Results 61 to 70 of about 7,996 (174)
Neuroprotection, Volume 4, Issue 3, Page 213-228, September 2026.ECM, extracellular matrix; BDNF, brain‐derived neuroptrophic factor; FGF, fibroblast growth factor; VEGF, vascular endothelial growth factor. Abstract Heparan sulfate, a structurally diverse glycosaminoglycan that is abundant in the central nervous system (CNS), orchestrates essential processes fundamental to neural plasticity, neurorepair, and ...
Mozammel H. Bhuiyan +3 more
wiley +1 more source
, 2013 A. Prolonged survival of mice treated with heparanase. Mice were sublethally irradiated (750 cGy) and transplanted i.v with 10×106 spleen cells from heparanase treated or un-treated C57BL/6 mice (5 µg/mouse/day, i.p. for 3 days).
Lola Weiss (365487) +6 more
core +1 more source
Increased chemotactic migration and growth in heparanase-overexpressing human U251n glioma cells
Journal of Experimental & Clinical Cancer Research, 2008 Heparanase is an endoglycosidase that degrades heparan sulfate, the main polysaccharide constituent of the extracellular matrix (ECM) and basement membrane.
Zheng Xuguang +8 more
doaj +1 more source
Cancer Medicine, Volume 15, Issue 8, August 2026.ABSTRACT Extramedullary disease (EMD) in newly diagnosed multiple myeloma (NDMM) is aggressive and associated with worse survival. This study aimed to comprehensively evaluate the clinical outcomes and factors affecting prognosis in NDMM patients with EMD receiving novel agents‐based induction therapy.
Xiaoxi Xu +7 more
wiley +1 more source
The multi-factorial aetiology of urogenital carcinoma in the California sea lion (Zalophus californianus) : a case-control study [PDF]
, 2014 California sea lions (CSLs) have an unusually high occurrence of urogenital cancer (UGC), with studies revealing metastatic carcinoma in 26 % of CSLs admitted to a rehabilitation centre between 1998 and 2012.
Browning, Helen M.
core +1 more source
Neoplasia: An International Journal for Oncology Research, 2006 Heparanase is an endoglycosidase that specifically cleaves heparan sulfate (HS) side chains of HS proteoglycans, the major proteoglycans in the extracellular matrix and cell surfaces. Traditionally, heparanase activity was implicated in cellular invasion
Ilana Doweck +5 more
doaj +1 more source
Heparanase: a potential marker of worse prognosis in estrogen receptor-positive breast cancer
npj Breast Cancer, 2021 Heparanase promotes tumor growth in breast tumors. We now evaluated heparanase protein and gene-expression status and investigated its impact on disease-free survival in order to gain better insight into the role of heparanase in ER-positive (ER+) breast
Tamar Zahavi +14 more
doaj +1 more source
Autophagy Modulation in Cancer Therapy: Navigating the Dual Roles to Overcome Chemoresistance
Health Science Reports, Volume 9, Issue 8, August 2026.ABSTRACT Background Autophagy is a fundamental cellular recycling mechanism with complex and often opposing roles in cancer, functioning as both a tumor suppressor and a pro‐survival mechanism in established tumors. This duality has attracted considerable attention, particularly regarding the therapeutic modulation of autophagy to overcome ...
Md Mohiuddin, Md Al Mamun Ahsan
wiley +1 more source
Cell Proliferation, Volume 59, Issue 8, August 2026.Elucidating the contribution of gut‐organ axes will provide new insights for developing combined therapeutic strategies against sepsis‐associated multiple organ dysfunction. ABSTRACT Sepsis, a life‐threatening clinical syndrome precipitated by a maladaptive host response to infection, is associated with substantial morbidity and high mortality rates ...
Yichen Bao +7 more
wiley +1 more source
Co-immunoprecipitation of heparanase with resistin.
, 2014 A: Lanes 1–6: co-immunprecipitation of resistin with either latent cMyc-heparanase or active heparanase imunoprecipitated with the indicated antibodies. Lane 7: a reference resisitin without co-immunprecipitation was run on the same gel.
Neta Ilan (48778) +3 more
core +1 more source