Results 181 to 190 of about 11,910 (223)
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2020
The primary filtration of blood occurs in the glomerulus in the kidney. Destruction of any of the layers of the glomerular filtration barrier might result in proteinuric disease. The glomerular endothelial cells and especially its covering layer, the glycocalyx, play a pivotal role in development of albuminuria.
Vlag, J. van der, Buijsers, B.
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The primary filtration of blood occurs in the glomerulus in the kidney. Destruction of any of the layers of the glomerular filtration barrier might result in proteinuric disease. The glomerular endothelial cells and especially its covering layer, the glycocalyx, play a pivotal role in development of albuminuria.
Vlag, J. van der, Buijsers, B.
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Heparanase in Acute Pancreatitis
2020Acute pancreatitis (AP) is one of the most common diseases in gastroenterology, affecting 2% of all hospitalized patients. Nevertheless, neither the etiology nor the pathophysiology of the disease is fully characterized, and no specific or effective treatment has been developed.
Iyad, Khamaysi +2 more
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Heparanases and tumor metastasis
Journal of Cellular Biochemistry, 1988AbstractThe successful penetration of endothelial basement membranes is an important process in the formation of hematogenous tumor metastases. Heparan sulfate (HS) proteoglycan is a major constituent of endothelial basement membranes, and we have found that HS‐degradative activities of metastatic B16 melanoma sublines correlate with their lung ...
M, Nakajima, T, Irimura, G L, Nicolson
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Heparanase – Discovery and Targets
2020Heparanase was discovered during a study of the heparin proteoglycan (serglycin) in mast cells. Newly synthesized polysaccharide chains, kDa 60-100 x 103, were rapidly degraded to fragments similar in size to commercially available heparin (averaging 15 x 103).
Ulf, Lindahl, Jin-Ping, Li
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New Advances of Heparanase and Heparanase-2 in Human Diseases
Archives of Medical Research, 2018As we all know, heparanase plays an important role in human diseases. As a kind of endo-β-glucuronidase, heparanase is the known only enzyme in mammals which could degrade heparan sulfate(HS) specifically. HS is a vital component of extracellular matrix(ECM).
Hao, Jin, Min, Cui
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The Good and Bad Sides of Heparanase-1 and Heparanase-2
2020In this chapter, we will emphasize the importance of heparan sulfate proteoglycans (HSPG) in controlling various physiological and pathological molecular mechanisms and discuss how the heparanase enzyme can modulate the effects triggered by HSPG. Additionally, we will also navigate about the existing knowledge of the possible role of heparanase-2 in ...
Maria Aparecida Silva, Pinhal +2 more
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Opposing Effects of Heparanase and Heparanase-2 in Head & Neck Cancer
2020Squamous cell carcinoma of head and neck (SCCHN) is the most common cancer in the head and neck and is the sixth most common neoplasm worldwide. SCCHN has a high propensity to lymph node metastases, especially cancer of the pharynx. Prognosis of patients with SCCHN is severely influenced by the status of metastatic cervical lymph nodes and survival ...
Ilana, Doweck, Nir, Feibish
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Heparanase, Tissue Factor, and Cancer
Seminars in Thrombosis and Hemostasis, 2008Heparanase is an endo-beta- D-glucuronidase that is capable of cleaving heparan sulfate side chains of heparan sulfate proteoglycans on cell surfaces and the extracellular matrix, activity that is strongly implicated in tumor metastasis and angiogenesis.
Yona, Nadir +2 more
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Heparanase: Cloning, Function and Regulation
2020In 2019, we mark the 20th anniversary of the cloning of the human heparanase gene. Heparanase remains the only known enzyme to cleave heparan sulfate, which is an abundant component of the extracellular matrix. Thus, elucidating the mechanisms underlying heparanase expression and activity is critical to understanding its role in healthy and ...
Shaun M, Gaskin +2 more
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Heparanase multiple effects in cancer
Thrombosis Research, 2014Heparanase is an endo-β-D-glucuronidase that is capable of cleaving heparan sulfate side chains of heparan sulfate proteoglycans on cell surfaces and the extracellular matrix, activity that is strongly implicated in tumor metastasis and angiogenesis.
Yona, Nadir, Benjamin, Brenner
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