Results 1 to 10 of about 460,061 (365)

Proteomic Identification and Functional Analysis of Babesia microti Reveals Heparin-Binding Proteins [PDF]

Journal of Tropical Medicine
Glycosaminoglycan (GAG) molecules on the surface of red blood cells play an important regulatory role in the invasion of merozoites of apicomplexan protozoa.
Yu Chun Cai, Bin Xu, Yan Hong Chu, Ying Fang Yu, Jia Hui Sun, Zi Ran Mo, Han Yin Yang, Shu Ning Yan, Mu Xin Chen, Jia Xu Chen   +9 more
doaj   +2 more sources

The chemistry of heparin [PDF]

Biochemical Journal, 1935
Erik Jorpes
openalex   +4 more sources

Effectiveness of therapeutic heparin versus prophylactic heparin on death, mechanical ventilation, or intensive care unit admission in moderately ill patients with covid-19 admitted to hospital: RAPID randomised clinical trial

British medical journal, 2021
Objective To evaluate the effects of therapeutic heparin compared with prophylactic heparin among moderately ill patients with covid-19 admitted to hospital wards. Design Randomised controlled, adaptive, open label clinical trial. Setting 28 hospitals in
M. Sholzberg, Grace H Tang, Hassan Rahhal, M. AlHamzah, L. B. Kreuziger, F. Áinle, F. Alomran, Khalid Alayed, M. Alsheef, Fahad AlSumait, C. E. Pompilio, C. Sperlich, S. Tangri, Terence Tang, Peter Jaksa, D. Suryanarayan, M. Almarshoodi, L. Castellucci, P. James, D. Lillicrap, M. Carrier, A. Beckett, C. Colovos, J. Jayakar, M. Arsenault, Cynthia Wu, K. Doyon, E. Andreou, Vera Dounaevskaia, E. Tseng, Gloria Lim, M. Fralick, S. Middeldorp, Agnes Y. Y. Lee, F. Zuo, B. D. da Costa, K. Thorpe, E. Negri, M. Cushman, P. Jüni, A. Laupacis, Yulia Lin, Andrew G. Day, B. Rochwerg, J. Abdulrehman, M. Gergi, R. Kondo, B. Piloto, Guilherme de Abreu Pereira, F. Valente, Ariel Fernando Villarroel Agreda, Pablo Andres Munoz Torres, Maíra Oliveira Moraes, Claudia de Lucena Moreira, Fernando Galassi Stocco Neto, Fabíola Vieira Duarte Baptista, J. A. Moreira, Augusto Séttemo Ferreira, Paula Frudit, G. Martínez, H. P. Souza, R. A. B. Neto, E. D’Amico, E. Padrão, Fernando Sarin da Mota e Albuquerque, G. Zangrossi, A. K. Kanasiro, Alissom Vitti Cincoto, Hugo de Souza Reis, Vitor Miyashiro Arias da Silva, A. Bellintani, Vivian dos Santos Pereira, Yohan Washington de Oliveira, B. J. Carvalho, Mariana de Souza Novaes, Henrique Brito Silveira, Gabriel César Alves de Avelar, Lara Bonanni Mota, Karina Caciola, Matheus de Arêa Leão Freire Marim, Tales Cabral Monsalvarga, Alexandre Salgado Blanco Santos, A. Haydar, Gabriella Seixas Sampaio Saraiva, Sabrina Correa da Costa Ribeiro, Julio Flavio Meirelles Marchini, Julio Cesar Garcia de Alencar, Ana Catharina de Seixas Santos, Caroline Millette, M. Lebeau, Céline Devaux, M. Boutin, T. N. Nguyen, L. Srour, Flávia De Angelis, Mariane Fugulin, A. Binnie, S. A. Bejaimal, A. Binding, Rosa M. Marticorena, G. Ginocchio, E. Kaplovitch, K. Rymaszewski, A. Raissi, Marcelo A. Falappa, Blair Ernst, A. Ali, M. Romano, Mobina Khurram, Christie Kim, A. Kapur, Michelle L. Edwards, Vidushi Swarup, B. Camilotti, J. Jani, Jeff Carter, Mark R. Gillrie, Davinder Sidhu, Traci Robinson, Krystina Stutely, I. Watpool, R. Porteous, K. Jao, Jean-Samuel Boudreault-Pedneault, Christopher E. Kandel, Maureen Taylor, Wei En Enoch Choo, Laura Parsons, Ann Dowbenka, Gitana Ramonas, S. Nikitin, Jeffery M. Patterson, M. Hnatiuk, Anca Tapardel, S. T. Lapner, T. Carpenter, Lori Rackel, Rebecca M. Cairns, Jessica Pinder, P. Anglin, Catherine McPherson, Liselle Chiverton, David Barbosa, Shany Loukiantchenko, Y. Shamiss, D. Tassy, S. Shivakumar, Mary M. Keating, Susan Pleasance, B. Kevane, S. Cullivan, N. Power, P. Doran, K. Leamy, Aoife C Kelly, Conor Moran, Mairead O’Connor, Aoife McDonnell, Roseanne Boyce, Faiza Sefroun, R. Hussain, P. Murray, A. Malara, B. Molloy, Meadbh O’Halloran, Emer Cunningham, J. Lambert, A. Cotter, B. Marsh, G. Sheehan, E. Muldoon, J. Woo, S. Gaine, Deirdre Morley, F. AlGahtani, I. Almaghlouth, Sondus I. Ata, Fai Alkhathlan, N. Khalil, Israa Mohamed Hussein, Mohammed Bashir, Ahmed S. Bahammam, A. Alsultan, H. Alkofide, Tariq M. Alhawassi, Abdulhadi M Alqahtani, E. Zayed, A. Alsughayir, Yacoub Abuzied, Hazzaa AlZahrani, Jawaher M Al-Otaibi, Haya S Alothaimeen, Noura Alzannan, Amer Al Homssi, H. Abid, S. Jones, S. Broaddrick, N. Jain, R. King, M. Jindal, Kristen M. Sanfilippo, Patty Nieters, Muhammad Hammad, Aleeswa Francis Benny, Tariq A. Hamdan, Suhaib Kamal Ahmed Elobaid, Ibrahim Khafagi, S. S. Ahmed, AbduleRehman AlEssaie, Shamma AlAlawi, Khloud Bashir, Aysha Abdulla Salem Al Suwaidi, H. I. Ahmed, Mohamed Milad Ismail, El Mutasim Ahmed El Faki, Mercy Charles, Alice Dang, Gurpreet Lakhanpal, Dominic Lee, Prachi Ray, M. Naydenova, K. Wysocki, Aziz Jiwajee, Greg Wendling, Rebekah H. Boyle, E. Cornell, D. K. Mukaz   +226 more
semanticscholar   +1 more source

Platelet factor 4 polyanion immune complexes: heparin induced thrombocytopenia and vaccine-induced immune thrombotic thrombocytopenia

Thrombosis Journal, 2021
Background This is a review article on heparin-induced thrombocytopenia, an adverse effect of heparin therapy, and vaccine-induced immune thrombotic thrombocytopenia, occurring in some patients administered certain coronavirus vaccines.
Payel Datta, Fuming Zhang, Jonathan S. Dordick, Robert J. Linhardt   +3 more
doaj   +1 more source

Influence of different levels of heparin and antithrombin Ⅲ on human coagulation factor Ⅸ activity

Zhongguo shuxue zazhi, 2022
Objective To study the effect of different concentrations of heparin, ATⅢ or a mixture of heparin and antithrombin Ⅲ (ATⅢ) (1∶1)on the activity of human coagulation factor Ⅸ (FⅨ).
Changyong JIAN, Miaomiao DOU, chen CHEN, An ZHOU, Chao GAO, Cuiping ZHANG   +5 more
doaj   +1 more source

The versatile heparin in COVID‐19

Journal of Thrombosis and Haemostasis, 2020
Coagulopathy in corona virus infection has been shown to be associated with high mortality with high D-dimers being a particularly important marker for the coagulopathy.1 In the latest paper from the same group, the use of anticoagulant therapy with ...
J. Thachil
semanticscholar   +1 more source

Quantitative Analysis of Impurities in Unfractionated Heparin of Bovine Origin

Frontiers in Medicine, 2020
The USP heparin sodium monograph lists impurities with specifications developed for porcine derived products. Most of these impurities are of biological origin and are present in porcine intestinal mucosa, the tissue source used in the production of ...
Wesley E. Workman, Kevin L. Carrick
doaj   +1 more source

The 2019 coronavirus (SARS-CoV-2) surface protein (Spike) S1 Receptor Binding Domain undergoes conformational change upon heparin binding

bioRxiv, 2020
Many pathogens take advantage of the dependence of the host on the interaction of hundreds of extracellular proteins with the glycosaminoglycans heparan sulphate to regulate homeostasis and use heparan sulphate as a means to adhere and gain access to ...
Courtney J. Mycroft-West, Dunhao Su, S. Elli, Yong Li, S. Guimond, G. Miller, J. Turnbull, E. Yates, M. Guerrini, D. Fernig, M. Lima, M. Skidmore   +11 more
semanticscholar   +1 more source

Heparin Inhibits Cellular Invasion by SARS-CoV-2: Structural Dependence of the Interaction of the Spike S1 Receptor-Binding Domain with Heparin

Thrombosis and Haemostasis, 2020
The dependence of development and homeostasis in animals on the interaction of hundreds of extracellular regulatory proteins with the peri- and extracellular glycosaminoglycan heparan sulfate (HS) is exploited by many microbial pathogens as a means of ...
Courtney J. Mycroft-West, Dunhao Su, I. Pagani, T. Rudd, S. Elli, Neha S. Gandhi, S. Guimond, G. Miller, Maria C. Z. Meneghetti, H. Nader, Yong Li, Q. Nunes, P. Procter, N. Mancini, M. Clementi, A. Bisio, N. Forsyth, V. Ferro, J. Turnbull, M. Guerrini, D. Fernig, E. Vicenzi, E. Yates, M. Lima, M. Skidmore   +24 more
semanticscholar   +1 more source

Heparin as a therapy for COVID-19: current evidence and future possibilities

American Journal of Physiology - Lung cellular and Molecular Physiology, 2020
Coronavirus disease 2019 (COVID-19), the clinical syndrome associated with infection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has impacted nearly every country in the world.
J. Hippensteel, W. LaRivière, James F. Colbert, Christophe J. Langouët-Astrié, E. Schmidt   +4 more
semanticscholar   +1 more source