Results 61 to 70 of about 11,910 (223)
PLoS ONE, 2015 Heparanase is an endo-β-glucuronidase that cleaves heparan sulfate side chains from their proteoglycans. Thereby, heparanase liberates highly potent circulating heparan sulfate-fragments (HS-fragments) and triggers the fatal and excessive inflammatory ...
Lukas Martin +8 more
doaj +1 more source
Animal Models of Hunner‐Type Interstitial Cystitis
International Journal of Urology, Volume 33, Issue 5, May 2026.ABSTRACT Background Animal models are crucial for mechanistic studies and therapeutic development of human diseases. At present, the etiology of interstitial cystitis/bladder pain syndrome (IC/BPS), a chronic disease of the urinary bladder, remains undefined.
Yoshiyuki Akiyama, Yi Luo
wiley +1 more source
PLoS ONE, 2008 Heparanase is a heparan sulfate (HS) degrading endoglycosidase participating in extracellular matrix degradation and remodeling. Apart of its well characterized enzymatic activity, heparanase was noted to exert also enzymatic-independent functions.
Flonia Levy-Adam +4 more
doaj +1 more source
Hepatic heparan sulfate is a master regulator of hepcidin expression and iron homeostasis in human hepatocytes and mice. [PDF]
, 2019 Hepcidin is a liver-derived peptide hormone that controls systemic iron homeostasis. Its expression is regulated by the bone morphogenetic protein 6 (BMP6)/SMAD1/5/8 pathway and by the proinflammatory cytokine interleukin 6 (IL6).
Anower-E-Khuda, Ferdous +8 more
core
Basement membrane proteoglycans: modulators Par Excellence of cancer growth and angiogenesis. [PDF]
, 2009 Proteoglycans located in basement membranes, the nanostructures underling epithelial and endothelial layers, are unique in several respects. They are usually large, elongated molecules with a collage of domains that share structural and functional ...
Iozzo, Renato V +2 more
core +2 more sources
PLoS ONE, 2015 BackgroundUpregulation of heparanase has been reported in an increasing number of human cancer tissues. However, the level of salivary heparanase and its clinical significance in patients with salivary gland tumors remain unclear.MethodsSalivary ...
Xiangbing Wu +6 more
doaj +1 more source
Association of Porcine Heparanase and Hyaluronidase 1 and 2 with Reproductive and Production Traits in a Landrace–Duroc–Yorkshire Population [PDF]
, 2011 The ovary and placenta are dynamic structures requiring constant modification both structurally and through cell-cell communication capabilities. The extracellular matrix and basement membranes are primarily composed of a milieu of glycosaminoglycans ...
Lea A. Rempel +6 more
core +1 more source
Serum heparanase concentration and heparanase activity in patients with retinal vein occlusion [PDF]
Acta Ophthalmologica, 2016 AbstractPurposeTo investigate the serum heparanase concentration and heparanase activity of the patients with central retinal vein occlusion (CRVO) or branch retinal vein occlusion (BRVO).MethodsThis prospective study included 23 CRVO patients, 13 BRVO patients and 28 control subjects. Serum heparanase concentration was measured by ELISA.
Yijun, Hu +10 more
openaire +2 more sources
The expression and clinical significance of heparanase in non-small cell lung cancer
Chinese Journal of Lung Cancer, 2008 Background and objective It has been proven that heparanase played an important role in tumorigenesis. The aim of this work is to investigate the level of expression of heparanase protein in non-small cell lung cancer (NSCLC) and to explore the ...
Zuoqing SONG +4 more
doaj
MedComm, Volume 7, Issue 4, April 2026.Targeted protein degradation represents a paradigm shift from traditional protein inhibition to complete protein elimination. This is achieved through three main strategies for degrading extracellular and membrane proteins: recruitment of cell‐surface LTRs, engagement of intracellular proteins, and receptor‐independent mechanisms.
Mengqing Zhao +6 more
wiley +1 more source