Results 1 to 10 of about 565,675 (350)

Effect of fibronectin on the binding of antithrombin III to immobilized heparin [PDF]

, 1996
An objective of this research is to verify the mechanism of anticoagulant activity of surface-immobilized heparin in the presence of plasma proteins.
Byun, Youngro, Feijen, Jan, Jacobs, Harvey A., Kim, Sung Wan   +3 more
core   +37 more sources

Platelet factor 4 polyanion immune complexes: heparin induced thrombocytopenia and vaccine-induced immune thrombotic thrombocytopenia

Thrombosis Journal, 2021
Background This is a review article on heparin-induced thrombocytopenia, an adverse effect of heparin therapy, and vaccine-induced immune thrombotic thrombocytopenia, occurring in some patients administered certain coronavirus vaccines.
Payel Datta, Fuming Zhang, Jonathan S. Dordick, Robert J. Linhardt   +3 more
doaj   +1 more source

Influence of different levels of heparin and antithrombin Ⅲ on human coagulation factor Ⅸ activity

Zhongguo shuxue zazhi, 2022
Objective To study the effect of different concentrations of heparin, ATⅢ or a mixture of heparin and antithrombin Ⅲ (ATⅢ) (1∶1)on the activity of human coagulation factor Ⅸ (FⅨ).
Changyong JIAN, Miaomiao DOU, chen CHEN, An ZHOU, Chao GAO, Cuiping ZHANG   +5 more
doaj   +1 more source

Quantitative Analysis of Impurities in Unfractionated Heparin of Bovine Origin

Frontiers in Medicine, 2020
The USP heparin sodium monograph lists impurities with specifications developed for porcine derived products. Most of these impurities are of biological origin and are present in porcine intestinal mucosa, the tissue source used in the production of ...
Wesley E. Workman, Kevin L. Carrick
doaj   +1 more source

Heparin-induced thrombocytopenia occurring early after living donor liver transplantation: a case report

Emergency and Critical Care Medicine, 2023
. Background. Thrombocytopenia commonly occurs early after liver transplantation. Heparin, usually administered as anticoagulant therapy for thrombosis, a common complication after liver transplantation, may cause heparin-induced thrombocytopenia ...
Naoya Iwasaki, Motohiro Sekino, Takanobu Hara, Akihiko Soyama, Masaaki Hidaka, Yusuke Kasai, Miki Suzumura, Hiroshi Araki, Rintaro Yano, Sojiro Matsumoto, Taiga Ichinomiya, Ushio Higashijima, Susumu Eguchi, Tetsuya Hara   +13 more
doaj   +1 more source

Poly-ion complex (PIC) formation of heparin and polyamines: PIC with tetrakis (3-aminopropyl) ammonium allows sustained release of heparin

Heliyon, 2020
Physical mixtures of cationic polymers and heparin have been developed to overcome the limitations of unfractionated heparin. In this study, we found that heparin associates with natural polyamines in water, resulting in the generation of a poly-ion ...
Daichi Ito, Dan Ge, Noriyuki Kogure, Hitomi Manaka, Yusuke Terui, Hiromitsu Takayama, Robert J. Linhardt, Toshihiko Toida, Kyohei Higashi   +8 more
doaj   +1 more source

Heparin modification of a biomimetic bone matrix modulates osteogenic and angiogenic cell response in vitro [PDF]

European Cells & Materials, 2017
In this study, the effect of heparin-modified collagen type I/hydroxyapatite (HA) nanocomposites on key processes of bone regeneration – osteogenesis and angiogenesis – was characterised in vitro.
M Quade, S Knaack, D Weber, U König, B Paul, P Simon, A Rösen-Wolff, R Schwartz-Albiez, M Gelinsky, A Lode   +9 more
doaj   +1 more source

Blended Heparin: A new Perspective to Guarantee the Supply of a Life-Saving Drug?

Clinical and Applied Thrombosis/Hemostasis, 2023
The risk of heparin shortage opens up the possibility of diversifying the sources of heparin by introducing products of other animal/organ origins. In addition to bovine heparin, already used in the past in the United States and Europe, ovine heparin can
Marco Guerrini MS
doaj   +1 more source

Serologic characterization of anti-protamine/heparin and anti-PF4/heparin antibodies

Blood Advances, 2017
: Anti-protamine (PRT)/heparin antibodies are a newly described class of heparin-dependent antibodies occurring in patients exposed to PRT and heparin during cardiac surgery.
Grace M. Lee, Manali Joglekar, Maragatha Kuchibhatla, Sanjay Khandelwal, Rui Qi, Lubica Rauova, Gowthami M. Arepally   +6 more
doaj   +1 more source

Heparin-induced thrombocytopenia: a rare presentation with skin necrosis

Dermatology Reports, 2023
Heparin-induced thrombocytopenia is the most clinically relevant non-haemorrhagic complication of heparin and is characterised by the presence of anti-PF4/heparin-IgG antibodies.
Filipa David, Ana Catarina Trigo, José Ribeiro, Joana Cancela   +3 more
doaj   +1 more source