, and Therapeutic Resistance of Caco2 Colon Cancer Cells

Frontiers in Oncology, 2020
The heparan sulfate proteoglycan Syndecan-1 binds cytokines, morphogens and extracellular matrix components, regulating cancer stem cell properties and invasiveness.
Sampath Kumar Katakam, Paride Pelucchi, Cinzia Cocola, Rolland Reinbold, Israel Vlodavsky, Burkhard Greve, Martin Götte   +6 more
doaj   +1 more source

Isomalto oligosaccharide sulfate inhibits tumor growth and metastasis of hepatocellular carcinoma in nude mice [PDF]

, 2011
Background Hepatocellular carcinoma (HCC) usually has a dismal prognosis because of its limited response to current pharmacotherapy and high metastatic rate.
Chun-Li Xiao, Zhong-Hua Tao, Lin Guo, Wei-Wei Li, Jin-Liang Wan, Hui-Chuan Sun, Lu Wang, Zhao-You Tang, Jia Fan, Wei-Zhong Wu   +9 more
core   +1 more source

Adaptive Genomic Divergence Across Altitudes in Capsella bursa‐pastoris

Biological Diversity, EarlyView.
Genomic divergence was observed between high‐altitude and low‐altitude populations of Capsella bursa‐pastoris in China, consistent with an important role of ecological factors. Candidate adaptive loci associated with enhanced energy metabolism, photoprotection, and growth plasticity under altitudinal stress were identified.
Lu Liu, Jia Li, Xin Liu, Xue‐Jun Ge, Hui‐Run Huang   +4 more
wiley   +1 more source

Analysis of heparanase isoforms and cathepsin B in the plasma of patients with gastrointestinal carcinomas: analytical cross-sectional study

São Paulo Medical Journal
CONTEXT AND OBJECTIVE: Heparanase-1 degrades heparan sulfate and has been correlated with tumor progression.
Carina Mucciolo Melo, Clarice Silvia Taemi Origassa, Thérèse Rachell Theodoro, Leandro Luongo Matos, Thaís Aguilar Miranda, Camila Melo Accardo, Rodrigo Ippolito Bouças, Eloah Rabello Suarez, Madalena Maria Nunes Silva Pares, Daniel Reis Waisberg, Giovanna Canato Toloi, Helena Bonciani Nader, Jaques Waisberg, Maria Aparecida Silva Pinhal   +13 more
doaj   +1 more source

Activity-based probes for functional interrogation of retaining β-glucuronidases [PDF]

, 2017
Humans express at least two distinct β-glucuronidase enzymes that are involved in disease: exo-acting β-glucuronidase (GUSB), whose deficiency gives rise to mucopolysaccharidosis type VII, and endo-acting heparanase (HPSE), whose overexpression is ...
Aerts, Johannes M.F.G., Artola, Marta, Codée, Jeroen D.C., Dai, Wei, Davies, Gideon J., Florea, Bogdan I., Jiang, Jianbing, Jin, Yi, Kallemeijn, Wouter W., Kuo, Chi Lin, Overkleeft, Herman S., Van Der Marel, Gijsbert A., Van Eijk, Marco, Van Elk, Cas, Wu, Liang   +14 more
core   +2 more sources

Engineering exosomal cargo loading via endogenous molecular pathways: Strategies to enhance therapeutic potential

Interdisciplinary Medicine, EarlyView.
This review illustrates how scientists engineer exosomes by hijacking the cell's own cargo‐sorting machinery. These strategies efficiently load therapeutic molecules into natural vesicles, creating powerful next‐generation drug delivery systems (Created with BioGDP.com).
Huanrong Zhu, Chenning Zhang, Shihan Ma, Zhanxue Xu, Cailing Liang, Fang Cheng, Hongbo Chen   +6 more
wiley   +1 more source

Targeting Heparanase in Cancer: Inhibition by Synthetic, Chemically Modified, and Natural Compounds

iScience, 2019
Heparanase is an endoglycosidase involved in remodeling the extracellular matrix and thereby in regulating multiple cellular processes and biological activities.
Chakrabhavi Dhananjaya Mohan, Swetha Hari, Habbanakuppe D. Preetham, Shobith Rangappa, Uri Barash, Neta Ilan, S. Chandra Nayak, Vijai K. Gupta, Basappa, Israel Vlodavsky, Kanchugarakoppal S. Rangappa   +10 more
doaj   +1 more source

Radiation-Induced Nephropathy in the Murine Model Is Ameliorated by Targeting Heparanase

Biomedicines, 2023
Agents used to reduce adverse effects common in cancer treatment modalities do not typically possess tumor-suppressing properties. We report that heparanase, an extracellular matrix-degrading enzyme, is a promising candidate for preventing radiation ...
Alexia Abecassis, Esther Hermano, Kim Sheva, Ariel M. Rubinstein, Michael Elkin, Amichay Meirovitz   +5 more
doaj   +1 more source